The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Altered adenosine-to-inosine RNA editing in human cancer
Open accessAbstract
Adenosine-to-inosine (A-to-I) RNA editing was recently shown to be abundant in the human transcriptome, affecting thousands of genes. Employing a bioinformatic approach, we identified significant global hypoediting of Alu repetitive elements in brain, prostate, lung, kidney, and testis tumors. Experimental validation confirmed this finding, showing significantly reduced editing in Alu sequences within MED13 transcripts in brain tissues. Looking at editing of specific recoding and noncoding sites, including in cancer-related genes, a more complex picture emerged, with a gene-specific editing pattern in tumors vs. normal tissues. Additionally, we found reduced RNA levels of all three editing mediating enzymes, ADAR, ADARB1, and ADARB2, in brain tumors. The reduction of ADARB2 correlated with the grade of malignancy of glioblastoma multiforme, the most aggressive of brain tumors, displaying a 99% decrease in ADARB2 RNA levels. Consistently, overexpression of ADAR and ADARB1 in the U87 glioblastoma multiforme cell line resulted in decreased proliferation rate, suggesting that reduced A-to-I editing in brain tumors is involved in the pathogenesis of cancer. Altered epigenetic control was recently shown to play a central role in oncogenesis. We suggest that A-to-I RNA editing may serve as an additional epigenetic mechanism relevant to cancer development and progression.
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Cites
MicroRNA expression profiles classify human cancers
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Hypomethylation distinguishes genes of some human cancers from their normal counterparts
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The epigenetic progenitor origin of human cancer
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RNA Editing by Adenosine Deaminases That Act on RNA
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Modulation of microRNA processing and expression through RNA editing by ADAR deaminases
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Systematic identification of abundant A-to-I editing sites in the human transcriptome
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Self-citationWidespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome
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Systematic identification of abundant A-to-I editing sites in the human transcriptome
Levanon, E., Eisenberg, E., Yelin, R., Nemzer, S., Hallegger, M., Shemesh, R., Fligelman, Z., Shoshan, A., Pollock, Sr., Sztybel, D., et al. (2004) · UCL Discovery (University College London) · Cited by 708
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Cited by
Functions and Regulation of RNA Editing by ADAR Deaminases
Nishikura, K. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-105251 · Cited by 1,242
Stem cell programs in cancer initiation, progression, and therapy resistance
Huang, T., Song, X., Xu, D., Tiek, D., Goenka, A., Wu, B., Sastry, N., Hu, B., & Cheng, S.-Y. (2020) · Theranostics · doi:10.7150/thno.41648 · Cited by 524
The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers
Han, L., Diao, L., Yu, S., Xu, X., Li, J., Zhang, R., Yang, Y., Werner, H. M. J., Eterovic, A. K., Yuan, Y., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.08.013 · Cited by 542
Accurate identification of A-to-I RNA editing in human by transcriptome sequencing
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CircNT5E Acts as a Sponge of miR-422a to Promote Glioblastoma Tumorigenesis
Wang, R., Zhang, S., Chen, X., Li, N., Li, J., Jia, R., Pan, Y., & Liang, H. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0532 · Cited by 298
Metadata
- Authors
- Paz, N., Levanon, E. Y., Amariglio, N., Heimberger, A. B., Ram, Z., Constantini, S., Barbash, Z. S., Adamsky, K., Safran, M., Hirschberg, A., Krupsky, M., Ben-Dov, I., Cazacu, S., Mikkelsen, T., Brodie, C., Eisenberg, E., & Rechavi, G.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-10-01
- Volume
- 17
- Issue
- 11
- Pages
- 1586-1595
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W2138825103
- Cited by
- 346
- References
- 45
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Paz, N., Levanon, E. Y., Amariglio, N., Heimberger, A. B., Ram, Z., Constantini, S., Barbash, Z. S., Adamsky, K., Safran, M., Hirschberg, A., Krupsky, M., Ben-Dov, I., Cazacu, S., Mikkelsen, T., Brodie, C., Eisenberg, E., & Rechavi, G. (2007). Altered adenosine-to-inosine RNA editing in human cancer. Genome Research. https://doi.org/10.1101/gr.6493107
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