Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339 · see citing works

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210 · see citing works

Integrated genomic analyses of ovarian carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927 · see citing works

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683 · see citing works

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069 · see citing works

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198 · see citing works

Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies

Antoniou, A., Pharoah, P. D. P., Narod, S., Risch, H. A., Eyfjord, J. E., Hopper, J. L., Loman, N., Olsson, H., Johannsson, O., Borg, Å., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/375033 · Cited by 3,680 · see citing works

Identification of the breast cancer susceptibility gene BRCA2

Wooster, R., Bignell, G. R., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S. G., Gumbs, C. E., Micklem, G., et al. (1995) · Nature · doi:10.1038/378789a0 · Cited by 3,645 · see citing works

Breast and Ovarian Cancer Risks Due to Inherited Mutations in <i>BRCA1</i> and <i>BRCA2</i>

King, M.-C., Marks, J. H., & Mandell, J. B. (2003) · Science · doi:10.1126/science.1088759 · Cited by 2,229 · see citing works

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671 · see citing works

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,622 · see citing works

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459 · see citing works

Cancer risks in BRCA2 mutation carriers.

Olsson, H. (1999) · Journal of the National Cancer Institute · doi:10.1093/jnci/91.15.1310 · Cited by 1,404 · see citing works

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384 · see citing works

BRCA1 mutations in primary breast and ovarian carcinomas.

Futreal, P., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L., Haugen-Strano, A., Swensen, J., & Miki, Y. (1994) · Science · doi:10.1126/science.7939630 · Cited by 1,378 · see citing works

Human CtIP promotes DNA end resection

Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362 · see citing works

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

McCabe, N., Turner, N. C., Lord, C. J., Kluzek, K., Białkowska, A., Swift, S., Giavara, S., O’Connor, M. J., Tutt, A. N. J., Zdzienicka, M. Z., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0140 · Cited by 1,311 · see citing works

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., & Jasin, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.041 · Cited by 1,258 · see citing works

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245 · see citing works

Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

Rothkamm, K., Krüger, I., Thompson, L. H., & Lübrich, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5706-5715.2003 · Cited by 1,187 · see citing works

Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia

Howlett, N. G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., de Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. (2002) · Science · doi:10.1126/science.1073834 · Cited by 1,149 · see citing works

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,071 · see citing works

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

Jonkers, J., Meuwissen, R. L. J., van der Gulden, H. M. L., Peterse, H. L., van der Valk, M., & Berns, A. J. M. (2001) · Nature Genetics · doi:10.1038/ng747 · Cited by 1,053 · see citing works

Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas

Pennington, K. P., Walsh, T., Harrell, M. I., Lee, M. K., Pennil, C. C., Rendi, M. H., Thornton, A., Norquist, B. M., Casadei, S., Nord, A. S., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2287 · Cited by 1,050 · see citing works

The importance of repairing stalled replication forks

Cox, M. M., Goodman, M. F., Kreuzer, K. N., Sherratt, D. J., Sandler, S. J., & Marians, K. J. (2000) · Nature · doi:10.1038/35003501 · Cited by 1,044 · see citing works

RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

Huen, M. S. Y., Grant, R. A., Manke, I. A., Minn, K. T., Yu, X., Yaffe, M. B., & Chen, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.041 · Cited by 1,027 · see citing works

Resistance to therapy caused by intragenic deletion in BRCA2

Edwards, S. L., Brough, R., Lord, C. J., Natrajan, R., Vatcheva, R., Levine, D. A., Boyd, J., Reis-Filho, J. S., & Ashworth, A. (2008) · Nature · doi:10.1038/nature06548 · Cited by 1,011 · see citing works

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

Moynahan, M. E., Pierce, A. J., & Jasin, M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00174-5 · Cited by 1,007 · see citing works

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

Rahman, N., Seal, S., Thompson, D. J., Kelly, P. F., Renwick, A., Elliott, A., Reid, S., Spanova, K., Barfoot, R., Chagtai, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1959 · Cited by 1,002 · see citing works

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Bouwman, P., Aly, A., Escandell, J. M., Pieterse, M., Bartkova, J., van der Gulden, H., Hiddingh, S., Thanasoula, M., Kulkarni, A., Yang, Q., et al. (2010) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.1831 · Cited by 1,001 · see citing works

Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

Foulkes, W. D. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg050 · Cited by 970 · see citing works

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

Doil, C., Mailand, N., Bekker‐Jensen, S., Ménard, P., Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bártek, J., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.041 · Cited by 938 · see citing works

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2

Schlacher, K., Wu, H., & Jasin, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.015 · Cited by 936 · see citing works

Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing

Walsh, T., Casadei, S., Lee, M. K., Pennil, C. C., Nord, A. S., Thornton, A., Roeb, W., Agnew, K. J., Stray, S. M., Wickramanayake, A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115052108 · Cited by 929 · see citing works

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 923 · see citing works

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

Escribano‐Diaz, C., Orthwein, A., Fradet‐Turcotte, A., Xing, M., Young, J. T. F., Tkáč, J., Cook, M. A., Rosebrock, A. P., Munro, M., Canny, M. D., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.001 · Cited by 903 · see citing works

Repair of Strand Breaks by Homologous RecombinationPreprint

Jasin, M., & Rothstein, R. J. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012740 · Cited by 877 · see citing works

The BRCT Domain Is a Phospho-Protein Binding Domain

Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862 · see citing works

Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2

Xia, B., Sheng, Q., Nakanishi, K., Ohashi, A., Wu, J., Christ, N., Liu, X., Jasin, M., Couch, F. J., & Livingston, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.022 · Cited by 861 · see citing works

