The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients
Open accessAbstract
Hepatitis B virus (HBV) infection is a leading risk factor for hepatocellular carcinoma (HCC). HBV integration into the host genome has been reported, but its scale, impact and contribution to HCC development is not clear. Here, we sequenced the tumor and nontumor genomes (>80× coverage) and transcriptomes of four HCC patients and identified 255 HBV integration sites. Increased sequencing to 240× coverage revealed a proportionally higher number of integration sites. Clonal expansion of HBV-integrated hepatocytes was found specifically in tumor samples. We observe a diverse collection of genomic perturbations near viral integration sites, including direct gene disruption, viral promoter-driven human transcription, viral-human transcript fusion, and DNA copy number alteration. Thus, we report the most comprehensive characterization of HBV integration in hepatocellular carcinoma patients. Such widespread random viral integration will likely increase carcinogenic opportunities in HBV-infected individuals.
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Massive genomic rearrangement acquired in a single catastrophic event during cancer development
Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414
Fast and SNP-tolerant detection of complex variants and splicing in short reads
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Self-citationA comprehensive catalogue of somatic mutations from a human cancer genome
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Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays
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Self-citationColorectal cancer and genetic alterations in the Wnt pathway
Segditsas, S., & Tomlinson, I. (2006) · Oncogene · doi:10.1038/sj.onc.1210059 · Cited by 591
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Cited by
Wooddell, C. I., Yuen, M.-F., Chan, H. L.-Y., Gish, R. G., Locarnini, S. A., Chavez, D., Ferrari, C., Given, B. D., Hamilton, J., Kanner, S. B., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan0241 · Cited by 490
Ahn, S., Jang, S. J., Shim, J. H., Kim, D., Hong, S., Sung, C. O., Baek, D., Haq, F., Ansari, A. A., Lee, S. Y., et al. (2014) · Hepatology · doi:10.1002/hep.27198 · Cited by 424
The landscape of viral associations in human cancers
Zapatka, M., Borozan, I., Brewer, D. S., Iskar, M., Grundhoff, A., Alawi, M., Desai, N., Sültmann, H., Moch, H., Pathogens, P., et al. (2020) · Nature Genetics · doi:10.1038/s41588-019-0558-9 · Cited by 382
Self-citationThe landscape of viral expression and host gene fusion and adaptation in human cancer
Tang, K.-W., Alaei-Mahabadi, B., Samuelsson, T., Lindh, M., & Larsson, E. (2013) · Nature Communications · doi:10.1038/ncomms3513 · Cited by 301
Epigenetic landscape influences the liver cancer genome architecture
Hama, N., Totoki, Y., Miura, F., Tatsuno, K., Saito-Adachi, M., Nakamura, H., Arai, Y., Hosoda, F., Urushidate, T., Ohashi, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03999-y · Cited by 60
Metadata
- Authors
- Jiang, Z., Jhunjhunwala, S., Liu, J., Haverty, P. M., Kennemer, M. I., Guan, Y., Lee, W., Carnevali, P., Stinson, J., Johnson, S., Diao, J., Yeung, S., Jubb, A., Ye, W., Wu, T. D., Kapadia, S. B., de Sauvage, F. J., Gentleman, R. C., Stern, H. M., Seshagiri, S., Pant, K. P., Modrusan, Z., Ballinger, D. G., & Zhang, Z.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-01-20
- Volume
- 22
- Issue
- 4
- Pages
- 593-601
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W2141860194
- Cited by
- 324
- References
- 6
- Type
- posted content
- Language
- en
- Open access
- hybrid
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- Jiang, Z., Jhunjhunwala, S., Liu, J., Haverty, P. M., Kennemer, M. I., Guan, Y., Lee, W., Carnevali, P., Stinson, J., Johnson, S., Diao, J., Yeung, S., Jubb, A., Ye, W., Wu, T. D., Kapadia, S. B., de Sauvage, F. J., Gentleman, R. C., Stern, H. M., . . . Zhang, Z. (2012). The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients. Genome Research. https://doi.org/10.1101/gr.133926.111
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