Evolutionary History, Selective Sweeps, and Deleterious Variation in the Dog
Abstract
The dog is our oldest domesticate and has experienced a wide variety of demographic histories, including a bottleneck associated with domestication and individual bottlenecks associated with the formation of modern breeds. Admixture with gray wolves, and among dog breeds and populations, has also occurred throughout its history. Likewise, the intensity and focus of selection have varied, from an initial focus on traits enhancing cohabitation with humans, to more directed selection on specific phenotypic characteristics and behaviors. In this review, we summarize and synthesize genetic findings from genome-wide and complete genome studies that document the genomic consequences of demography and selection, including the effects on adaptive and deleterious variation. Consistent with the evolutionary history of the dog, signals of natural and artificial selection are evident in the dog genome. However, conclusions from studies of positive selection are fraught with the problem of false positives given that demographic history is often not taken into account.
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A selective breeding focus on physical traits only can lead to a decrease in the genetic variability of the species, an accumulation of genes associated with pathologies, and an exaggeration of physical traits to levels that may compromise health.
“Plus, a selective breeding focus on physical traits only can lead to a decrease in the genetic variability of the species, an accumulation of genes associated with pathologies, and an exaggeration of physical traits to levels that may compromise health [18,19].”
From Ethical Concerns about Fashionable Dog Breeding (2024) · cites this paper as [19]
Cites
RNA-Seq: a revolutionary tool for transcriptomics
Wang, Z., Gerstein, M., & Snyder, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2484 · Cited by 13,174 · see citing works
THE GENETICAL STRUCTURE OF POPULATIONS
Wright, S. (1949) · Annals of Eugenics · doi:10.1111/j.1469-1809.1949.tb02451.x · Cited by 6,729 · see citing works
The hitch-hiking effect of a favourable gene
Smith, J. M., & Haigh, J. (1974) · Genetical Research · doi:10.1017/s0016672300014634 · Cited by 3,415 · see citing works
INBREEDING DEPRESSION AND ITS EVOLUTIONARY CONSEQUENCES
Charlesworth, D., & Charlesworth, B. (1987) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.18.110187.001321 · Cited by 3,264 · see citing works
Genome-Wide Mapping of in Vivo Protein-DNA Interactions
Johnson, D. S., Mortazavi, A., Myers, R. M., & Wold, B. (2007) · Science · doi:10.1126/science.1141319 · Cited by 2,927 · see citing works
King, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815 · see citing works
Genome sequence, comparative analysis and haplotype structure of the domestic dog
members, B. S. P., Lindblad-Toh, K., Wade, C. M., Mikkelsen, T. S., Karlsson, E. K., Jaffe, D. B., Kamal, M., Clamp, M., Chang, J. L., Kulbokas, E. J., et al. (2005) · Nature · doi:10.1038/nature04338 · Cited by 2,568 · see citing works
Self-citationA high-coverage genome sequence from an archaic denisovan individual
Meyer, M., Kircher, M., Gansauge, M.-T., Li, H., Racimo, F., Mallick, S., Schraiber, J. G., Jay, F., Prüfer, K., de Filippo, C., et al. (2012) · Science · doi:10.1126/science.1224344 · Cited by 1,967 · see citing works
The Electronic Medical Records and Genomics (eMERGE) Consortium, Wood, A. R., The MIGen Consortium, The PAGE Consortium, Study, T. L. C., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.3097 · Cited by 1,853 · see citing works
Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++
Davydov, E. V., Goode, D. L., Sirota, M., Cooper, G. M., Sidow, A., & Batzoglou, S. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1001025 · Cited by 1,757 · see citing works
Evolution and functional impact of rare coding variation from deep sequencing of human exomes
Tennessen, J. A., Bigham, A. W., O’Connor, T. D., Fu, W., Kenny, E. E., Gravel, S., McGee, S., Do, R., Liu, X., Jun, G., et al. (2012) · Science · doi:10.1126/science.1219240 · Cited by 1,613 · see citing works
Multiple and Ancient Origins of the Domestic Dog
Vilà, C., Savolainen, P., Maldonado, J. E., Amorim, I. R., Rice, J. E., Honeycutt, R. L., Crandall, K. A., Lundeberg, J., & Wayne, R. K. (1997) · Science · doi:10.1126/science.276.5319.1687 · Cited by 1,091 · see citing works
Self-citationHuman-like social skills in dogs?