Breast-Cancer Risk in Families with Mutations in PALB2

Antoniou, A. C., Casadei, S., Heikkinen, T., Barrowdale, D., Pylkäs, K., Roberts, J., Lee, A., Subramanian, D., Leeneer, K. D., Fostira, F., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1400382 · Cited by 853 · see citing works

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

Tavtigian, S. V., Simard, J., Rommens, J. M., Couch, F. J., Shattuck-Eidens, D. M., Neuhausen, S. L., Merajver, S. D., Thorlacius, S., Offit, K., Stoppa‐Lyonnet, D., et al. (1996) · Nature Genetics · doi:10.1038/ng0396-333 · Cited by 838 · see citing works

Exomic Sequencing Identifies <i>PALB2</i> as a Pancreatic Cancer Susceptibility Gene

Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826 · cited 1× · see citing works

Re: Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

van der Groep, P., Bouter, A., van der Zanden, R. A., Menko, F. H., Buerger, H., Verheijen, R. H. M., van der Wall, E., & van Diest, P. J. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh114 · Cited by 798 · see citing works

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

Tsuzuki, T., Fujii, Y., Sakumi, K., Tominaga, Y., Nakao, K., Sekiguchi, M., Matsushiro, A., Yoshimura, Y., & MoritaT (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6236 · Cited by 792 · see citing works

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

The Breast Cancer Susceptibility Collaboration (UK), Seal, S., Thompson, D., Renwick, A., Elliott, A., Kelly, P., Barfoot, R., Chagtai, T., Jayatilake, H., Ahmed, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1902 · Cited by 746 · see citing works

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M.-C. W., Hwang, L.-Y., Bowcock, A. M., & Baer, R. J. (1996) · Nature Genetics · doi:10.1038/ng1296-430 · Cited by 743 · see citing works

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

Meindl, A., Hellebrand, H., Wiek, C., Erven, V., Wappenschmidt, B., Niederacher, D., Freund, M., Lichtner, P., Hartmann, L., Schaal, H., et al. (2010) · Nature Genetics · doi:10.1038/ng.569 · Cited by 743 · see citing works

Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease.

Rouet, P., Smih, F., & Jasin, M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8096 · Cited by 739 · see citing works

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA RepairPreprint

Mehta, A., & Haber, J. E. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016428 · Cited by 728 · see citing works

Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

Davies, A. A., Masson, J., McIlwraith, M. J., Stasiak, A. Z., Stasiak, A., Venkitaraman, A. R., & West, S. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00175-7 · Cited by 720 · see citing works

Purified human BRCA2 stimulates RAD51-mediated recombination

Jensen, R. B., Carreira, A., & Kowalczykowski, S. C. (2010) · Nature · doi:10.1038/nature09399 · Cited by 715 · see citing works

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure

Yang, H., Jeffrey, P. D., Miller, J. J., Kinnucan, E., Sun, Y., Thomä, N. H., Zheng, N., Chen, P., Lee, W., & Pavletich, N. P. (2002) · Science · doi:10.1126/science.297.5588.1837 · Cited by 705 · see citing works

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature · doi:10.1038/nature01230 · Cited by 704 · see citing works

Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

Wang, B., Matsuoka, S., Ballif, B. A., Zhang, D., Smogorzewska, A., Gygi, S. P., & Elledge, S. J. (2007) · Science · doi:10.1126/science.1139476 · Cited by 695 · see citing works

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

Lim, D., & Hasty, P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.7133 · Cited by 687 · see citing works

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674 · see citing works

RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

Sobhian, B., Shao, G., Lilli, D. R., Culhane, A. C., Moreau, L. A., Xia, B., Livingston, D. M., & Greenberg, R. A. (2007) · Science · doi:10.1126/science.1139516 · Cited by 672 · see citing works

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

Liang, F., Han, M., Romanienko, P. J., & Jasin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5172 · Cited by 649 · see citing works

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

Reid, S., Schindler, D., Hanenberg, H., Barker, K., Hanks, S., Kalb, R., Neveling, K., Kelly, P., Seal, S., Freund, M., et al. (2007) · Nature Genetics · doi:10.1038/ng1947 · Cited by 642 · see citing works

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G. E., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80276-2 · Cited by 635 · see citing works

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626 · see citing works

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

Chapman, J. R., Barral, P., Vannier, J., Borel, V., Steger, M., Tomás‐Loba, A., Sartori, A. A., Adams, I. R., Batista, F. D., & Boulton, S. J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.002 · Cited by 624 · see citing works

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

Gao, Y., Ferguson, D., Xie, W., Manis, J., Sekiguchi, J., Frank, K., Chaudhuri, J., Horner, J., DePinho, R., & Alt, F. (2000) · Nature · doi:10.1038/35009138 · Cited by 608 · see citing works

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Sy, S. M.-H., Huen, M. S. Y., & Chen, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811159106 · Cited by 607 · see citing works

53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection

Zimmermann, M., Lottersberger, F., Buonomo, S. B. C., Sfeir, A. J., & de Lange, T. (2013) · Science · doi:10.1126/science.1231573 · Cited by 594 · see citing works

Sister chromatid gene conversion is a prominent double‐strand break repair pathway in mammalian cells

Johnson, R. D., & Jasin, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3398 · Cited by 590 · see citing works

How the Fanconi Anemia Pathway Guards the Genome

Moldovan, G., & D’Andrea, A. D. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134222 · Cited by 586 · see citing works

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B., & Yu, X. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.018 · Cited by 556 · see citing works

