The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives
Open accessAbstract
While most Ascomycetes tend to associate principally with plants, the dimorphic fungi Coccidioides immitis and Coccidioides posadasii are primary pathogens of immunocompetent mammals, including humans. Infection results from environmental exposure to Coccidiodies, which is believed to grow as a soil saprophyte in arid deserts. To investigate hypotheses about the life history and evolution of Coccidioides, the genomes of several Onygenales, including C. immitis and C. posadasii; a close, nonpathogenic relative, Uncinocarpus reesii; and a more diverged pathogenic fungus, Histoplasma capsulatum, were sequenced and compared with those of 13 more distantly related Ascomycetes. This analysis identified increases and decreases in gene family size associated with a host/substrate shift from plants to animals in the Onygenales. In addition, comparison among Onygenales genomes revealed evolutionary changes in Coccidioides that may underlie its infectious phenotype, the identification of which may facilitate improved treatment and prevention of coccidioidomycosis. Overall, the results suggest that Coccidioides species are not soil saprophytes, but that they have evolved to remain associated with their dead animal hosts in soil, and that Coccidioides metabolism genes, membrane-related proteins, and putatively antigenic compounds have evolved in response to interaction with an animal host.
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Cites
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Self-citationGenomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus
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“Identifying genes subject to positive natural selection since two closely related pathogens diverged may identify antigenic compounds ( Esteves et al. 2008 ).”
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Samson, R. A., Yilmaz, N., Houbraken, J., Spierenburg, H., Seifert, K. A., Peterson, S. W., Varga, J., & Frisvad, J. C. (2011) · Studies in Mycology · doi:10.3114/sim.2011.70.04 · Cited by 435
Health and Safety Effects of Airborne Soil Dust in the Americas and Beyond
Tong, D. Q., Gill, T. E., Sprigg, W. A., Van Pelt, R. S., Baklanov, A. A., Barker, B. M., Bell, J. E., Castillo, J., Gassó, S., Gaston, C. J., et al. (2023) · Reviews of Geophysics · doi:10.1029/2021rg000763 · Cited by 131
Self-citationFactors Influencing Distribution of Coccidioides immitis in Soil, Washington State, 2016.
Chow, N. A., Kangiser, D., Gade, L., McCotter, O. Z., Hurst, S., Salamone, A., Wohrle, R., Clifford, W., Kim, S., Salah, Z., et al. (2021) · mSphere · doi:10.1128/msphere.00598-21 · Cited by 46
Fungal Genomes and Insights into the Evolution of the Kingdom
Stajich, J. E. (2017) · The Fungal Kingdom · doi:10.1128/9781555819583.ch29 · Cited by 22
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Metadata
- Authors
- Sharpton, T. J., Stajich, J. E., Rounsley, S. D., Gardner, M. J., Wortman, J. R., Jordar, V. S., Maiti, R., Kodira, C. D., Neafsey, D. E., Zeng, Q., Hung, C.-Y., McMahan, C., Muszewska, A., Grynberg, M., Mandel, M. A., Kellner, E. M., Barker, B. M., Galgiani, J. N., Orbach, M. J., Kirkland, T. N., Cole, G. T., Henn, M. R., Birren, B. W., & Taylor, J. W.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-08-28
- Volume
- 19
- Issue
- 10
- Pages
- 1722-1731
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W2169900015
- Cited by
- 317
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- hybrid
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- Sharpton, T. J., Stajich, J. E., Rounsley, S. D., Gardner, M. J., Wortman, J. R., Jordar, V. S., Maiti, R., Kodira, C. D., Neafsey, D. E., Zeng, Q., Hung, C.-Y., McMahan, C., Muszewska, A., Grynberg, M., Mandel, M. A., Kellner, E. M., Barker, B. M., Galgiani, J. N., Orbach, M. J., . . . Taylor, J. W. (2009). Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives. Genome Research. https://doi.org/10.1101/gr.087551.108
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