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Systematic Identification of Novel Protein Domain Families Associated with Nuclear Functions
Open accessAbstract
A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.
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Lupas, A., Van Dyke, M., & Stock, J. (1991) · Science · doi:10.1126/science.252.5009.1162 · Cited by 3,953
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Cited by
Many paths to methyltransfer: a chronicle of convergence
Schubert, H. L., Blumenthal, R. M., & Cheng, X. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00090-2 · Cited by 876
Doyon, Y., Selleck, W., Lane, W. S., Tan, S., & Côté, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1884-1896.2004 · Cited by 597
Carbia-Nagashima, A., Gerez, J., Perez-Castro, C., Paez-Pereda, M., Silberstein, S., Stalla, G. K., Holsboer, F., & Arzt, E. (2007) · Cell · doi:10.1016/j.cell.2007.07.044 · Cited by 318
Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine
Zhang, C., & Hua, Q. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2015.00413 · Cited by 150
Finelli, M. J., Sanchez-Pulido, L., Liu, K. X., Davies, K. E., & Oliver, P. L. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.685222 · Cited by 76
Metadata
- Authors
- Doerks, T., Copley, R. R., Schultz, J., Ponting, C. P., & Bork, P.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-01-01
- Volume
- 12
- Issue
- 1
- Pages
- 47-56
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W1963842907
- Cited by
- 597
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Doerks, T., Copley, R. R., Schultz, J., Ponting, C. P., & Bork, P. (2002). Systematic Identification of Novel Protein Domain Families Associated with Nuclear Functions. Genome Research. https://doi.org/10.1101/gr.203201
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