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, M. H., & Hiom, K. (2009) · Nature · doi:10.1038/nature07955 · Cited by 556 · see citing works

Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

Kim, H., Chen, J., & Yu, X. (2007) · Science · doi:10.1126/science.1139621 · Cited by 540 · see citing works

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

Wong, A. K. C., Pero, R. S., Ormonde, P. A., Tavtigian, S. V., & Bartel, P. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.31941 · Cited by 539 · see citing works

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.Preprint

Ludwig, T. E., Chapman, D. L., Papaioannou, V. E., & Efstratiadis, A. (1997) · Genes & Development · doi:10.1101/gad.11.10.1226 · Cited by 539 · see citing works

XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

Liu, N., Lamerdin, J. E., Tebbs, R. S., Schild, D., Tucker, J. D., Shen, M. R., Brookman, K. W., Siciliano, M. J., Walter, C. A., Fan, W., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80078-7 · Cited by 534 · see citing works

Germline mutations in RAD51D confer susceptibility to ovarian cancer

Loveday, C., Turnbull, C., Ramsay, E., Hughes, D., Ruark, E., Frankum, J. R., Bowden, G. R., Kalmyrzaev, B., Warren-Perry, M., Snape, K. M. G., et al. (2011) · Nature Genetics · doi:10.1038/ng.893 · Cited by 530 · see citing works

Chromosome Instability and Defective Recombinational Repair in Knockout Mutants of the Five Rad51 Paralogs

Takata, M., Sasaki, M. S., Tachiiri, S., Fukushima, T., Sonoda, E., Schild, D., Thompson, L. H., & Takeda, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2858-2866.2001 · Cited by 523 · see citing works

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

Tang, J., Cho, N. W., Cui, G., Manion, E. M., Shanbhag, N. M., Botuyan, M. V., Mer, G., & Greenberg, R. A. (2013) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.2499 · Cited by 521 · see citing works

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cellsPreprint

Pierce, A. J., Hu, P., Han, M., Ellis, N. A., & Jasin, M. (2001) · Genes & Development · doi:10.1101/gad.946401 · Cited by 514 · see citing works

Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences

Stark, J. M., Pierce, A. J., Oh, J., Pastink, A., & Jasin, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9305-9316.2004 · Cited by 501 · see citing works

BRCA1 and its toolbox for the maintenance of genome integrity

Huen, M. S. Y., Sy, S. M.-H., & Chen, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2831 · Cited by 495 · see citing works

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

Brzović, P. S., Rajagopal, P., Hoyt, D. W., King, M., & Klevit, R. E. (2001) · Nature Structural Biology · doi:10.1038/nsb1001-833 · Cited by 494 · see citing works

DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

Frank, K. M., Sharpless, N. E., Gao, Y., Sekiguchi, J., Ferguson, D. O., Zhu, C., Manis, J. P., Horner, J. W., DePinho, R. A., & Alt, F. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80264-6 · Cited by 492 · see citing works

DNA Damage ResponsePreprint

Giglia‐Mari, G., Zotter, A., & Vermeulen, W. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000745 · Cited by 487 · see citing works

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

Zhu, Q., Pao, G. M., Huynh, A. M., Suh, H., Tonnu, N. U., Nederlof, P. M., Gage, F. H., & Verma, I. M. (2011) · Nature · doi:10.1038/nature10371 · Cited by 486 · see citing works

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

Esashi, F., Christ, N., Gannon, J., Liu, Y., Hunt, T., Jasin, M., & West, S. C. (2005) · Nature · doi:10.1038/nature03404 · Cited by 473 · see citing works

A recurrent mutation in PALB2 in Finnish cancer families

Erkko, H., Xia, B., Nikkilä, J., Schleutker, J., Syrjäkoski, K., Mannermaa, A., Kallioniemi, A. H., Pylkäs, K., Karppinen, S., Rapakko, K., et al. (2007) · Nature · doi:10.1038/nature05609 · Cited by 466 · see citing works

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2

Xia, B., Dorsman, J. C., Ameziane, N., de Vries, Y., Rooimans, M. A., Sheng, Q., Pals, G., Errami, A., Gluckman, E., Llera, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1942 · Cited by 465 · see citing works

Mechanism and Regulation of Meiotic Recombination InitiationPreprint

Lam, I., & Keeney, S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016634 · Cited by 457 · see citing works

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

Wang, B., & Elledge, S. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710061104 · Cited by 446 · see citing works

Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination

Essers, J., Hendriks, R. W., Swagemakers, S. M. A., Troelstra, C., de Wit, J., Bootsma, D., Hoeijmakers, J. H. J., & Kanaar, R. (1997) · Cell · doi:10.1016/s0092-8674(00)80199-3 · Cited by 435 · see citing works

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

Connor, F., Bertwistle, D., Mee, P. J., Ross, G. M., Swift, S., Grigorieva, E. F., Tybulewicz, V. L. J., & Ashworth, A. (1997) · Nature Genetics · doi:10.1038/ng1297-423 · Cited by 432 · see citing works

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

Levitus, M., Waisfisz, Q., Godthelp, B. C., Vries, Y. D., Hussain, S., Wiegant, W. W., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, M. A., Pals, G., et al. (2005) · Nature Genetics · doi:10.1038/ng1625 · Cited by 432 · see citing works

Mutation in Brca2 stimulates error‐prone homology‐directed repair of DNA double‐strand breaks occurring between repeated sequences

Tutt, A. N. J., Bertwistle, D., Valentine, J., Gabriel, A., Swift, S., Ross, G., Griffin, C. S., Thacker, J., & Ashworth, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4704 · Cited by 429 · see citing works