Hare, B., & Tomasello, M. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.07.003 · Cited by 967 · see citing works
The genomic signature of dog domestication reveals adaptation to a starch-rich diet
Axelsson, E., Ratnakumar, A., Arendt, M.-L., Maqbool, K., Webster, M. T., Perloski, M., Liberg, O., Arnemo, J. M., Hedhammar, Å., & Lindblad-Toh, K. (2013) · Nature · doi:10.1038/nature11837 · Cited by 963 · see citing works
Design and analysis of ChIP-seq experiments for DNA-binding proteins
Kharchenko, P., Tolstorukov, M., & Park, P. J. (2008) · Nature Biotechnology · doi:10.1038/nbt.1508 · Cited by 950 · see citing works
Giresi, P. G., Kim, J., McDaniell, R. M., Iyer, V. R., & Lieb, J. D. (2006) · Genome Research · doi:10.17615/8cez-3e87 · Cited by 949 · see citing works
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
vonHoldt, B. M., Pollinger, J. P., Lohmueller, K. E., Han, E., Parker, H. G., Quignon, P., Degenhardt, J. D., Boyko, A. R., Earl, D. A., Auton, A., et al. (2010) · Nature · doi:10.1038/nature08837 · Cited by 804 · see citing works
Self-citationA Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern
Hoekstra, H. E., Hirschmann, R. J., Bundey, R. A., Insel, P. A., & Crossland, J. P. (2006) · Science · doi:10.1126/science.1126121 · Cited by 716 · see citing works
The Effect of Variation of Fitness
Haldane, J. B. S. (1937) · The American Naturalist · doi:10.1086/280722 · Cited by 680 · see citing works
A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs
Sutter, N. B., Bustamante, C. D., Chase, K., GRAY, M. M., Zhao, K., Zhu, L., Padhukasahasram, B., Karlins, E., Davis, S. R., Jones, P. G., et al. (2007) · Science · doi:10.1126/science.1137045 · Cited by 673 · see citing works
Self-citationAn abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people
Nelson, M. R., Wegmann, D., Ehm, M. G., Kessner, D., St. Jean, P., Verzilli, C., Shen, J., Tang, Z., Bacanu, S.-A., Fraser, D., et al. (2012) · Science · doi:10.1126/science.1217876 · Cited by 647 · see citing works
Positive and Negative Selection on the Human Genome
Fay, J. C., Wyckoff, G. J., & Wu, C. (2001) · Genetics · doi:10.1093/genetics/158.3.1227 · Cited by 646 · see citing works
The Evolution of Animal Domestication
Larson, G., & Fuller, D. Q. (2014) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev-ecolsys-110512-135813 · Cited by 640 · see citing works
Assessing the evolutionary impact of amino acid mutations in the human genome.
Boyko, A. R., Williamson, S. H., Indap, A. R., Degenhardt, J. D., Hernandez, R. D., Lohmueller, K. E., Adams, M. D., Schmidt, S., Sninsky, J. J., Sunyaev, S. R., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000083 · Cited by 628 · see citing works
Self-citationGenome sequencing highlights the dynamic early history of dogs
Freedman, A. H., Gronau, I., Schweizer, R. M., Ortega-Del Vecchyo, D., Han, E., Silva, P. M., Galaverni, M., Fan, Z., Marx, P., Lorente-Galdos, B., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004016 · Cited by 624 · see citing works
Rethinking Dog Domestication by Integrating Genetics, Archeology, and Biogeography
Larson, G., Karlsson, E. K., Perri, A., Webster, M. T., Ho, S. Y. W., Peters, J., Stahl, P. W., Piper, P. J., Lingaas, F., Fredholm, M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203005109 · Cited by 540 · see citing works
Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs
Thalmann, O., Shapiro, B., Cui, P., Schuenemann, V. J., Sawyer, S., Greenfield, D., Germonpré, M., Sablin, M., López‐Giráldez, F., Domingo‐Roura, X., et al. (2013) · Science · doi:10.1126/science.1243650 · Cited by 528 · see citing works
Self-citationPopulation genomics of rapid adaptation by soft selective sweeps
Messer, P. W., & Petrov, D. A. (2013) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2013.08.003 · Cited by 475 · see citing works
Barton, N. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0716 · Cited by 475 · see citing works
Spontaneous Mutation Accumulation Studies in Evolutionary Genetics
Halligan, D. L., & Keightley, P. D. (2009) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev.ecolsys.39.110707.173437 · Cited by 469 · see citing works
A Simple Genetic Architecture Underlies Morphological Variation in Dogs
Boyko, A., Quignon, P., Li, L., Schoenebeck, J., Degenhardt, J. D., Lohmueller, K., Zhao, K., Brisbin, A., Parker, H., Vonholdt, B., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000451 · Cited by 469 · see citing works
Self-citationGenomic and archaeological evidence suggest a dual origin of domestic dogs
Frantz, L., Mullin, V. E., Pionnier-Capitan, M., Lebrasseur, O., Ollivier, M., Perri, A. R., Linderholm, A. E., Mattiangeli, V., Teasdale, M. D., Dimopoulos, E. A., et al. (2016) · Science · doi:10.1126/science.aaf3161 · Cited by 449 · see citing works
Ancient DNA Evidence for Old World Origin of New World Dogs
Leonard, J. A., Wayne, R. K., Wheeler, J. C., Valadez, R., Guillén, S. E., & Vilà, C. (2002) · Science · doi:10.1126/science.1076980 · Cited by 445 · see citing works
Self-citationLarge‐Scale Diversification of Skull Shape in Domestic Dogs: Disparity and Modularity
Drake, A. G., & Klingenberg, C. P. (2010) · The American Naturalist · doi:10.1086/650372 · Cited by 429 · see citing works
Molecular and Evolutionary History of Melanism in North American Gray Wolves
Anderson, T. M., vonHoldt, B. M., Candille, S. I., Musiani, M., Greco, C., Stahler, D. R., Smith, D. W., Padhukasahasram, B., Randi, E., Leonard, J. A., et al. (2009) · Science · doi:10.1126/science.1165448 · Cited by 416 · see citing works
Self-citationGenetic Structure of the Purebred Domestic Dog
Parker, H., Kim, L., Sutter, N., Carlson, S., Lorentzen, T. D., Malek, T. B., Johnson, G. S., DeFrance, H. B., Ostrander, E., & Kruglyak, L. (2004) · Science · doi:10.1126/science.1097406 · Cited by 405 · see citing works
How reliable are empirical genomic scans for selective sweeps?Preprint
Teshima, K. M., Coop, G., & Przeworski, M. (2006) · Genome Research · doi:10.1101/gr.5105206 · Cited by 398 · see citing works
Germonpré, M., Sablin, M., Stevens, R. E., Hedges, R. E. M., Hofreiter, M., Stiller, M., & Després, V. R. (2008) · Journal of Archaeological Science · doi:10.1016/j.jas.2008.09.033 · Cited by 393 · see citing works
Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Pielberg, G., Sigurðsson, S., Fall, T., Seppälä, E. H., Hansen, M. S., Lawley, C., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002316 · Cited by 390 · see citing works
Skoglund, P., Ersmark, E., Palkopoulou, E., & Dalén, L. (2015) · Current Biology · doi:10.1016/j.cub.2015.04.019 · Cited by 380 · see citing works
The distribution of fitness effects of new deleterious amino acid mutations in humans.
