The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The Nuclear Receptor Superfamily Has Undergone Extensive Proliferation and Diversification in Nematodes
Open accessAbstract
The nuclear receptor (NR) superfamily is the most abundant class of transcriptional regulators encoded in the Caenorhabditis elegans genome, with >200 predicted genes revealed by the screens and analysis of genomic sequence reported here. This is the largest number of NR genes yet described from a single species, although our analysis of available genomic sequence from the related nematode Caenorhabditis briggsae indicates that it also has a large number. Existing data demonstrate expression for 25% of the C. elegans NR sequences. Sequence conservation and statistical arguments suggest that the majority represent functional genes. An analysis of these genes based on the DNA-binding domain motif revealed that several NR classes conserved in both vertebrates and insects are also represented among the nematode genes, consistent with the existence of ancient NR classes shared among most, and perhaps all, metazoans. Most of the nematode NR sequences, however, are distinct from those currently known in other phyla, and reveal a previously unobserved diversity within the NR superfamily. In C. elegans, extensive proliferation and diversification of NR sequences have occurred on chromosome V, accounting for > 50% of the predicted NR genes. [The sequence data described in this paper have been submitted to the GenBank data library under accession nos.AF083222–AF083225 and AF083251–AF083234.]
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Cites
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BackgroundEvidence for a clade of nematodes, arthropods and other moulting animals
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Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
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Cited by
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics
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Lai, C.-H., Chou, C.-Y., Ch'ang, L.-Y., Liu, C.-S., & Lin, W.-C. (2000) · Genome Research · doi:10.1101/gr.10.5.703 · Cited by 472
Nuclear Hormone Receptor NHR-49 Controls Fat Consumption and Fatty Acid Composition in C. elegans
Gilst, M. R. V., Hadjivassiliou, H., Jolly, A., & Yamamoto, K. R. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030053 · Cited by 428
Antebi, A., Yeh, W.-H., Tait, D., Hedgecock, E. M., & Riddle, D. L. (2000) · Genes & Development · doi:10.1101/gad.14.12.1512 · Cited by 419
Metadata
- Authors
- Sluder, A. E., Mathews, S. W., Hough, D., Yin, V. P., & Maina, C. V.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-02-01
- Volume
- 9
- Issue
- 2
- Pages
- 103-120
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2100221195
- Cited by
- 186
- References
- 8
- Type
- posted content
- Language
- en
- Open access
- bronze
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