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

Wu, Y., Shin-ya, K., & Brosh, R. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02210-07 · Cited by 428 · see citing works

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

Chen, L., Nievera, C. J., Lee, A. Y., & Wu, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710245200 · Cited by 425 · see citing works

Cancer risks in BRCA2 families: estimates for sites other than breast and ovary

van Asperen, C. J., Brohet, R. M., Meijers-Heijboer, E. J., Hoogerbrugge, N., Verhoef, S., Vasen, H. F. A., Ausems, M. G. E. M., Menko, F. H., Gómez-García, E. B., Klijn, J. G. M., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.028829 · Cited by 419 · see citing works

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

Yu, X., & Chen, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9478-9486.2004 · Cited by 410 · see citing works

Mutation of the RAD51C gene in a Fanconi anemia–like disorder

Vaz, F., Hanenberg, H., Schuster, B., Barker, K., Wiek, C., Erven, V., Neveling, K., Endt, D., Kesterton, I., Autore, F., et al. (2010) · Nature Genetics · doi:10.1038/ng.570 · Cited by 408 · see citing works

Mutations in BRIP1 confer high risk of ovarian cancer

Rafnar, Þ., Gudbjartsson, D. F., Sulem, P., Jónasdóttir, Á., Sigurðsson, Á., Jónasdóttir, A., Besenbacher, S., Lundin, P., Stacey, S., Guðmundsson, J., et al. (2011) · Nature Genetics · doi:10.1038/ng.955 · Cited by 406 · see citing works

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

Liu, J., Doty, T., Gibson, B. A., & Heyer, W. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1904 · Cited by 396 · see citing works

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P. R., & Cantor, S. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.004 · Cited by 396 · see citing works

Identification and purification of two distinct complexes containing the five RAD51 paralogsPreprint

Masson, J., Tarsounas, M., Stasiak, A. Z., Stasiak, A., Punatar, R. S., McIlwraith, M. J., Benson, F. E., & West, S. C. (2001) · Genes & Development · doi:10.1101/gad.947001 · Cited by 395 · see citing works

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

Chen, P., Chen, C., Chen, Y., Xiao, J., Sharp, Z. D., & Lee, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5287 · Cited by 394 · see citing works

Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

Proia, T. A., Keller, P. J., Gupta, P. B., Klebba, I., Jones, A. D., Sedic, M., Gilmore, H. L., Tung, N., Naber, S. P., Schnitt, S. J., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.007 · Cited by 393 · see citing works

The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression

Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A., & Baer, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25388 · Cited by 389 · see citing works

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

Nakanishi, K., Yang, Y.-G., Pierce, A. J., Taniguchi, T., Digweed, M., D'Andrea, A. D., Wang, Z.-Q., & Jasin, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407796102 · Cited by 384 · see citing works

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

Moynahan, M. E., Cui, T. Y., & Jasin, M. (2001) · PubMed · Cited by 382 · see citing works

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

Levran, O., Attwooll, C., Henry, R. T., Milton, K. L., Neveling, K., Rio, P., Batish, S. D., Kalb, R., Velleuer, E., Barral, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1624 · Cited by 370 · see citing works

Two Percent of Men with Early-Onset Prostate Cancer Harbor Germline Mutations in the BRCA2 Gene

Edwards, S. M., Kote‐Jarai, Z., Meitz-Hopkins, J. C., Hamoudi, R., Hope, Q., Osin, P., Jackson, R., Southgate, C., Singh, R., Falconer, A., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/345310 · Cited by 365 · see citing works

Introduction of Double-Strand Breaks into the Genome of Mouse Cells by Expression of a Rare-Cutting Endonuclease

Rouet, P., Smih, F., & Jasin, M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8096-8106.1994 · Cited by 363 · see citing works

Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

Ruffner, H., Joazeiro, C. A. P., Hemmati, D., Hunter, T., & Verma, I. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081068398 · Cited by 359 · see citing works

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

Christensen, D. E., Brzovic, P. S., & Klevit, R. E. (2007) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb1295 · Cited by 351 · see citing works

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA–ssDNA junction

Yang, H., Li, Q., Fan, J., Holloman, W. K., & Pavletich, N. P. (2005) · Nature · doi:10.1038/nature03234 · Cited by 335 · see citing works

Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation

Rijkers, T., van den Ouweland, J., Morolli, B., Rolink, A. G., Baarends, W. M., Sloun, P. P. H. V., Lohman, P. H. M., & Pastink, A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6423 · Cited by 330 · see citing works

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

Chapman, J. R., Sossick, A. J., Boulton, S. J., & Jackson, S. P. (2012) · Journal of Cell Science · doi:10.1242/jcs.105353 · Cited by 327 · see citing works

Collaboration and competition between DNA double‐strand break repair pathways

Kass, E. M., & Jasin, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.057 · Cited by 326 · see citing works

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

Johnson, R. D., Liu, N., & Jasin, M. (1999) · Nature · doi:10.1038/43932 · Cited by 323 · see citing works

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

Tutt, A. N. J., Gabriel, A., Bertwistle, D., Connor, F., Paterson, H., Peacock, J., Ross, G., & Ashworth, A. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80479-5 · Cited by 321 · see citing works

Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2

Daniels, M. J., Wang, Y., Lee, M.-Y., et al. (2004) · Science · doi:10.1126/science.1102574 · Cited by 319 · see citing works

RAD51C Is Required for Holliday Junction Processing in Mammalian Cells

Liu, Y., Masson, J., Punatar, R. S., O’Regan, P., & West, S. C. (2004) · Science · doi:10.1126/science.1093037 · Cited by 310 · see citing works

