Dynamic interactions between transposable elements and their hosts
Open accessAbstract
Transposable elements (TEs) have a unique ability to mobilize to new genomic locations, and the major advance of second-generation DNA sequencing has provided insights into the dynamic relationship between TEs and their hosts. It now is clear that TEs have adopted diverse strategies - such as specific integration sites or patterns of activity - to thrive in host environments that are replete with mechanisms, such as small RNAs or epigenetic marks, that combat TE amplification. Emerging evidence suggests that TE mobilization might sometimes benefit host genomes by enhancing genetic diversity, although TEs are also implicated in diseases such as cancer. Here, we discuss recent findings about how, where and when TEs insert in diverse organisms.
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Under normal conditions, surveillance mechanisms including those associated with DNA repair and chromatin remodeling function to repress TE activity and largely maintain genomic stability.
“Under normal conditions, surveillance mechanisms including those associated with DNA repair and chromatin remodeling function to repress TE activity and largely maintain genomic stability [243]”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [243]
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“Under normal conditions, surveillance mechanisms including those associated with DNA repair and chromatin remodeling function to repress TE activity and largely maintain genomic stability (Levin and Moran, 2011).”
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- Authors
- Levin, H. L., & Moran, J. V.
- Affiliations
- National Institutes of Health (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Levin, Henry L.
- Moran, John V.
- Venue
- Nature Reviews Genetics
- Published
- 2011-08-18
- Volume
- 12
- Issue
- 9
- Pages
- 615-627
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC3192332
- OpenAlex
- W2035260243
- Cited by
- 621
- References
- 197
- Citations by year
- 2026: 17 · 2025: 34 · 2024: 41 · 2023: 27 · 2022: 38 · 2021: 38 · 2020: 42 · 2019: 47 · 2018: 39 · 2017: 53 · 2016: 61 · 2015: 54 · 2014: 46 · 2013: 44 · 2012: 37
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (Z99HD999999, Z99 HL999999, Z99 MH999999, Z99 OD999999, Z99 DA999999)
- National Institute of General Medical Sciences (GM082970, R01GM082970, GM060518, R01GM060518)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD001009)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- transposable elements, transposon-host interactions, transposon integration sites, host defense, small RNA, epigenetic silencing, genetic diversity, cancer, eukaryotes, bacteria
- MeSH terms
- DNA Transposable Elements, DNA Repair, Heterochromatin, Humans, RNA, Messenger, Genetic Variation, Genome, Human, Telomere, Sequence Analysis, DNA, Genome, Plant, Evolution, Molecular, DNA Methylation, RNA, Small Interfering, Epigenomics
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