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Cited by 710

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

CDART: Protein Homology by Domain Architecture

Open access
Geer, Lewis Y., Domrachev, Michael, Lipman, David J., Bryant, Stephen H.·2002·Genome Research

Abstract

The Conserved Domain Architecture Retrieval Tool (CDART) performs similarity searches of the NCBI Entrez Protein Database based on domain architecture, defined as the sequential order of conserved domains in proteins. The algorithm finds protein similarities across significant evolutionary distances using sensitive protein domain profiles rather than by direct sequence similarity. Proteins similar to a query protein are grouped and scored by architecture. Relying on domain profiles allows CDART to be fast, and, because it relies on annotated functional domains, informative. Domain profiles are derived from several collections of domain definitions that include functional annotation. Searches can be further refined by taxonomy and by selecting domains of interest. CDART is available at http://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi .

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Metadata

Authors
Geer, L. Y., Domrachev, M., Lipman, D. J., & Bryant, S. H.
Venue
Genome Research
Published
2002-10-01
Volume
12
Issue
10
Pages
1619-1623
ISSN
  • 1088-9051 (ISSN-L)
  • 1549-5469
OpenAlex
W2045839655
Cited by
710
References
2
Type
posted content
Language
en
Open access
bronze

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