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M. (2006) · Genes &amp; Development · doi:10.1101/gad.1381306 · Cited by 308 · see citing works

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

Buisson, R., Dion‐Côté, A., Coulombe, Y., Launay, H., Cai, H., Stasiak, A. Z., Stasiak, A., Xia, B., & Masson, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1915 · Cited by 303 · see citing works

PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2

Zhang, F., Fan, Q., Ren, K., & Andreassen, P. R. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0123 · Cited by 303 · see citing works

The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin

Wu-Baer, F., Lagrazon, K., Yuan, W., & Baer, R. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300249200 · Cited by 302 · see citing works

Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

Venkitaraman, A. R. (2014) · Science · doi:10.1126/science.1252230 · Cited by 290 · see citing works

Brca2 is required for embryonic cellular proliferation in the mouse.Preprint

Suzuki, A., de la Pompa, J. L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., Wakeham, A. C., Itié, A., et al. (1997) · Genes & Development · doi:10.1101/gad.11.10.1242 · Cited by 287 · see citing works

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIPPreprint

Yu, X., Fu, S., Lai, M., Baer, R. J., & Chen, J. (2006) · Genes & Development · doi:10.1101/gad.1431006 · Cited by 283 · see citing works

Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype

Sawyer, S. L., Tian, L., Kähkönen, M., Schwartzentruber, J., Kircher, M., Majewski, J., Dyment, D. A., Innes, A. M., Boycott, K. M., Moreau, L. A., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1156 · Cited by 282 · see citing works

End Resection at Double-Strand Breaks: Mechanism and RegulationPreprint

Symington, L. S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016436 · Cited by 281 · see citing works

Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2

Esashi, F., Galkin, V. E., Yu, X., Egelman, E. H., & West, S. C. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1245 · Cited by 277 · see citing works

Full‐length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

Shin, D. S., Pellegrini, L., Daniels, D. S., Yelent, B., Craig, L., Bates, D. L., Yu, D. S., Shivji, M. K. K., Hitomi, C., Arvai, A. S., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg429 · Cited by 270 · see citing works

The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51

Carreira, A., Hilario, J., Amitani, I., Baskin, R. J., Shivji, M. K. K., Venkitaraman, A. R., & Kowalczykowski, S. C. (2009) · Cell · doi:10.1016/j.cell.2009.02.019 · Cited by 268 · see citing works

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

Feng, L., Fong, K.-W., Wang, J., Wang, W., & Chen, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457440 · Cited by 267 · see citing works

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

Morris, J. R., & Solomon, E. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh095 · Cited by 267 · see citing works

Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions

der Zwet, M. K.-V., Overkamp, W. J., van Lange, R. E. E., Essers, J., van Duijn-Goedhart, A., Wiggers, I., Swaminathan, S., van Buul, P. V., Errami, A., Tan, R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.669-679.2002 · Cited by 267 · see citing works

Quantitation of DNA double-strand break resection intermediates in human cells

Zhou, Y., Caron, P., Legube, G., & Paull, T. T. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1309 · Cited by 266 · see citing works

Mechanisms of Gene Duplication and AmplificationPreprint

Reams, A. B., & Roth, J. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016592 · Cited by 266 · see citing works

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

Johnson, N., Johnson, S. F., Yao, W., Li, Y.-C., Choi, Y.-E., Bernhardy, A. J., Wang, Y., Capelletti, M., Sarosiek, K. A., Moreau, L. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305170110 · Cited by 264 · see citing works

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

Xia, F., Taghian, D. G., DeFrank, J. S., Zeng, Z., Willers, H., Iliakis, G. E., & Powell, S. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151253498 · Cited by 263 · see citing works

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

Thorslund, T., McIlwraith, M. J., Compton, S. A., Lekomtsev, S., Petronczki, M. P., Griffith, J. D., & West, S. C. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1905 · Cited by 262 · see citing works

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

Drost, R., Bouwman, P., Rottenberg, S., Boon, U., Schut, E., Klarenbeek, S., Klijn, C. N., van der Heijden, I., van der Gulden, H. M. L., Wientjens, E., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.11.014 · Cited by 261 · see citing works

Double-strand-break-induced homologous recombination in mammalian cells

Johnson, R. D., & Jasin, M. (2001) · Biochemical Society Transactions · doi:10.1042/0300-5127:0290196 · Cited by 261 · see citing works

Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.

Tebbs, R. S., Zhao, Y., Tucker, J. D., Scheerer, J. B., Siciliano, M., Hwang, M. S., Liu, N., Legerski, R. J., & Thompson, L. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.14.6354 · Cited by 257 · see citing works

Mediator function of the human Rad51B–Rad51C complex in Rad51/RPA-catalyzed DNA strand exchangePreprint

Sigurðsson, S., Komen, S. V., Bussen, W., Schild, D., Albala, J. S., & Sung, P. (2001) · Genes & Development · doi:10.1101/gad.935501 · Cited by 257 · see citing works

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility proteinPreprint

Lomonosov, M., Anand, S., Sangrithi, M. N., Davies, R. C., & Venkitaraman, A. R. (2003) · Genes & Development · doi:10.1101/gad.279003 · Cited by 256 · see citing works

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

Bunting, S. F., Callén, E., Kozak, M. L., Kim, J. M., Wong, N., López-Contreras, A. J., Ludwig, T., Baer, R., Faryabi, R. B., Malhowski, A., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.02.015 · Cited by 252 · see citing works

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

London, T. B. C., Barber, L. J., Mosedale, G., Kelly, G. P., Balasubramanian, S., Hickson, I. D., Boulton, S. J., & Hiom, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808152200 · Cited by 252 · see citing works

