The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Widespread RNA Editing of Embedded Alu Elements in the Human Transcriptome
Open accessAbstract
More than one million copies of the ∼300-bp Alu element are interspersed throughout the human genome, with up to 75% of all known genes having Alu insertions within their introns and/or UTRs. Transcribed Alu sequences can alter splicing patterns by generating new exons, but other impacts of intragenic Alu elements on their host RNA are largely unexplored. Recently, repeat elements present in the introns or 3′-UTRs of 15 human brain RNAs have been shown to be targets for multiple adenosine to inosine (A-to-I) editing. Using a statistical approach, we find that editing of transcripts with embedded Alu sequences is a global phenomenon in the human transcriptome, observed in 2674 (∼2%) of all publicly available full-length human cDNAs (n= 128,406), from >250 libraries and >30 tissue sources. In the vast majority of edited RNAs, A-to-I substitutions are clustered within transcribed sense or antisense Alu sequences. Edited bases are primarily associated with retained introns, extended UTRs, or with transcripts that have no corresponding known gene. Therefore,Alu-associated RNA editing may be a mechanism for marking nonstandard transcripts, not destined for translation.
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Cited by
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
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Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
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Metadata
- Authors
- Kim, D. D. Y., Kim, T. T. Y., Walsh, T., Kobayashi, Y., Matise, T. C., Buyske, S., & Gabriel, A.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-09
- Volume
- 14
- Issue
- 9
- Pages
- 1719-1725
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W2062714021
- Cited by
- 538
- References
- 45
- Type
- posted content
- Language
- en
- Open access
- bronze
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