The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Extensive and breed-specific linkage disequilibrium in Canis familiaris
Open accessAbstract
The 156 breeds of registered dogs in the United States offer a unique opportunity to map genes important in disease susceptibility, morphology, and behavior. Linkage disequilibrium (LD) is of current interest for its application in whole genome association mapping, since the extent of LD determines the feasibility of such studies. We have measured LD at five genomic intervals, each 5 Mb in length and composed of five clusters of sequence variants spaced 800 kb-1.6 Mb apart. These intervals are located on canine chromosomes 1, 2, 3, 34, and 37, and none is under obvious selective pressure. Approximately 20 unrelated dogs were assayed from each of five breeds: Akita, Bernese Mountain Dog, Golden Retriever, Labrador Retriever, and Pekingese. At each genomic interval, SNPs and indels were discovered and typed by resequencing. Strikingly, LD in canines is much more extensive than in humans: D′ falls to 0.5 at 400-700 kb in Golden Retriever and Labrador Retriever, 2.4 Mb in Akita, and 3-3.2 Mb in Bernese Mountain Dog and Pekingese. LD in dog breeds is up to 100× more extensive than in humans, suggesting that a correspondingly smaller number of markers will be required for association mapping studies in dogs compared to humans. We also report low haplotype diversity within regions of high LD, with 80% of chromosomes in a breed carrying two to four haplotypes, as well as a high degree of haplotype sharing among breeds.
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The International HapMap Project
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Self-citationThe Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863
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High-resolution haplotype structure in the human genome
Daly, M. J., Rioux, J. D., Schaffner, S. F., Hudson, T. J., & Lander, E. S. (2001) · Nature Genetics · doi:10.1038/ng1001-229 · Cited by 1,717
Prospects for whole-genome linkage disequilibrium mapping of common disease genes
Kruglyak, L. (1999) · Nature Genetics · doi:10.1038/9642 · Cited by 1,416
Self-citationHaplotype tagging for the identification of common disease genes
Johnson, G. C. L., Esposito, L., Barratt, B. J., Smith, A. N., Heward, J., Di Genova, G., Ueda, H., Cordell, H. J., Eaves, I. A., Dudbridge, F., et al. (2001) · Nature Genetics · doi:10.1038/ng1001-233 · Cited by 1,174
Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21
Patil, N., Berno, A. J., Hinds, D. A., Barrett, W. A., Doshi, J. M., Hacker, C. R., Kautzer, C. R., Lee, D. H., Marjoribanks, C., McDonough, D. P., et al. (2001) · Science · doi:10.1126/science.1065573 · Cited by 1,145
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Clark, A. G., Weiss, K. M., Nickerson, D. A., Taylor, S. L., Buchanan, A., Stengård, J., Salomaa, V., Vartiainen, E., Perola, M., Boerwinkle, E., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301977 · Cited by 435 · cited 1×
“The ratio of indels to SNPs found in the dog is ∼1:10, similar to what is reported for the human genome (Clark et al. 1998; Cambien et al. 1999; Crawford et al. 2004).”
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Cited by
Genome sequence, comparative analysis and haplotype structure of the domestic dog
members, B. S. P., Lindblad-Toh, K., Wade, C. M., Mikkelsen, T. S., Karlsson, E. K., Jaffe, D. B., Kamal, M., Clamp, M., Chang, J. L., Kulbokas, E. J., et al. (2005) · Nature · doi:10.1038/nature04338 · Cited by 2,568
Self-citationEfficient mapping of mendelian traits in dogs through genome-wide association
Karlsson, E. K., Baranowska, I., Wade, C. M., Salmon Hillbertz, N. H. C., Zody, M. C., Anderson, N., Biagi, T. M., Patterson, N., Pielberg, G. R., Kulbokas, E. J., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.10 · Cited by 561
Parker, H. G., Dreger, D. L., Rimbault, M., Davis, B. W., Mullen, A. B., Carpintero-Ramirez, G., & Ostrander, E. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.079 · Cited by 435
Self-citation- Invited Review - African Indigenous Cattle: Unique Genetic Resources in a Rapidly Changing World
Mwai, O., Hanotte, O., Kwon, Y.-J., & Cho, S. (2015) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.15.0002r · Cited by 300
Gardner, H. L., Fenger, J. M., & London, C. A. (2016) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022114-110911 · Cited by 215
Metadata
- Authors
- Sutter, N. B., Eberle, M. A., Parker, H. G., Pullar, B. J., Kirkness, E. F., Kruglyak, L., & Ostrander, E. A.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-11-15
- Volume
- 14
- Issue
- 12
- Pages
- 2388-2396
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W1988589573
- Cited by
- 303
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Sutter, N. B., Eberle, M. A., Parker, H. G., Pullar, B. J., Kirkness, E. F., Kruglyak, L., & Ostrander, E. A. (2004). Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Research. https://doi.org/10.1101/gr.3147604
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