Eyre-Walker, A., Woolfit, M., & Phelps, T. (2006) · Genetics · doi:10.1534/genetics.106.057570 · Cited by 377 · see citing works
THE MUTATION LOAD IN SMALL POPULATIONS
Kimura, M., Maruyama, T., & Crow, J. F. (1963) · Genetics · doi:10.1093/genetics/48.10.1303 · Cited by 374 · see citing works
Proportionally more deleterious genetic variation in European than in African populations
Lohmueller, K. E., Indap, A. R., Schmidt, S., Boyko, A. R., Hernandez, R. D., Hubisz, M. J., Sninsky, J. J., White, T. J., Sunyaev, S. R., Nielsen, R., et al. (2008) · Nature · doi:10.1038/nature06611 · Cited by 363 · see citing works
Self-citationThe genetics of pigmentation: from fancy genes to complex traits
Barsh, G. S. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)10031-7 · Cited by 358 · see citing works
Keightley, P. D., & Eyre‐Walker, A. (2007) · Genetics · doi:10.1534/genetics.107.080663 · Cited by 358 · see citing works
A β-Defensin Mutation Causes Black Coat Color in Domestic Dogs
Candille, S. I., Kaelin, C. B., Cattanach, B. M., Yu, B., Thompson, D. A., Nix, M. A., Kerns, J. A., Schmutz, S. M., Millhauser, G. L., & Barsh, G. S. (2007) · Science · doi:10.1126/science.1147880 · Cited by 351 · see citing works
Out of southern East Asia: the natural history of domestic dogs across the world
Wang, G., Zhai, W., Yang, H., Wang, L., Li, Z., Yan-hu, L., Fan, R., Yin, T., Zhu, C., Poyarkov, A. D., et al. (2015) · Cell Research · doi:10.1038/cr.2015.147 · Cited by 350 · see citing works
Parker, H. G., VonHoldt, B. M., Quignon, P., Margulies, E. H., Shao, S., Mosher, D. S., Spady, T. C., Elkahloun, A., Cargill, M., Jones, P. G., et al. (2009) · Science · doi:10.1126/science.1173275 · Cited by 342 · see citing works
Self-citationCoat Variation in the Domestic Dog Is Governed by Variants in Three Genes
Cadieu, É., Neff, M. W., Quignon, P., Walsh, K. F., Chase, K., Parker, H. G., vonHoldt, B. M., Rhue, A., Boyko, A. R., Byers, A., et al. (2009) · Science · doi:10.1126/science.1177808 · Cited by 341 · see citing works
Self-citationExperimental illumination of a fitness landscape
Hietpas, R. T., Jensen, J. D., & Bolon, D. N. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016024108 · Cited by 336 · see citing works
Adaptive Variation in Beach Mice Produced by Two Interacting Pigmentation Genes
Steiner, C., Weber, J. N., & Hoekstra, H. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050219 · Cited by 335 · see citing works
Marsden, C. D., Ortega-Del Vecchyo, D., O’Brien, D. P., Taylor, J. F., Ramirez, O., Vilà, C., Marques-Bonet, T., Schnabel, R. D., Wayne, R. K., & Lohmueller, K. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512501113 · Cited by 333 · see citing works
Self-citationDog behaviour, evolution, and cognition
Miklósi, Á. (2015) · Choice Reviews Online · doi:10.5860/choice.191407 · Cited by 328 · see citing works
Prehistoric genomes reveal the genetic foundation and cost of horse domestication
Schubert, M., Jónsson, H., Chang, D., Der Sarkissian, C., Ermini, L., Ginolhac, A., Albrechtsen, A., Dupanloup, I., Foucal, A., Petersen, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416991111 · Cited by 324 · see citing works
The genomics of selection in dogs and the parallel evolution between dogs and humans
Wang, G.-D., Zhai, W., Yang, H.-C., Fan, R.-X., Cao, X., Zhong, L., Wang, L., Liu, F., Wu, H., Cheng, L.-G., et al. (2013) · Nature Communications · doi:10.1038/ncomms2814 · Cited by 323 · see citing works
A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids.Preprint
Vonholdt, B., Pollinger, J., Earl, D., Knowles, J., Boyko, A., Parker, H., Geffen, E., Pilot, M., Jędrzejewski, W., Jȩdrzejewska, B., et al. (2011) · Genome Research · doi:10.1101/gr.116301.110 · Cited by 322 · see citing works
Self-citationExtensive and breed-specific linkage disequilibrium in Canis familiarisPreprint
Sutter, N. B., Eberle, M. A., Parker, H. G., Pullar, B. J., Kirkness, E. F., Kruglyak, L., & Ostrander, E. A. (2004) · Genome Research · doi:10.1101/gr.3147604 · Cited by 308 · see citing works
The Effects of Deleterious Mutations on Evolution at Linked Sites
Charlesworth, B. (2012) · Genetics · doi:10.1534/genetics.111.134288 · Cited by 304 · see citing works
Leader of the pack: gene mapping in dogs and other model organisms
Karlsson, E. K., & Lindblad‐Toh, K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2382 · Cited by 299 · see citing works
The effect of hitch-hiking on neutral genealogies
Barton, N. H. (1998) · Genetics Research · doi:10.1017/s0016672398003462 · Cited by 292 · see citing works
Estimating the mutation load in human genomes
Henn, B. M., Botigué, L. R., Bustamante, C. D., Clark, A. G., & Gravel, S. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3931 · Cited by 281 · see citing works
The deleterious mutation load is insensitive to recent population history.
