The DOI matches its Crossref record.
Notch1 is required for the coordinate segmentation of somites
Abstract
Members of the Notch family of transmembrane receptors mediate a number of developmental decisions in invertebrates. In order to study Notch function in a vertebrate organism, we have mutated the Notch1 gene of the mouse. Notch1 gene function is required for embryonic survival in the second half of gestation. In the first half of gestation, we have found no effect of the mutation on the normal programs of neurogenesis, myogenesis or apoptosis. We conclude that Notch1 function is not essential for these processes, at least in early postimplantation development. However, we have found that somitogenesis is delayed and disorganized in Notch1 mutant embryos. We propose that Notch1 normally coordinates the process of somitogenesis, and we provide a model of how this might occur.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Notch signaling: control of cell communication and cell fate
Lai, E. C. (2004) · Development · doi:10.1242/dev.01074 · Cited by 1,050
Skeletal and CNS Defects in Presenilin-1-Deficient Mice
Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J., & Tonegawa, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80244-5 · Cited by 959
Lawson, N. D., Scheer, N., Pham, V. N., Kim, C.-H., Chitnis, A. B., Campos-Ortega, J. A., & Weinstein, B. M. (2001) · Development · doi:10.1242/dev.128.19.3675 · Cited by 915
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F., & Kageyama, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2196 · Cited by 852
Conservation of the Notch signalling pathway in mammalian neurogenesis
Luis de la Pompa, J., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., et al. (1997) · Development · doi:10.1242/dev.124.6.1139 · Cited by 624
Self-citation
Metadata
- Authors
- Conlon, R. A., Reaume, A. G., & Rossant, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-05-01
- Volume
- 121
- Issue
- 5
- Pages
- 1533-1545
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2100699398
- Cited by
- 852
- References
- 0
- FWCI
- 14.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Notch1 is required for the coordinate segmentation of somites. https://app.cochat.ai/papers/10.1242/dev.121.5.1533
- The paper
- Conlon, R. A., Reaume, A. G., & Rossant, J. (1995). Notch1 is required for the coordinate segmentation of somites. Development. https://doi.org/10.1242/dev.121.5.1533
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
