Cited by 621Chromosomal and Genetic VariationsGenomics and Chromatin DynamicsBacterial Genetics and Biotechnology

Dynamic interactions between transposable elements and their hosts

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Levin, Henry L., Moran, John V.·2011·Nature Reviews Genetics

Abstract

Transposable elements (TEs) have a unique ability to mobilize to new genomic locations, and the major advance of second-generation DNA sequencing has provided insights into the dynamic relationship between TEs and their hosts. It now is clear that TEs have adopted diverse strategies - such as specific integration sites or patterns of activity - to thrive in host environments that are replete with mechanisms, such as small RNAs or epigenetic marks, that combat TE amplification. Emerging evidence suggests that TE mobilization might sometimes benefit host genomes by enhancing genetic diversity, although TEs are also implicated in diseases such as cancer. Here, we discuss recent findings about how, where and when TEs insert in diverse organisms.

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  • Under normal conditions, surveillance mechanisms including those associated with DNA repair and chromatin remodeling function to repress TE activity and largely maintain genomic stability.

    “Under normal conditions, surveillance mechanisms including those associated with DNA repair and chromatin remodeling function to repress TE activity and largely maintain genomic stability [243]”

    From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [243]

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Research works printed but not linked: 4

  1. [40]Craig NL Craigie R Gellert M Lambowitz AM Mobile DNA II 2002 Washington, D.C. ASM Press
  2. [57]Rio DC Craig NL Craigie R Gellert M Lambowitz AM Mobile DNA II 2002 Washington, D.C. ASM Press 484 518
  3. [76]Craig NL Craig NL Craigie R Gellert M Lambowitz AM Mobile DNA II 2002 Washington, D.C. ASM Press 423 456
  4. [181]Federoff N Craig NL Craigie R Gellert M Lambowitz AM Mobile DNA II 2002 Washington, D.C. ASM Press 997 1007

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Authors
Levin, H. L., & Moran, J. V.
Affiliations
  • National Institutes of Health (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
  • Levin, Henry L.
  • Moran, John V.
Venue
Nature Reviews Genetics
Published
2011-08-18
Volume
12
Issue
9
Pages
615-627
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2035260243
Cited by
621
References
197
Citations by year
2026: 17 · 2025: 34 · 2024: 41 · 2023: 27 · 2022: 38 · 2021: 38 · 2020: 42 · 2019: 47 · 2018: 39 · 2017: 53 · 2016: 61 · 2015: 54 · 2014: 46 · 2013: 44 · 2012: 37
FWCI
4.17
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health (Z99HD999999, Z99 HL999999, Z99 MH999999, Z99 OD999999, Z99 DA999999)
  • National Institute of General Medical Sciences (GM082970, R01GM082970, GM060518, R01GM060518)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD001009)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
transposable elements, transposon-host interactions, transposon integration sites, host defense, small RNA, epigenetic silencing, genetic diversity, cancer, eukaryotes, bacteria
MeSH terms
DNA Transposable Elements, DNA Repair, Heterochromatin, Humans, RNA, Messenger, Genetic Variation, Genome, Human, Telomere, Sequence Analysis, DNA, Genome, Plant, Evolution, Molecular, DNA Methylation, RNA, Small Interfering, Epigenomics

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