Germline RAD51C mutations confer susceptibility to ovarian cancer

Loveday, C., Turnbull, C., Ruark, E., Xicola, R. M., Ramsay, E., Hughes, D., Warren-Perry, M., Snape, K. M. G., Eccles, D., Evans, D. G., et al. (2012) · Nature Genetics · doi:10.1038/ng.2224 · Cited by 251 · see citing works

Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice

Deans, B., Griffin, C. S., Maconochie, M. K., & Thacker, J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6675 · Cited by 250 · see citing works

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo

Bishop, D. K., Ear, U., Bhattacharyya, A., Calderone, C., Beckett, M., Weichselbaum, R. R., & Shinohara, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21482 · Cited by 247 · see citing works

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

Shakya, R., Reid, L. J., Reczek, C. R., Cole, F., Egli, D., Lin, C.-S., deRooij, D. G., Hirsch, S., Ravi, K., Hicks, J. B., et al. (2011) · Science · doi:10.1126/science.1209909 · Cited by 244 · see citing works

Double-strand-break-induced homologous recombination in mammalian cells

Johnson, R. D., & Jasin, M. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290196 · Cited by 244 · see citing works

Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.

Collins, N., McManus, R., Wooster, R., Mangion, J., Seal, S., Lakhani, S. R., Ormiston, W. J., Daly, P. A., Ford, D., & Easton, D. F. (1995) · PubMed · Cited by 243 · see citing works

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

Cantor, S., Drapkin, R., Zhang, F., Lin, Y., Han, J., Pamidi, S., & Livingston, D. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308717101 · Cited by 240 · see citing works

Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase

Nishikawa, H., Ooka, S., Sato, K., Arima, Κ., Okamoto, J., Klevit, R. E., Fukuda, M., & Ohta, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308540200 · Cited by 238 · see citing works

Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair

Long, D. T., Räschle, M., Joukov, V., & Walter, J. C. (2011) · Science · doi:10.1126/science.1204258 · Cited by 238 · see citing works

RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein

Mizuta, R., LaSalle, J. M., Cheng, H.-L., Shinohara, A., Ogawa, H., Copeland, N. G., Jenkins, N. A., Lalande, M., & Alt, F. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6927 · Cited by 235 · see citing works

Coupled Homologous and Nonhomologous Repair of a Double-Strand Break Preserves Genomic Integrity in Mammalian Cells

Richardson, C. A., & Jasin, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.9068-9075.2000 · Cited by 233 · see citing works

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear fociPreprint

Hu, Y., Scully, R., Sobhian, B., Xie, A., Shestakova, E. A., & Livingston, D. M. (2011) · Genes & Development · doi:10.1101/gad.2011011 · Cited by 232 · see citing works

Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients

Özcelik, H., Schmocker, B., Nicola, N. D., Shi, X.-H., Langer, B., Moore, M. J., Taylor, B., Narod, S. A., Darlington, G., Andrulis, I. L., et al. (1997) · Nature Genetics · doi:10.1038/ng0597-17 · Cited by 225 · see citing works

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

Coleman, K. A., & Greenberg, R. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.213728 · Cited by 224 · see citing works

Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats

Davies, O. R., & Pellegrini, L. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1251 · Cited by 223 · see citing works

Proteasome Involvement in the Repair of DNA Double-Strand Breaks

Krogan, N. J., Lam, M. H. Y., Fillingham, J., Keogh, M., Gebbia, M., Li, J., Datta, N., Cagney, G., Buratowski, S., Emili, A., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.033 · Cited by 221 · see citing works

A Critical Role for the Ubiquitin-Conjugating Enzyme Ubc13 in Initiating Homologous Recombination

Zhao, G., Sonoda, E., Barber, L. J., Oka, H., Murakawa, Y., Yamada, K., Ikura, T., Wang, X., Kobayashi, M., Yamamoto, K., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.029 · Cited by 218 · see citing works

Telomere Maintenance Requires the RAD51D Recombination/Repair Protein

Tarsounas, M., Muñoz, P., Claas, A., Smiraldo, P. G., Pittman, D. L., Blasco, M. A., & West, S. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00337-x · Cited by 216 · see citing works

The Dissolution of Double Holliday JunctionsPreprint

Bizard, A. H., & Hickson, I. D. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016477 · Cited by 216 · see citing works

Holliday Junction ResolvasesPreprint

Wyatt, H. D. M., & West, S. C. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a023192 · Cited by 213 · see citing works

Analysis of PALB2 / FANCN -associated breast cancer families

Tischkowitz, M. D., Xia, B., Sabbaghian, N., Reis-Filho, J. S., Hamel, N., Li, G., van Beers, E. H., Li, L., Khalil, T., Quenneville, L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701724104 · Cited by 211 · see citing works

LEDGF (p75) promotes DNA-end resection and homologous recombination

Daugaard, M., Baude, A., Fugger, K., Povlsen, L. K., Beck, H., Sørensen, C. S., Petersen, N. H. T., Sorensen, P. H. B., Lukas, C., Bártek, J., et al. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2314 · Cited by 208 · see citing works

Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control

Chen, C.-F., Chen, P.-L., Zhong, Q., Sharp, Z. D., & Lee, W.-H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32931 · Cited by 207 · see citing works

Rad51 Paralog Complexes BCDX2 and CX3 Act at Different Stages in the BRCA1-BRCA2-Dependent Homologous Recombination Pathway

Chun, J., Buechelmaier, E. S., & Powell, S. N. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00465-12 · Cited by 207 · see citing works

