E3 ubiquitin ligases as T cell anergy factors

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The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitroPreprint

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptorPreprint

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CDART: Protein Homology by Domain ArchitecturePreprint

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Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

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Transcriptional Mechanisms Underlying Lymphocyte Tolerance

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

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Identification of the receptor component of the IκBα–ubiquitin ligase

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Cbl-b regulates the CD28 dependence of T-cell activation

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

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Signal-induced ubiquitination of Ikappa Balpha by the F-box protein Slimb/beta -TrCPPreprint

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Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 + T Cells

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Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

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Blocked Ras Activation in Anergic CD4 + T Cells

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The Rel Protein DIF Mediates the Antifungal but Not the Antibacterial Host Defense in Drosophila

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Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

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Role of SCF Ubiquitin-Ligase and the COP9 Signalosome in the N Gene–Mediated Resistance Response to Tobacco mosaic virus

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Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

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Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase

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Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

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v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

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Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

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Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

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Untitled work

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Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

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Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation

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Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

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Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

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Cbl Promotes Ubiquitination of the T Cell Receptor ζ through an Adaptor Function of Zap-70

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Two isoforms of otubain 1 regulate T cell anergy via GRAIL

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Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination

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Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways.

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Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells

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Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness

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Negative Regulation of T Cell Antigen Receptor-mediated Crk-L-C3G Signaling and Cell Adhesion by Cbl-b

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Reduced CD3-mediated protein tyrosine phosphorylation in anergic CD4+ and CD8+ T cells.

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Structural basis of ubiquitylation

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Evidence for Repression of IL-2 Gene Activation in Anergic T Cells

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Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase

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Ectopic B-Raf Expression Enhances Extracellular Signal-regulated Kinase (ERK) Signaling in T Cells and Prevents Antigen-presenting Cell-induced Anergy

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The E3 Ubiquitin Ligase GREUL1 Anteriorizes Ectoderm during Xenopus Development

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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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The Continuing Challenges of Leprosy

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Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

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Ubiquitin signaling in immune responses

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Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development

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Egr-2 and Egr-3 are negative regulators of T cell activation

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The Cbl interactome and its functions

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PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

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HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets

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T‐cell tolerance or function is determined by combinatorial costimulatory signals

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Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

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Regulatory Networks Induced by Live Parasites Impair Both Th1 and Th2 Pathways in Patent Lymphatic Filariasis: Implications for Parasite Persistence

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Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

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Mechanisms of Tolerance Induction by Dendritic Cells In Vivo

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CD4 + CD25 − LAG3 + regulatory T cells controlled by the transcription factor Egr-2

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Molecular mechanisms of CD4+ T-cell anergy

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Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals

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Human ITCH E3 Ubiquitin Ligase Deficiency Causes Syndromic Multisystem Autoimmune Disease

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The Family of IL-10-Secreting CD4+ T Cells

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Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag)

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Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

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Tremelimumab (CP-675,206), a Cytotoxic T Lymphocyte–Associated Antigen 4 Blocking Monoclonal Antibody in Clinical Development for Patients with Cancer

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Yin–Yang of costimulation: crucial controls of immune tolerance and function

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Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients

Takahashi, N., Matsumoto, K., Saito, H., Nanki, T., Miyasaka, N., Kobata, T., Azuma, M., Lee, S., Mizutani, S., & Morio, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803256 · Cited by 156 · see citing works

New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting

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Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins

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A novel pathway down-modulating T cell activation involves HPK-1–dependent recruitment of 14-3-3 proteins on SLP-76

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Rapid Suppression of Cytokine Transcription in Human CD4+CD25− T Cells by CD4+Foxp3+ Regulatory T Cells: Independence of IL-2 Consumption, TGF-β, and Various Inhibitors of TCR Signaling

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The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cellsPreprint

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Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

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Neurotoxicity of Perfluorooctane Sulfonate to Hippocampal Cells in Adult Mice

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mTOR at the crossroads of T cell proliferation and tolerance

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Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b

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Regulatory T Cells and Transplantation Tolerance

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HECT E3s and human disease

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Regulating the regulator: negative regulation of Cbl ubiquitin ligases

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T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain

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Molecular mechanisms of T‐cell tolerance

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The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs

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Global Analysis of O-GlcNAc Glycoproteins in Activated Human T Cells

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RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer

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Efficiency of RNA Interference in the Mouse Hematopoietic System Varies between Cell Types and Developmental Stages

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Allosteric auto‐inhibition and activation of the Nedd4 family E3 ligase Itch

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Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice

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The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells

