Cholinergic modulation of a decrement in social investigation following repeated contacts between mice
Abstract
Social recognition has been inferred from a decline in olfactory investigation of conspecific intruders during repeated or protracted confrontation with a resident rat. A stimulus-response relationship defined by lack of response remains somewhat ambiguous. Since it is likely that behavior continues to be emitted by the resident animal, how behavior reorganizes as the resident becomes familiar with an intruder represents an important issue in the characterization of recognition. We examined the decline in olfactory investigation of ovariectomized females by adult male mice. The duration and frequency of olfactory investigation was measured during four 1 minute confrontations with 10-min intertrial intervals (Training trials). If the same female was presented in each trial, investigation declined to less than 50% of initial levels. Aggressive behavior gradually increased with repeated trials. No decline in investigation or increased aggression was measured when females were changed in each trial. Administration of doses of scopolamine (0.16-1.0 mg/kg, IP) blocked decrements in olfactory investigation in repeated confrontations and significantly reduced aggression. Co-administration of heptylphysostigmine (0.32-5.0 mg/kg, IP) reversed scopolamine's effects on olfactory investigation but not aggression. Acetylcholinesterase inhibitors heptylphysostigmine, galanthamine (0.63-2.5 mg/kg, IP) and tacrine (0.63-10.0 mg/kg, IP) all enhanced the rate of decrement of olfactory investiga…
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Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific.
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
From Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice (2004) · cites this paper as Winslow & Camacho 1995
Cholinergic signaling in the amygdala is necessary for social recognition, social memory formation, social stress responsivity, and fear learning.
“Cholinergic signaling in the amygdala is necessary for social recognition [56], social memory formation [57,58], social stress responsivity [59] and fear learning [60].”
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- Authors
- Winslow, J. T., & Camacho, F.
- ORCID
- Camacho, F.
- Venue
- Psychopharmacology
- Published
- 1995-09
- Volume
- 121
- Issue
- 2
- Pages
- 164-172
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2045405667
- Cited by
- 156
- References
- 43
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 9 · 2016: 8 · 2015: 9 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- social recognition, habituation, cholinergic modulation, acetylcholine, scopolamine, galantamine, tacrine, acetylcholinesterase inhibitors, aggression, olfactory memory, male-female interaction
- MeSH terms
- Aggression, Animals, Behavior, Animal, Female, Interpersonal Relations, Male, Memory, Mice, Inbred Strains, Ovariectomy, Scopolamine, Smell, Tacrine, Mice
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