Evidence for Simultaneous Protein Interactions between Human Rad51 Paralogs

Schild, D., Lio, Y.-C., Collins, D. W., Tsomondo, T., & Chen, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001473200 · Cited by 199 · see citing works

PALB2/FANCN: Recombining Cancer and Fanconi Anemia

Tischkowitz, M. D., & Xia, B. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1012 · Cited by 196 · see citing works

Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics

Jönsson, G. B., Staaf, J., Vallon‐Christersson, J., Ringnér, M., Holm, K., Hegardt, C., Gunnarsson, H., Fagerholm, R., Strand, C., Agnarsson, B. A., et al. (2010) · Breast Cancer Research · doi:10.1186/bcr2596 · Cited by 193 · see citing works

Interaction between the Product of the Breast Cancer Susceptibility Gene BRCA2 and DSS1, a Protein Functionally Conserved from Yeast to Mammals

Marston, N. J., Richards, W. J., Hughes, D. A., Bertwistle, D., Marshall, C. J., & Ashworth, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4633 · Cited by 186 · see citing works

Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms

Carreira, A., & Kowalczykowski, S. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106971108 · Cited by 185 · see citing works

Rare Mutations in XRCC2 Increase the Risk of Breast Cancer

Park, D. J., Lesueur, F., Nguyen‐Dumont, T., Pertesi, M., Odefrey, F., Hammet, F., Neuhausen, S. L., John, E. M., Andrulis, I. L., Terry, M. B., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.02.027 · Cited by 185 · see citing works

Structural basis for recruitment of BRCA2 by PALB2

Oliver, A. W., Swift, S., Lord, C. J., Ashworth, A., & Pearl, L. H. (2009) · EMBO Reports · doi:10.1038/embor.2009.126 · Cited by 181 · see citing works

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

Orii, K. E., Lee, Y., Kondo, N., & McKinnon, P. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602436103 · Cited by 181 · see citing works

Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes

Dosanjh, M. K. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.5.1179 · Cited by 177 · see citing works

Disruption of muREC2/RAD51L1 in Mice Results in Early Embryonic Lethality Which Can Be Partially Rescued in a p53−/− Background

Shu, Z., Smith, S. T., Wang, L., Rice, M. C., & Kmiec, E. B. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8686 · Cited by 174 · see citing works

The BRC repeats are conserved in mammalian BRCA2 proteins

Bignell, G. R. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.1.53 · Cited by 174 · see citing works

Regulation of DNA Pairing in Homologous RecombinationPreprint

Daley, J. M., Gaines, W. A., Kwon, Y., & Sung, P. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017954 · Cited by 173 · see citing works

Comprehensive Analysis of Missense Variations in the BRCT Domain of BRCA1 by Structural and Functional Assays

Lee, M. S., Green, R., Marsillac, S. M., Coquelle, N., Williams, R. S., Yeung, T., Foo, D., Hau, D., Hui, B., Monteiro, Á. N. A., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4563 · Cited by 170 · see citing works

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

Dray, E. V., Etchin, J., Wiese, C., Saro, D., Williams, G. J., Hammel, M., Yu, X., Galkin, V. E., Liu, D., Tsai, M.-S., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1916 · Cited by 168 · see citing works

Germline Brca2 Heterozygosity Promotes Kras -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer

Skoulidis, F., Cassidy, L. D., Pisupati, V., Jonasson, J. G., Bjarnason, H., Eyfjord, J. E., Karreth, F. A., Lim, M., Barber, L. M., Clatworthy, S. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.015 · Cited by 167 · see citing works

Characterization of a carboxy-terminal BRCA1 interacting protein

Wong, A. K. C., Ormonde, P. A., Pero, R. S., Chen, Y., Lian, L., Salada, G. C., Berry, S., Lawrence, Q. A., Dayananth, P., Ha, P. C., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202150 · Cited by 162 · see citing works

Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cellsPreprint

Couëdel, C., Mills, K. D., Barchi, M., Shen, L., Olshen, A. B., Johnson, R. D., Nussenzweig, A., Essers, J., Kanaar, R., Li, G. C., et al. (2004) · Genes & Development · doi:10.1101/gad.1209204 · Cited by 159 · see citing works

Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13.

Guðmundsson, J., Jóhannesdóttir, G., Bergþorsson, J. Þ., Arason, A., Ingvarsson, S., Egilsson, V., & Barkardottir, R. B. (1995) · PubMed · Cited by 156 · see citing works

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

Neibergs, H. L. (2004) · The Women s Oncology Review · doi:10.1080/14733400410001682970 · Cited by 152 · see citing works

The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family

Cartwright, R. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.13.3084 · Cited by 147 · see citing works

Biallelic Deleterious BRCA1 Mutations in a Woman with Early-Onset Ovarian Cancer

Domchek, S. M., Tang, J.-B., Stopfer, J. E., Lilli, D. R., Hamel, N., Tischkowitz, M. D., Monteiro, Á. N. A., Messick, T. E., Powers, J., Yonker, A., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0421 · Cited by 146 · see citing works

ATP Hydrolysis by Mammalian RAD51 Has a Key Role during Homology-directed DNA Repair

Stark, J. M., Hu, P., Pierce, A. J., Moynahan, M. E., Ellis, N. A., & Jasin, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112132200 · Cited by 144 · see citing works

RAD51C-Deficient Cancer Cells Are Highly Sensitive to the PARP Inhibitor Olaparib

Min, A., Im, S., Yoon, Y., Song, S., Nam, H.-J., Hur, H.-S., Kim, H., Lee, K.-H., Han, S., Oh, D., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0950 · Cited by 143 · see citing works