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Negative signaling contributes to T-cell anergy in trauma patients

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NFAT transcription factors in control of peripheral T cell tolerance

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Mini ReviewNegative regulation of PTK signalling by Cbl proteins

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Targeted Cleavage of Signaling Proteins by Caspase 3 Inhibits T Cell Receptor Signaling in Anergic T Cells

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Adaptation by naïve CD4 + T cells to self-antigen–dependent TCR signaling induces functional heterogeneity and tolerance

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Ubiquitinylation of Igβ Dictates the Endocytic Fate of the B Cell Antigen Receptor

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The induction and maintenance of T cell anergy

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Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors

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Signal-Transducing Adaptor Protein-2 Regulates Integrin-Mediated T Cell Adhesion through Protein Degradation of Focal Adhesion Kinase

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GRAIL: a unique mediator of CD4 T‐lymphocyte unresponsiveness

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Cbl-b in T-cell activation

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A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation

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Fasciola hepatica tegumental antigens induce anergic‐like T cells via dendritic cells in a mannose receptor‐dependent manner

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UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells

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T-Cell Tolerance in Cancer

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Cutting Edge: The Transmembrane E3 Ligase GRAIL Ubiquitinates the Costimulatory Molecule CD40 Ligand during the Induction of T Cell Anergy

Lineberry, N. B., Su, L., Lin, J. T., Coffey, G., Seroogy, C. M., & Fathman, C. G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1622 · Cited by 56 · see citing works

Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors

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Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation

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The HECT-Type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T-Cell Death by Catalyzing EGR2 Ubiquitination

Chen, A., Gao, B., Zhang, J., McEwen, T. J., Ye, S. Q., Zhang, D. D., & Fang, D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00407-09 · Cited by 51 · see citing works

USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein

Chen, S., Yun, F., Yao, Y., Cao, M., Zhang, Y., Wang, J., Song, X., & Qian, Y. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172026 · Cited by 49 · see citing works

Cbl-b Regulates Antigen-Induced TCR Down-Regulation and IFN-γ Production by Effector CD8 T Cells without Affecting Functional Avidity

Shamim, M. H., Nanjappa, S. G., Singh, A., Plisch, E. H., LeBlanc, S. E., Walent, J. H., Svaren, J. P., Seroogy, C. M., & Suresh, M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7233 · Cited by 48 · see citing works

Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapamycin Regulation of GRAIL Expression

Lin, J. T., Lineberry, N. B., Kattah, M. G., Su, L., Utz, P. J., Fathman, C. G., & Wu, L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803986 · Cited by 48 · see citing works

E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+ Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination

Zhao, Y., Guo, H., Qiao, G., Zucker, M., Langdon, W. Y., & Zhang, J. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402434 · Cited by 46 · see citing works

The functions and regulation of Otubains in protein homeostasis and diseases

Zhu, Q., Fu, Y., Li, L., Liu, C. H., & Zhang, L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101303 · Cited by 46 · see citing works

Ubiquitination system and autoimmunity: The bridge towards the modulation of the immune response

Gómez‐Martín, D., Díaz‐Zamudio, M., & Alcocer-Varela, J. C. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2007.11.026 · Cited by 45 · see citing works

ZAP70, too little, too much can lead to autoimmunity*

Ashouri, J. F., Lo, W., Nguyen, T. T. T., Shen, L., & Weiss, A. (2021) · Immunological Reviews · doi:10.1111/imr.13058 · Cited by 44 · see citing works

Integrating human omics data to prioritize candidate genes

Chen, Y., Wu, X., & Jiang, R. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-57 · Cited by 43 · see citing works

Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b

Loeser, S., & Penninger, J. M. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.02.004 · Cited by 43 · see citing works

Immunology of β-Cell Destruction

Torre, D. L., & Lernmark, Å. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_24 · Cited by 42 · see citing works

Up-Regulation of Gene Related to Anergy in Lymphocytes Is Associated with Notch-Mediated Human T Cell Suppression

Kostianovsky, A. M., Maier, L. M., Baecher‐Allan, C., Anderson, A. C., & Anderson, D. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6158 · Cited by 42 · see citing works

Transcriptional regulation of T cell tolerance

Bandyopadhyay, S., Soto-Nieves, N., & Macián, F. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.02.006 · Cited by 42 · see citing works

Cutting Edge: Requirement for TRAF6 in the Induction of T Cell Anergy

King, C. G., Buckler, J. L., Kobayashi, T., Hannah, J., Bassett, G., Kim, T. S., Pearce, E. L., Kim, G. G., Turka, L. A., & Choi, Y. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.34 · Cited by 41 · see citing works