Simons, Y. B., Turchin, M. C., Pritchard, J. K., & Sella, G. (2014) · Nature Genetics · doi:10.1038/ng.2896 · Cited by 279 · see citing works
Evolution of Coloration Patterns
Protas, M. E., & Patel, N. H. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175302 · Cited by 272 · see citing works
CRANIAL MORPHOLOGY OF DOMESTIC AND WILD CANIDS: THE INFLUENCE OF DEVELOPMENT ON MORPHOLOGICAL CHANGE
Wayne, R. K. (1986) · Evolution · doi:10.1111/j.1558-5646.1986.tb00467.x · Cited by 271 · see citing works
Self-citationDogs Can Discriminate Emotional Expressions of Human Faces
Müller, C. A., Schmitt, K., Barber, A. L. A., & Huber, L. (2015) · Current Biology · doi:10.1016/j.cub.2014.12.055 · Cited by 271 · see citing works
Complex disease and phenotype mapping in the domestic dog
Hayward, J. J., Castelhano, M. G., Oliveira, K. C., Corey, E. E., Balkman, C. E., Baxter, T. L., Casal, M. L., Fang, M., Garrison, S. J., Kalla, S. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms10460 · Cited by 267 · see citing works
Distance from sub-Saharan Africa predicts mutational load in diverse human genomes
Henn, B. M., Botigué, L. R., Peischl, S., Dupanloup, I., Lipatov, M., Maples, B. K., Martin, A. R., Musharoff, S. A., Cann, H. M., Snyder, M. P., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510805112 · Cited by 257 · see citing works
Distinguishing Between Selective Sweeps and Demography Using DNA Polymorphism Data
Jensen, J. D., Kim, Y., DuMont, V. L. B., Aquadro, C. F., & Bustamante, C. D. (2005) · Genetics · doi:10.1534/genetics.104.038224 · Cited by 252 · see citing works
Higher Levels of Neanderthal Ancestry in East Asians than in Europeans
Wall, J. D., Yang, M. A., Jay, F., Kim, S. K., Durand, E. Y., Stevison, L. S., Gignoux, C., Woerner, A., Hammer, M. F., & Slatkin, M. (2013) · Genetics · doi:10.1534/genetics.112.148213 · Cited by 249 · see citing works
The accumulation of deleterious mutations in rice genomes: a hypothesis on the cost of domestication
Lü, J., Tang, T., Tang, H., Huang, J., Shi, S., & Wu, C. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.01.004 · Cited by 248 · see citing works
Ovodov, N. D., Crockford, S. J., Kuzmin, Y. V., Higham, T., Hodgins, G. W. L., & van der Plicht, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022821 · Cited by 248 · see citing works
Patterns of coding variation in the complete exomes of three Neandertals
Castellano, S., Parra, G., Sánchez-Quinto, F. A., Racimo, F., Kuhlwilm, M., Kircher, M., Sawyer, S., Fu, Q., Heinze, A., Nickel, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405138111 · Cited by 247 · see citing works
Frequent adaptation and the McDonald–Kreitman test
Messer, P. W., & Petrov, D. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220835110 · Cited by 230 · see citing works
Genetic structure in village dogs reveals a Central Asian domestication origin
Shannon, L. M., Boyko, R. H., Castelhano, M. G., Corey, E. E., Hayward, J. J., McLean, C., White, M. E., Said, M. A., Anita, B. A., Ikombe, N. B., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516215112 · Cited by 229 · see citing works
Coulson, T. N., MacNulty, D. R., Stahler, D. R., vonHoldt, B. M., Wayne, R. K., & Smith, D. W. (2011) · Science · doi:10.1126/science.1209441 · Cited by 216 · see citing works
Self-citationWorldwide patterns of genomic variation and admixture in gray wolves
Fan, Z., Silva, P., Gronau, I., Wang, S., Armero, A. S., Schweizer, R. M., Ramirez, O., Pollinger, J., Galaverni, M., Ortega Del-Vecchyo, D., et al. (2016) · Genome Research · doi:10.1101/gr.197517.115 · Cited by 209 · see citing works
Self-citationDo, R., Balick, D. J., Li, H., Adzhubei, I. A., Sunyaev, S. R., & Reich, D. (2015) · Nature Genetics · doi:10.1038/ng.3186 · Cited by 208 · see citing works
Relaxation of selective constraint on dog mitochondrial DNA following domestication
Björnerfeldt, S., Webster, M. T., & Vilà, C. (2006) · Genome Research · doi:10.1101/gr.5117706 · Cited by 203 · see citing works
Role of very slightly deleterious mutations in molecular evolution and polymorphism
Ohta, T. (1976) · Theoretical Population Biology · doi:10.1016/0040-5809(76)90019-8 · Cited by 196 · see citing works
Controlling the False-Positive Rate in Multilocus Genome Scans for Selection
Thornton, K., & Jensen, J. D. (2006) · Genetics · doi:10.1534/genetics.106.064642 · Cited by 179 · see citing works
Hybridization and endangered species protection in the molecular era
