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Cited by 22Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

Importance of the GluN2B carboxy-terminal domain for enhancement of social memories

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Jacobs, Stephanie, Wei, Wei, Wang, Deheng, Tsien, Joe Z.·2015·Learning & Memory
DOI 10.1101/lm.038521.115PMC PMC4509920
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Abstract

The N-methyl-D-aspartate (NMDA) receptor is known to be necessary for many forms of learning and memory, including social recognition memory. Additionally, the GluN2 subunits are known to modulate multiple forms of memory, with a high GluN2A:GluN2B ratio leading to impairments in long-term memory, while a low GluN2A:GluN2B ratio enhances some forms of long-term memory. Here, we investigate the molecular motif responsible for the differences in social recognition memory and olfactory memory in the forebrain-specific transgenic GluN2A overexpression mice and the forebrain-specific transgenic GluN2B overexpression mice by using two transgenic mouse lines that overexpress chimeric GluN2 subunits. The transgenic chimeric GluN2 subunit mice were tested for their ability to learn and remember fruit scents, male juveniles of the same strain, females of the same strain, male juveniles of another strain, and rodents of another species. The data presented here demonstrate that the GluN2B carboxy-terminal domain is necessary for enhanced social recognition memory in GluN2B transgenic overexpression mice. Furthermore, the GluN2A carboxy-terminal domain is responsible for the impaired long-term olfactory and social memory observed in the GluN2A overexpression mice.

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  • GluN2B is particularly critical for social behaviors in animal models.

    “Variations in the gene encoding GluN2B have been frequently identified in neuropsychiatric disorders 62, 63, and studies on animal models have shown that GluN2B is particularly critical for social behaviors 61, 64, 65.”

    From Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. (2021) · cites this paper as [65]

    The Conclusions (page not provided) report that the GluN2B carboxy-terminal domain is essential for enhanced social recognition memory in transgenic mice. This supports a role in a specific social-memory task, but not the broader claim that GluN2B is particularly critical for social behaviors generally. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Jacobs, S., Wei, W., Wang, D., & Tsien, J. Z.
Affiliations
Augusta University (US)
Corresponding author
Tsien, Joe Z.
ORCID
Venue
Learning & Memory
Publisher
Cold Spring Harbor Laboratory
Published
2015-07-15
Volume
22
Issue
8
Pages
401-410
ISSN
  • 1072-0502 (ISSN-L)
  • 1549-5485
DOI
10.1101/lm.038521.115
PMC
PMC4509920
OpenAlex
W1875597867
Cited by
22
References
9
Citations by year
2026: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2016: 3
Type
posted content
Language
en
Open access
Licence
cc-by-nc
Locations
  • Learning & Memory (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • NIH
  • Yunnan Province Department of Science and Technology
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
GluN2B, GluN2A, NMDA receptor subunits, C-terminal domain, social recognition memory, olfactory memory, long-term memory, transgenic mice
MeSH terms
Animals, Female, Fruit, Habituation, Psychophysiologic, Learning, Male, Memory Disorders, Mice, Transgenic, Neuropsychological Tests, Odorants, Physical Stimulation, Social Perception, Receptors, N-Methyl-D-Aspartate, Prosencephalon, Recognition, Psychology, Olfactory Perception, Memory, Long-Term

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