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Cited by 164

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Maximum-likelihood estimation of recent shared ancestry (ERSA)

Open access
Huff, Chad D., Witherspoon, David J., Simonson, Tatum S., Xing, Jinchuan, Watkins, W. Scott, Zhang, Yuhua, Tuohy, Therese M., Neklason, Deborah W., Burt, Randall W., Guthery, Stephen L., Woodward, Scott R., Jorde, Lynn B.·2011·Genome Research
DOI 10.1101/gr.115972.110
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Abstract

Accurate estimation of recent shared ancestry is important for genetics, evolution, medicine, conservation biology, and forensics. Established methods estimate kinship accurately for first-degree through third-degree relatives. We demonstrate that chromosomal segments shared by two individuals due to identity by descent (IBD) provide much additional information about shared ancestry. We developed a maximum-likelihood method for the estimation of recent shared ancestry (ERSA) from the number and lengths of IBD segments derived from high-density SNP or whole-genome sequence data. We used ERSA to estimate relationships from SNP genotypes in 169 individuals from three large, well-defined human pedigrees. ERSA is accurate to within one degree of relationship for 97% of first-degree through fifth-degree relatives and 80% of sixth-degree and seventh-degree relatives. We demonstrate that ERSA's statistical power approaches the maximum theoretical limit imposed by the fact that distant relatives frequently share no DNA through a common ancestor. ERSA greatly expands the range of relationships that can be estimated from genetic data and is implemented in a freely available software package.

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Metadata

Authors
Huff, C. D., Witherspoon, D. J., Simonson, T. S., Xing, J., Watkins, W. S., Zhang, Y., Tuohy, T. M., Neklason, D. W., Burt, R. W., Guthery, S. L., Woodward, S. R., & Jorde, L. B.
Venue
Genome Research
Publisher
Cold Spring Harbor Laboratory
Published
2011-02-08
Volume
21
Issue
5
Pages
768-774
ISSN
1088-9051 (ISSN-L)
DOI
10.1101/gr.115972.110
OpenAlex
W1999157624
Cited by
164
References
0
Type
posted content
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Maximum-likelihood estimation of recent shared ancestry (ERSA). https://app.cochat.ai/papers/10.1101/gr.115972.110
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Huff, C. D., Witherspoon, D. J., Simonson, T. S., Xing, J., Watkins, W. S., Zhang, Y., Tuohy, T. M., Neklason, D. W., Burt, R. W., Guthery, S. L., Woodward, S. R., & Jorde, L. B. (2011). Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Research. https://doi.org/10.1101/gr.115972.110

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