Wayne, R. K., & Shaffer, H. B. (2016) · Molecular Ecology · doi:10.1111/mec.13642 · Cited by 174 · see citing works
Self-citationLinkage Disequilibrium and Demographic History of Wild and Domestic Canids
GRAY, M. M., Granka, J. M., Bustamante, C. D., Sutter, N. B., Boyko, A. R., Zhu, L., Ostrander, E. A., & Wayne, R. K. (2009) · Genetics · doi:10.1534/genetics.108.098830 · Cited by 174 · see citing works
Self-citationUnleashing the Canine GenomePreprint
Ostrander, E. A., & Kruglyak, L. (2000) · Genome Research · doi:10.1101/gr.155900 · Cited by 165 · see citing works
Palaeolithic dog skulls at the Gravettian Předmostí site, the Czech Republic
Germonpré, M., Lázničková‐Galetová, M., & Sablin, M. (2011) · Journal of Archaeological Science · doi:10.1016/j.jas.2011.09.022 · Cited by 161 · see citing works
Early human presence in the Arctic: Evidence from 45,000-year-old mammoth remains
Питулько, В. В., Tikhonov, A., Pavlova, E. Y., Nikolskiy, P. A., Kuper, K. E., & Николаевич, П. Р. (2016) · Science · doi:10.1126/science.aad0554 · Cited by 155 · see citing works
The legacy of domestication: accumulation of deleterious mutations in the dog genome
Cruz, F., Vila, C., & Webster, M. T. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn177 · Cited by 154 · see citing works
Genes of domestic mammals augmented by backcrossing with wild ancestors
Vilà, C., Seddon, J. M., & Ellegren, H. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.02.004 · Cited by 153 · see citing works
Genetic hitch-hiking in a subdivided population
Slatkin, M., & Wiehe, T. (1998) · Genetics Research · doi:10.1017/s001667239800319x · Cited by 150 · see citing works
Darwinian and demographic forces affecting human protein coding genesPreprint
Nielsen, R., Hubisz, M. J., Hellmann, I., Torgerson, D. G., Andrés, A. M., Albrechtsen, A., Gutenkunst, R. N., Adams, M. D., Cargill, M., Boyko, A. R., et al. (2009) · Genome Research · doi:10.1101/gr.088336.108 · Cited by 149 · see citing works
Weak Selection and Protein Evolution
Akashi, H. D., Osada, N., & Ohta, T. (2012) · Genetics · doi:10.1534/genetics.112.140178 · Cited by 139 · see citing works
Domestic Dogs and Cancer Research: A Breed-Based Genomics Approach
Davis, B. W., & Ostrander, E. A. (2014) · ILAR Journal · doi:10.1093/ilar/ilu017 · Cited by 137 · see citing works
The distribution of deleterious genetic variation in human populations
Lohmueller, K. E. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.09.005 · Cited by 131 · see citing works
Self-citationEvidence for Variation in the Effective Population Size of Animal Mitochondrial DNA
Piganeau, G., & Eyre‐Walker, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004396 · Cited by 129 · see citing works
Evolutionary genomics of dog domestication
Wayne, R. K., & vonHoldt, B. M. (2012) · Mammalian Genome · doi:10.1007/s00335-011-9386-7 · Cited by 127 · see citing works
Self-citationNew evidence for Upper Palaeolithic small domestic dogs in South-Western Europe
Pionnier-Capitan, M., Bemilli, C., Bodu, P., Célérier, G., Ferrié, J., Fossé, P., Garcià, M., & Vigne, J. (2011) · Journal of Archaeological Science · doi:10.1016/j.jas.2011.02.028 · Cited by 125 · see citing works
Limb morphology of domestic and wild canids: The influence of development on morphologic change
Wayne, R. K. (1986) · Journal of Morphology · doi:10.1002/jmor.1051870304 · Cited by 118 · see citing works
Self-citationGenetic subdivision and candidate genes under selection in North American grey wolves
Schweizer, R. M., vonHoldt, B. M., Harrigan, R. J., Knowles, J. C., Musiani, M., Coltman, D. W., Novembre, J., & Wayne, R. K. (2015) · Molecular Ecology · doi:10.1111/mec.13364 · Cited by 107 · see citing works
Self-citationDemographically-based evaluation of genomic regions under selection in domestic dogs
Freedman, A. H., Schweizer, R. M., Ortega-Del Vecchyo, D., Han, E., Davis, B. W., Gronau, I., Silva, P. M., Galaverni, M., Fan, Z., Marx, P., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005851 · Cited by 104 · see citing works
Self-citationRECOMBINATION AND HITCHHIKING OF DELETERIOUS ALLELES
Hartfield, M., & Otto, S. P. (2011) · Evolution · doi:10.1111/j.1558-5646.2011.01311.x · Cited by 103 · see citing works
Halligan, D. L., Kousathanas, A., Ness, R. W., Harr, B., Eöry, L., Keane, T., Adams, D. J., & Keightley, P. D. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003995 · Cited by 101 · see citing works
