Cited by 165Chromosomal and Genetic VariationsBat Biology and Ecology StudiesGenomic variations and chromosomal abnormalities

Multiple waves of recent DNA transposon activity in the bat, Myotis lucifugus

Open access
Ray, David A., Feschotte, Cedric, Pagan, Heidi J.T., Smith, Jeremy D., Pritham, Ellen J., Arensburger, Peter, Atkinson, Peter W., Craig, Nancy L.·2008·Genome Research

Abstract

DNA transposons, or class 2 transposable elements, have successfully propagated in a wide variety of genomes. However, it is widely believed that DNA transposon activity has ceased in mammalian genomes for at least the last 40 million years. We recently reported evidence for the relatively recent activity of hAT and Helitron elements, two distinct groups of DNA transposons, in the lineage of the vespertilionid bat Myotis lucifugus. Here, we describe seven additional families that have also been recently active in the bat lineage. Early vespertilionid genome evolution was dominated by the activity of Helitron s, mariner-like and Tc2-like elements. This was followed by the colonization of Tc1-like elements, and by a more recent explosion of hAT-like elements. Finally, and most recently, piggyBac-like elements have amplified within the Myotis genome and our results indicate that one of these families is probably still expanding in natural populations. Together, these data suggest that there has been tremendous recent activity of various DNA transposons in the bat lineage that far exceeds those previously reported for any mammalian lineage. The diverse and recent populations of DNA transposons in genus Myotis will provide an unprecedented opportunity to study the impact of this class of elements on mammalian genome evolution and to better understand what makes some species more susceptible to invasion by genomic parasites than others.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/gr.071886.107

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The genomes of long-lived bats are replete with transposable elements.

    “whereas the genomes of long-lived bats are replete with transposable elements109.”

    From The role of retrotransposable elements in ageing and age-associated diseases (2021) · cites this paper as [109]

    The Discussion reports diverse DNA transposons in vespertilionid bats and estimates that the families studied account for at least 3.5% of the available Myotis genome data. It does not identify the bats studied as long-lived or establish the claim for long-lived bats generally. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ray, D. A., Feschotte, C., Pagan, H. J. T., Smith, J. D., Pritham, E. J., Arensburger, P., Atkinson, P. W., & Craig, N. L.
Affiliations
  • West Virginia University (US)
  • The University of Texas at Arlington (US)
  • University of California, Riverside (US)
  • Howard Hughes Medical Institute (US)
Venue
Genome Research
Published
2008-03-13
Volume
18
Issue
5
Pages
717-728
ISSN
1088-9051 (ISSN-L)
OpenAlex
W1969997303
Cited by
165
References
51
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 17 · 2014: 12 · 2013: 11 · 2012: 12
Type
posted content
Language
en
Open access
Locations
  • Genome Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • Texas Tech University
  • Louisiana State University
  • West Virginia University
  • University of Texas at Arlington
  • Broad Institute
  • National Institute of General Medical Sciences (R01 GM 77582-01, R01GM076425, R01GM077582)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Bat Biology and Ecology Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Keywords
DNA transposons, Myotis lucifugus, bats, Helitrons, mariner-like elements, transposable element activity, genomic parasites, mammalian genome evolution, Vespertilionidae
MeSH terms
Animals, Chiroptera, DNA Transposable Elements, Phylogeny, Species Specificity, Genetic Variation, Mutagenesis, Insertional, Evolution, Molecular, Transposases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review