Multiple waves of recent DNA transposon activity in the bat, Myotis lucifugus
Open accessAbstract
DNA transposons, or class 2 transposable elements, have successfully propagated in a wide variety of genomes. However, it is widely believed that DNA transposon activity has ceased in mammalian genomes for at least the last 40 million years. We recently reported evidence for the relatively recent activity of hAT and Helitron elements, two distinct groups of DNA transposons, in the lineage of the vespertilionid bat Myotis lucifugus. Here, we describe seven additional families that have also been recently active in the bat lineage. Early vespertilionid genome evolution was dominated by the activity of Helitron s, mariner-like and Tc2-like elements. This was followed by the colonization of Tc1-like elements, and by a more recent explosion of hAT-like elements. Finally, and most recently, piggyBac-like elements have amplified within the Myotis genome and our results indicate that one of these families is probably still expanding in natural populations. Together, these data suggest that there has been tremendous recent activity of various DNA transposons in the bat lineage that far exceeds those previously reported for any mammalian lineage. The diverse and recent populations of DNA transposons in genus Myotis will provide an unprecedented opportunity to study the impact of this class of elements on mammalian genome evolution and to better understand what makes some species more susceptible to invasion by genomic parasites than others.
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The genomes of long-lived bats are replete with transposable elements.
“whereas the genomes of long-lived bats are replete with transposable elements109.”
From The role of retrotransposable elements in ageing and age-associated diseases (2021) · cites this paper as [109]
The Discussion reports diverse DNA transposons in vespertilionid bats and estimates that the families studied account for at least 3.5% of the available Myotis genome data. It does not identify the bats studied as long-lived or establish the claim for long-lived bats generally. (LLM, conf=0.86)
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- Authors
- Ray, D. A., Feschotte, C., Pagan, H. J. T., Smith, J. D., Pritham, E. J., Arensburger, P., Atkinson, P. W., & Craig, N. L.
- Affiliations
- West Virginia University (US)
- The University of Texas at Arlington (US)
- University of California, Riverside (US)
- Howard Hughes Medical Institute (US)
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-03-13
- Volume
- 18
- Issue
- 5
- Pages
- 717-728
- ISSN
- 1088-9051 (ISSN-L)
- PMC
- PMC2336803
- OpenAlex
- W1969997303
- Cited by
- 165
- References
- 51
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 17 · 2014: 12 · 2013: 11 · 2012: 12
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genome Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Texas Tech University
- Louisiana State University
- West Virginia University
- University of Texas at Arlington
- Broad Institute
- National Institute of General Medical Sciences (R01 GM 77582-01, R01GM076425, R01GM077582)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Bat Biology and Ecology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- DNA transposons, Myotis lucifugus, bats, Helitrons, mariner-like elements, transposable element activity, genomic parasites, mammalian genome evolution, Vespertilionidae
- MeSH terms
- Animals, Chiroptera, DNA Transposable Elements, Phylogeny, Species Specificity, Genetic Variation, Mutagenesis, Insertional, Evolution, Molecular, Transposases
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