Cited by 50Genetic and phenotypic traits in livestockHuman-Animal Interaction StudiesGenetic diversity and population structure

Evolutionary History, Selective Sweeps, and Deleterious Variation in the Dog

Freedman, Adam H., Lohmueller, Kirk E., Wayne, Robert K.·2016·Annual Review of Ecology, Evolution, and Systematics

Abstract

The dog is our oldest domesticate and has experienced a wide variety of demographic histories, including a bottleneck associated with domestication and individual bottlenecks associated with the formation of modern breeds. Admixture with gray wolves, and among dog breeds and populations, has also occurred throughout its history. Likewise, the intensity and focus of selection have varied, from an initial focus on traits enhancing cohabitation with humans, to more directed selection on specific phenotypic characteristics and behaviors. In this review, we summarize and synthesize genetic findings from genome-wide and complete genome studies that document the genomic consequences of demography and selection, including the effects on adaptive and deleterious variation. Consistent with the evolutionary history of the dog, signals of natural and artificial selection are evident in the dog genome. However, conclusions from studies of positive selection are fraught with the problem of false positives given that demographic history is often not taken into account.

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Crossref · 10.1146/annurev-ecolsys-121415-032155

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124 of 124 references verified0 citation errors · 0 not checkable

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  • A selective breeding focus on physical traits only can lead to a decrease in the genetic variability of the species, an accumulation of genes associated with pathologies, and an exaggeration of physical traits to levels that may compromise health.

    “Plus, a selective breeding focus on physical traits only can lead to a decrease in the genetic variability of the species, an accumulation of genes associated with pathologies, and an exaggeration of physical traits to levels that may compromise health [18,19].”

    From Ethical Concerns about Fashionable Dog Breeding (2024) · cites this paper as [19]

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Authors
Freedman, A. H., Lohmueller, K. E., & Wayne, R. K.
Affiliations
  • Harvard University (US)
  • University of California, Los Angeles (US)
Venue
Annual Review of Ecology, Evolution, and Systematics
Published
2016-11-01
Volume
47
Issue
1
Pages
73-96
ISSN
  • 1543-592X (ISSN-L)
  • 1545-2069
OpenAlex
W2336854155
Cited by
50
References
124
Citations by year
2026: 3 · 2025: 2 · 2024: 9 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 4 · 2017: 2
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Locations
Annual Review of Ecology Evolution and Systematics (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Keywords
dogs, domestication, selective sweeps, positive selection, population bottleneck, breed formation, selective breeding, demographic history, dog genome

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