RNF13: an emerging RING finger ubiquitin ligase important in cell proliferation

Jin, X., He, C., Chen, J., & Zhu, D. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07925.x · Cited by 40 · see citing works

Identification of Surrogates of Protection against Yersiniosis in Immersion Vaccinated Atlantic Salmon

Bridle, A. R., Koop, B. F., & Nowak, B. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040841 · Cited by 40 · see citing works

The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways

Carpino, N., Chen, Y., Nassar, N. N., & Oh, H.-W. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.08.015 · Cited by 40 · see citing works

Control of Virus-Specific CD8+T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection

Ou, R., Zhang, M., Huang, L., & Moskophidis, D. (2008) · Journal of Virology · doi:10.1128/jvi.01350-07 · Cited by 40 · see citing works

Molecular basis for checkpoints in the CD8 T cell response: Tolerance versus activation

Mescher, M. F., Agarwal, P., Casey, K. A., Hammerbeck, C. D., Xiao, Z., & Curtsinger, J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.02.007 · Cited by 39 · see citing works

The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility

Ramón, H. E., Riling, C. R., Bradfield, J. P., Yang, B., Hakonarson, H. H., & Oliver, P. M. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.69 · Cited by 38 · see citing works

p85β phosphoinositide 3-kinase regulates CD28 coreceptor function

Alcázar, I., Cortés, I., Zaballos, Á., Hernandez, C., Fruman, D. A., Barber, D. F., & Carrera, A. C. (2009) · Blood · doi:10.1182/blood-2008-04-152942 · Cited by 38 · see citing works

Flow Cytometry Contributions for the Diagnosis and Immunopathological Characterization of Primary Immunodeficiency Diseases With Immune Dysregulation

Cabral-Marques, O., Schimke, L. F., de Oliveira, E. B., Khawanky, N. E., Ramos, R. N., al-Ramadi, B. K., Segundo, G. R. S., Ochs, H. D., & Condino‐Neto, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02742 · Cited by 39 · see citing works

SOCS-6 Negatively Regulates T Cell Activation through Targeting p56 to Proteasomal Degradation

Choi, Y. B., Son, M., Park, M., Shin, J., & Yun, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.073726 · Cited by 37 · see citing works

Lysosomal ubiquitin and the demise of Mycobacterium tuberculosis

Purdy, G. E., & Russell, D. G. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01039.x · Cited by 35 · see citing works

Mutation in ITCH Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure

Kleine-Eggebrecht, N., Staufner, C., Kathemann, S., Elgizouli, M., Kopajtich, R., Prokisch, H., & Lainka, E. (2019) · PEDIATRICS · doi:10.1542/peds.2018-1554 · Cited by 34 · see citing works

NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

Lewis, E. L., Xu, R., Beltra, J., Ngiow, S. F., Cohen, J. B., Telange, R., Crane, A., Sawinski, D. L., Wherry, E. J., & Porrett, P. M. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201599 · Cited by 32 · see citing works

Mechanisms of T Cell Tolerance and Suppression in Cancer Mediated by Tumor-Associated Antigens and Hormones

Adler, A. J. (2007) · Current Cancer Drug Targets · doi:10.2174/156800907780006931 · Cited by 33 · see citing works

Peripheral tolerance in CD8+ T cells

Srinivasan, M., & Frauwirth, K. A. (2009) · Cytokine · doi:10.1016/j.cyto.2009.01.010 · Cited by 32 · see citing works

Chapter 5 Dysregulation of T Cell Peripheral Tolerance in Type 1 Diabetes

Tisch, R., & Wang, B. (2008) · Advances in immunology · doi:10.1016/s0065-2776(08)00805-5 · Cited by 31 · see citing works

Staying calm under provocation

Minton, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1466

Review E3 ubiquitin ligases and their control of T cell autoreactivity

Bonnevier, J. L., Zhang, R., & Mueller, D. L. (2005)

E3 ubiquitin ligases and their control of T cell autoreactivity.

Bonnevier, J. L., Zhang, R., & Mueller, D. L. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1842 · Cited by 14 · see citing works

E3 Ligases in T Cell Anergy—Turning Immune Responses into Tolerance

Heissmeyer, V., & Rao, A. (2004) · Science s STKE · doi:10.1126/stke.2412004pe29 · Cited by 56 · see citing works

In This Issue

(2009) · The Journal of Immunology · doi:10.4049/jimmunol.0990035