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Systematic Identification of Novel Protein Domain Families Associated with Nuclear Functions
Open accessAbstract
A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.
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Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
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Predicting coiled coils from protein sequences.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
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Doyon, Y., Selleck, W., Lane, W. S., Tan, S., & Côté, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1884-1896.2004 · Cited by 597
Carbia-Nagashima, A., Gerez, J., Perez-Castro, C., Paez-Pereda, M., Silberstein, S., Stalla, G. K., Holsboer, F., & Arzt, E. (2007) · Cell · doi:10.1016/j.cell.2007.07.044 · Cited by 318
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Zhang, C., & Hua, Q. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2015.00413 · Cited by 150
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CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis
Liu, C., Yang, Q., Zhu, Q., Lu, X., Li, M., Hou, T., Li, Z., Tang, M., Li, Y., Wang, H., et al. (2020) · Theranostics · doi:10.7150/thno.39013 · Cited by 62
Physiological and molecular functions of the cytosolic peptide:N-glycanase
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Miao, X., Wu, J., Chen, H., & Lu, G. (2022) · Nutrients · doi:10.3390/nu14091690 · Cited by 13
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Metadata
- Authors
- Doerks, T., Copley, R. R., Schultz, J., Ponting, C. P., & Bork, P.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-01-01
- Volume
- 12
- Issue
- 1
- Pages
- 47-56
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W1963842907
- Cited by
- 597
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- bronze
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