The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mediator function of the human Rad51B–Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange
Open accessAbstract
Five Rad51-like proteins, referred to as Rad51 paralogs, have been described in vertebrates. We show that two of them, Rad51B and Rad51C, are associated in a stable complex. Rad51B–Rad51C complex has ssDNA binding and ssDNA-stimulated ATPase activities. We also examined the functional interaction of Rad51B–Rad51C with Rad51 and RPA. Even though RPA enhances Rad51-catalyzed DNA joint formation via removal of secondary structure in the ssDNA substrate, it can also compete with Rad51 for binding to the substrate, leading to suppressed reaction efficiency. The competition by RPA for substrate binding can be partially alleviated by Rad51B–Rad51C. This recombination mediator function of Rad51B–Rad51C is likely required for the assembly of the Rad51-ssDNA nucleoprotein filament in vivo.
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Citations
Cites
Brca1 Controls Homology-Directed DNA Repair
Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245
Sung, P. (1997) · Genes & Development · doi:10.1101/gad.11.9.1111 · Cited by 540
Self-citationRecombination factors of Saccharomyces cerevisiae
Sung, P., Trujillo, K. M., & Van Komen, S. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(00)00054-3 · Cited by 180
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Cited by
Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Sørensen, C. S., Hansen, L. T., Dziegielewski, J., Syljuåsen, R. G., Lundin, C., Bartek, J., & Helleday, T. (2005) · Nature Cell Biology · doi:10.1038/ncb1212 · Cited by 666
DNA double-strand break repair: From mechanistic understanding to cancer treatment
HELLEDAY, T., LO, J., VANGENT, D., & ENGELWARD, B. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.006 · Cited by 640
Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357
The RAD51 gene family, genetic instability and cancer
Thacker, J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.08.018 · Cited by 342
Metadata
- Authors
- Sigurdsson, S., Van Komen, S., Bussen, W., Schild, D., Albala, J. S., & Sung, P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-12-15
- Volume
- 15
- Issue
- 24
- Pages
- 3308-3318
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2152444838
- Cited by
- 261
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Sigurdsson, S., Van Komen, S., Bussen, W., Schild, D., Albala, J. S., & Sung, P. (2001). Mediator function of the human Rad51B–Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange. Genes & Development. https://doi.org/10.1101/gad.935501
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