A High-Throughput Functional Complementation Assay for Classification of <i>BRCA1</i> Missense Variants

Bouwman, P., van der Gulden, H., van der Heijden, I., Drost, R., Klijn, C. N., Prasetyanti, P., Pieterse, M., Wientjens, E., Seibler, J., Hogervorst, F. B. L., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0094 · Cited by 140 · see citing works

BRCA2 BRC motifs bind RAD51–DNA filaments

Galkin, V. E., Esashi, F., Yu, X., Yang, S., West, S. C., & Egelman, E. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407266102 · Cited by 139 · see citing works

Mouse embryonic stem cell–based functional assay to evaluate mutations in BRCA2

Kuznetsov, S. G., Liu, P., & Sharan, S. K. (2008) · Nature Medicine · doi:10.1038/nm.1719 · Cited by 139 · see citing works

Identification, Characterization, and Genetic Mapping ofRad51d,a New Mouse and HumanRAD51/RecA-Related Gene

Pittman, D. L., Weinberg, L. R., & Schimenti, J. C. (1998) · Genomics · doi:10.1006/geno.1998.5226 · Cited by 138 · see citing works

Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas.

Schoenmakers, E., Huysmans, C., & Wj, V. D. V. (1999) · PubMed · Cited by 138 · see citing works

Detection of Protein Folding Defects Caused by BRCA1-BRCT Truncation and Missense Mutations

Williams, R. S., Chasman, D. I., Hau, D., Hui, B., Lau, A. Y., & Glover, J. N. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310182200 · Cited by 138 · see citing works

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females

Kuznetsov, S. G., Pellegrini, M., Shuda, K., Fernández-Capetillo, Ó., Liu, Y., Martin, B. K., Burkett, S. S., Southon, E. A., Pati, D., Tessarollo, L., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608130 · Cited by 136 · see citing works

BRCAness revisited

Lord, C. J., & Ashworth, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.21 · Cited by 1,257 · see citing works

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

Davies, H., Glodzik, D., Morganella, S., Yates, L. R., Staaf, J., Zou, X., Ramakrishna, M., Martin, S., Boyault, S., Sieuwerts, A. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4292 · Cited by 1,086 · see citing works

Homologous recombination and the repair of DNA double-strand breaks

Wright, W. D., Shah, S. S., & Heyer, W.-D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000372 · Cited by 713 · see citing works

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

Polak, P., Kim, J., Braunstein, L. Z., Karlic, R., Haradhavala, N. J., Tiao, G., Rosebrock, D., Livitz, D., Kübler, K., Mouw, K. W., et al. (2017) · Nature Genetics · doi:10.1038/ng.3934 · Cited by 531 · see citing works

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

Zhao, W., Steinfeld, J. B., Liang, F., Chen, X., Maranon, D. G., Jian Ma, C., Kwon, Y., Rao, T., Wang, W., Sheng, C., et al. (2017) · Nature · doi:10.1038/nature24060 · Cited by 393 · see citing works

DNA Damage in Stem Cells

Vitale, I., Manic, G., De Maria, R., Kroemer, G., & Galluzzi, L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.006 · Cited by 361 · see citing works

Hereditary breast and ovarian cancer: new genes in confined pathways

Nielsen, F. C., van Overeem Hansen, T., & Sørensen, C. S. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.72 · Cited by 367 · see citing works

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Choe, K. N., & Moldovan, G.-L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.020 · Cited by 325 · see citing works

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Krajewska, M., Dries, R., Grassetti, A. V., Dust, S., Gao, Y., Huang, H., Sharma, B., Day, D. S., Kwiatkowski, N., Pomaville, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09703-y · Cited by 281 · see citing works

Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy

Samstein, R. M., Krishna, C., Ma, X., Pei, X., Lee, K.-W., Makarov, V., Kuo, F., Chung, J., Srivastava, R. M., Purohit, T. A., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00139-8 · Cited by 219 · see citing works

The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors

Peng, Y., Liao, Q., Tan, W., Peng, C., Hu, Z., Chen, Y., Li, Z., Li, J., Zhen, B., Zhu, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09232-8 · Cited by 104 · see citing works

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., et al. (2018) · Genome Biology · doi:10.1186/s13059-018-1401-9 · Cited by 67 · see citing works

Targeting DNA Damage Response and Immune Checkpoint for Anticancer Therapy

Huang, J.-L., Chang, Y.-T., Hong, Z.-Y., & Lin, C.-S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063238 · Cited by 42 · see citing works

Breast cancer: miRNAs monitoring chemoresistance and systemic therapy

Singh, S., Saini, H., Sharma, A., Gupta, S., Huddar, V. G., & Tripathi, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1155254 · Cited by 25 · see citing works

Overexpressed of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability

Schild, D., & Wiese, C. (2009) · doi:10.2172/983266

USP22 Interacts with PALB2 and Promotes Chemotherapy Resistance via Homologous Recombination of DNA Double-Strand Breaks

Nardi, I. K., Stark, J. M., Larsen, A. B., Salgia, R., & Raz, D. J. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0053 · Cited by 28 · see citing works

Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability

Schild, D., & Wiese, C. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1063 · Cited by 110 · see citing works

SURVEY AND SUMMARY Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability

Schild, D., & Wiese, C. (2009)

The canine RAD51 mutation leads to the attenuation of interaction with PALB2

Uemura, M., Ochiai, K., Morimatsu, M., et al. (2019) · Veterinary and Comparative Oncology · doi:10.1111/vco.12542 · Cited by 6 · see citing works