Evidence for Hitchhiking of Deleterious Mutations within the Human Genome
Chun, S., & Fay, J. C. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002240 · Cited by 98 · see citing works
Insights into Morphology and Disease from the Dog Genome Project
Schoenebeck, J. J., & Ostrander, E. A. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-012927 · Cited by 89 · see citing works
How do you kill 86 mammoths? Taphonomic investigations of mammoth megasites
Shipman, P. (2014) · Quaternary International · doi:10.1016/j.quaint.2014.04.048 · Cited by 88 · see citing works
Koch, I. J., Clark, M. M., Thompson, M. J., Deere, K. A., Wang, J., Duarte, L., Gnanadesikan, G. E., McCoy, E. L., Rubbi, L., Stahler, D. R., et al. (2015) · Molecular Ecology · doi:10.1111/mec.13480 · Cited by 86 · see citing works
Self-citationFu, W., Gittelman, R. M., Bamshad, M. J., & Akey, J. M. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.09.006 · Cited by 85 · see citing works
Gravel, S. (2016) · Genetics · doi:10.1534/genetics.115.184630 · Cited by 81 · see citing works
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Santiago, E., & Caballero, A. (2004) · Genetics · doi:10.1534/genetics.104.032813 · Cited by 80 · see citing works
The Remarkable Evolutionary History of the Human Amylase Genes
Meisler, M. H., & Ting, C.-N. (1993) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411930040033501 · Cited by 80 · see citing works
The impact of equilibrium assumptions on tests of selection
Crisci, J. L., Poh, Y.-P., Mahajan, S., & Jensen, J. D. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00235 · Cited by 75 · see citing works
Elyashiv, E., Bullaughey, K., Sattath, S., Rinott, Y., Przeworski, M., & Sella, G. (2010) · Genome Research · doi:10.1101/gr.108993.110 · Cited by 74 · see citing works
Gazave, É., Chang, D., Clark, A. G., & Keinan, A. (2013) · Genetics · doi:10.1534/genetics.113.153973 · Cited by 73 · see citing works
Evaluating the performance of selection scans to detect selective sweeps in domestic dogs
Schlamp, F., van der Made, J., Stambler, R., Chesebrough, L., Boyko, A. R., & Messer, P. W. (2015) · Molecular Ecology · doi:10.1111/mec.13485 · Cited by 71 · see citing works
Black coats in an admixed wolf × dog pack is melanism an indicator of hybridization in wolves?
Caniglia, R., Fabbri, E., Greco, C., Galaverni, M., Manghi, L., Boitani, L., Sforzi, A., & Randi, E. (2013) · European Journal of Wildlife Research · doi:10.1007/s10344-013-0703-1 · Cited by 69 · see citing works
Inference of Gorilla Demographic and Selective History from Whole-Genome Sequence Data
McManus, K. F., Kelley, J. L., Song, S., Veeramah, K. R., Woerner, A. E., Stevison, L. S., Ryder, O. A., Great Ape Genome Project, Kidd, J. M., Wall, J. D., et al. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu394 · Cited by 61 · see citing works
Negative-assortative mating for color in wolves
Hedrick, P. W., Smith, D. W., & Stahler, D. R. (2016) · Evolution · doi:10.1111/evo.12906 · Cited by 59 · see citing works
Shipman, P. (2015) · Harvard University Press eBooks · doi:10.4159/9780674425385 · Cited by 57 · see citing works
So many doggone traits: mapping genetics of multiple phenotypes in the domestic dog
Rimbault, M., & Ostrander, E. A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds323 · Cited by 44 · see citing works
Ma, X., Kelley, J. L., Eilertson, K. E., Musharoff, S. A., Degenhardt, J. D., Martins, A. L., Vinař, T., Kosiol, C., Siepel, A. C., Gutenkunst, R. N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077175 · Cited by 34 · see citing works
Pervasive Effects of Aging on Gene Expression in Wild Wolves
Charruau, P., Johnston, R. A., Stahler, D. R., Lea, A. J., Snyder‐Mackler, N., Smith, D. W., vonHoldt, B. M., Cole, S. W., Tung, J., & Wayne, R. K. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw072 · Cited by 30 · see citing works
Self-citationHeterozygote Advantage in a Finite Population: Black Color in Wolves
Hedrick, P. W., Stahler, D. R., & Dekker, D. (2014) · Journal of Heredity · doi:10.1093/jhered/esu024 · Cited by 24 · see citing works
Analysis of the canine brain transcriptome with an emphasis on the hypothalamus and cerebral cortex
Roy, M., Kim, N., Kim, K., Chung, W.-H., Achawanantakun, R., Sun, Y., & Wayne, R. K. (2013) · Mammalian Genome · doi:10.1007/s00335-013-9480-0 · Cited by 23 · see citing works
Self-citationAnalysis of structural diversity in wolf-like canids reveals post-domestication variants
Ramírez, Ó., Olalde, Í., Berglund, J., Lorente-Galdós, B., Hernández-Rodríguez, J., Quilez, J., Webster, M. T., Wayne, R. K., Lalueza‐Fox, C., Vilà, C., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-465 · Cited by 18 · see citing works
Self-citationSerum isoamylase values in normal dogs and dogs with exocrine pancreatic insufficiency
Simpson, J. W., Doxey, D. L., & Brown, R. (1984) · Veterinary Research Communications · doi:10.1007/bf02214725 · Cited by 14 · see citing works
Grimm, D. (2015) · Science · doi:10.1126/science.348.6232.277 · Cited by 5 · see citing works
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Legras, J., Galéote, V., Bigey, F., Camarasa, C., Marsit, S., Nidelet, T., Sanchez, I., Couloux, A., Guy, J., Franco‐Duarte, R., et al. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy066 · Cited by 216 · see citing works
Genetic Costs of Domestication and Improvement
Moyers, B. T., Morrell, P. L., & McKay, J. K. (2018) · Journal of Heredity · doi:10.1093/jhered/esx069 · Cited by 216 · see citing works
Independent domestication events in the blue‐cheese fungus Penicillium roqueforti
Dumas, É., Feurtey, A., de la Vega, R. C. R., Prieur, S. L., Snirc, A., Coton, M., Thierry, A., Coton, E., Piver, M. L., Roueyre, D., et al. (2020) · Molecular Ecology · doi:10.1111/mec.15359 · Cited by 94 · see citing works
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Li, D., Sun, G., Zhang, M., Cao, Y., Zhang, C., Fu, Y., Li, F., Li, G., Jiang, R., Han, R., et al. (2020) · BMC Genomics · doi:10.1186/s12864-020-06900-8 · Cited by 76 · see citing works
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Hoelzel, A. R., Bruford, M. W., & Fleischer, R. C. (2019) · Conservation Genetics · doi:10.1007/s10592-019-01151-x · Cited by 70 · see citing works
Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging
Sándor, S., & Kubinyi, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00948 · Cited by 66 · see citing works
De Novo Mutation Rate Estimation in Wolves of Known Pedigree
Koch, E. M., Schweizer, R. M., Schweizer, T. M., Stahler, D. R., Smith, D. W., Wayne, R. K., & Novembre, J. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz159 · Cited by 64 · see citing works
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Thalmann, O., & Perri, A. R. (2018) · Population genomics · doi:10.1007/13836_2018_27 · Cited by 63 · see citing works
Chen, Z., Ai, F., Zhang, J., Ma, X., Yang, W., Wang, W., Su, Y., Wang, M., Yang, Y. P., Mao, K., et al. (2020) · The Plant Journal · doi:10.1111/tpj.14744 · Cited by 41 · see citing works
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Mooney, J. A., Yohannes, A., & Lohmueller, K. E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019116118 · Cited by 37 · see citing works
Self-citationAccumulation of deleterious mutations in the domestic yak genome
Xie, X., Yang, Y. P., Ren, Q., Ding, X., Bao, P., Yan, B., Yan, X., Han, J., Yan, P., & Qiu, Q. (2018) · Animal Genetics · doi:10.1111/age.12703 · Cited by 36 · see citing works
Bird, D., Jacquemetton, C., Buelow, S. A., Evans, A. W., & Valkenburgh, B. V. (2020) · The Anatomical Record · doi:10.1002/ar.24518 · Cited by 32 · see citing works
The Fecal Microbiota of Dogs Switching to a Raw Diet Only Partially Converges to That of Wolves
Xu, J., Becker, A. A. M. J., Luo, Y. H., Zhang, W., Ge, B., Leng, C., Wang, G., Ding, L., Wang, J., Fu, X., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.701439 · Cited by 27 · see citing works
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Hou, Y., Qi, F., Bai, X., Ren, T., Shen, X., Chu, Q., Zhang, X., & Lu, X. (2020) · BMC Genomics · doi:10.1186/s12864-020-6613-1 · Cited by 25 · see citing works
Genetics of canine myxomatous mitral valve disease
O’Brien, M. J., Beijerink, N., & Wade, C. M. (2021) · Animal Genetics · doi:10.1111/age.13082 · Cited by 29 · see citing works
Neuropeptides as facilitators of domestication
Herbeck, Y. E., & Gulevich, R. G. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2939-2 · Cited by 24 · see citing works
Ethical Concerns about Fashionable Dog Breeding
Menor-Campos, D. J. (2024) · Animals · doi:10.3390/ani14050756 · Cited by 20 · see citing works
“Plus, a selective breeding focus on physical traits only can lead to a decrease in the genetic variability of the species, an accumulation of genes associated with pathologies, and an exaggeration of physical traits to levels that may compromise health [18,19].”
BackgroundBarash, A., Preiss-Bloom, S., Machluf, Y., Fabbri, E., Malkinson, D., Velli, E., Mucci, N., Barash, A., Caniglia, R., Dayan, T., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-34533-w · Cited by 18 · see citing works
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Larsen, P. A., & Matocq, M. D. (2019) · Journal of Mammalogy · doi:10.1093/jmammal/gyy184 · Cited by 16 · see citing works
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Jiang, H. H., Li, B., Ma, Y., Bai, S. Y., Dahmer, T. D., Linacre, A. M. T., & Xu, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-70225-5 · Cited by 15 · see citing works
Trut, L. N., Kharlamova, A. V., Сергеевич, П. А., & Herbeck, Y. E. (2021) · Russian Journal of Genetics · doi:10.1134/s1022795421070140 · Cited by 12 · see citing works
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Self-citation[The domestication of Penicillium cheese fungi].
Ropars, J., Caron, T., Lo, Y., Bennetot, B., & Giraud, T. (2020) · PubMed · doi:10.5802/crbiol.15 · Cited by 8 · see citing works
Carbon and nitrogen isotopic composition of commercial dog food in Brazil
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Amici, F., Meacci, S., Caray, E., Oña, L. S., Liebal, K., & Ciucci, P. (2024) · Animal Cognition · doi:10.1007/s10071-024-01849-7 · Cited by 5 · see citing works
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İnsan Kontrolü Dışındaki Köpekler için Kullanılan Kavramların Karmaşıklığı
Keten, A. (2022) · AVRASYA TERİM DERGİSİ · doi:10.31451/ejatd.1163646 · Cited by 3 · see citing works
YÜCER, H. M., & KIRAN, B. A. (2023) · Academic Platform Journal of Halal Life Style · doi:10.53569/apjhls.1406226 · Cited by 3 · see citing works
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Benítez‐Burraco, A., & Hansen, E. J. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15959 · Cited by 2 · see citing works
Lin, X., Yan, C., Wang, Y., Huang, S., Yu, H., Shih, C., Jiang, J., & Xie, F. (2024) · Molecular Ecology · doi:10.1111/mec.17611 · Cited by 2 · see citing works
Filho, A. L. A., Nardoto, G. B., Galera, L. D. A., de Souza, J. L., Reis, L. S., Hernández, Y. A., Sales, R., Gerardi, D. G., & Martinelli, L. A. (2019) · Isotopes in Environmental and Health Studies · doi:10.1080/10256016.2019.1598986 · Cited by 2 · see citing works
Benítez‐Burraco, A., Uriagereka, J., & Nataf, S. (2023) · Development Genes and Evolution · doi:10.1007/s00427-023-00709-7 · Cited by 4 · see citing works
Mooney, J. A., Yohannes, A., & Lohmueller, K. E. (2020) · doi:10.1101/2020.11.16.385443 · Cited by 1 · see citing works
Self-citationResearch Methods for the Analysis of Visual Emotion Cues in Animals: A Workshop Report
Correia‐Caeiro, C., Zamansky, A., Karl, S., & Bremhorst, A. (2025) · Animals · doi:10.3390/ani15213142 · Cited by 1 · see citing works
Kidd, J. M. (2025) · Mammalian Genome · doi:10.1007/s00335-025-10178-0 · Cited by 1 · see citing works
Are feralization and domestication truly mirror processes?Preprint
Niego, A., & Benítez‐Burraco, A. (2021) · doi:10.31234/osf.io/px9hg
vonHoldt, B. M., Schweizer, R. M., Stahler, D. R., Robinson, J. A., Pires, D., & Koepfli, K. (2023) · Journal of Heredity · doi:10.1093/jhered/esad005
Ha, J. C., Brad, T. L., & Ha, J. C. (2024) · CABI eBooks · doi:10.1079/9781800624566.0004
What We Know, What We Don’t, and Where We’re Going
Ha, J. C., Brad, T. L., & Ha, J. C. (2024) · CABI eBooks · doi:10.1079/9781800624566.0011
Ha, J. C., Brad, T. L., & Ha, J. C. (2024) · CABI eBooks · doi:10.1079/9781800624566.0003
Ha, J. C., Brad, T. L., & Ha, J. C. (2024) · CABI eBooks · doi:10.1079/9781800624566.0002
Ha, J. C., Brad, T. L., & Ha, J. C. (2024) · CABI eBooks · doi:10.1079/9781800624566.0001
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Les mélanomes muqueux canins comme modèle génétique et thérapeutique des mélanomes muqueux humains
Prouteau, A. (2020) · theses.fr (ABES) · doi:10.70675/b9dc1f15z26a2z434az856azc3f2cc489b2e
Evolutionary history and life-history traits influence cause-specific mortality in domestic dogs
Bargas-Galarraga, I., von Hardenberg, A., & González‐Voyer, A. (2026) · Journal of Evolutionary Biology · doi:10.1093/jeb/voag046
- Authors
- Freedman, A. H., Lohmueller, K. E., & Wayne, R. K.
- Affiliations
- Harvard University (US)
- University of California, Los Angeles (US)
- Venue
- Annual Review of Ecology, Evolution, and Systematics
- Publisher
- Annual Reviews
- Published
- 2016-11-01
- Volume
- 47
- Issue
- 1
- Pages
- 73-96
- ISSN
- 1543-592X (ISSN-L)
- 1545-2069
- OpenAlex
- W2336854155
- Cited by
- 50
- References
- 124
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 9 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 4 · 2017: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Ecology Evolution and Systematics (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- dogs, domestication, selective sweeps, positive selection, population bottleneck, breed formation, selective breeding, demographic history, dog genome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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