Cited by 286Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase SignalingMemory and Neural Mechanisms

Integration of biochemical signalling in spines

Kennedy, Mary B., Beale, Holly C., Carlisle, Holly J., Washburn, Lorraine R.·2005·Nature Reviews Neuroscience

Abstract

Short-term and long-term changes in the strength of synapses in neural networks underlie working memory and long-term memory storage in the brain. These changes are regulated by many biochemical signalling pathways in the postsynaptic spines of excitatory synapses. Recent findings about the roles and regulation of the small GTPases Ras, Rap and Rac in spines provide new insights into the coordination and cooperation of different pathways to effect synaptic plasticity. Here, we present an initial working representation of the interactions of five signalling cascades that are usually studied individually. We discuss their integrated function in the regulation of postsynaptic plasticity.

Integrity signals

Registry

Crossref · 10.1038/nrn1685

Cites

125 of 125 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Calcium ions in dendritic spines have an important function in activating signaling cascades that underlie and regulate synaptic plasticity.

    “Calcium ions in dendritic spines have an important function in activating signaling cascades that underlie and regulate synaptic plasticity (Kennedy et al., 2005).”

    From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Kennedy et al., 2005

  • The precise crosstalk and integration of Rho, Cdc42 and Rac is not completely understood.

    “The precise crosstalk and integration is however not completely understood (Kennedy et al., 2005).”

    From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Kennedy et al., 2005

  • SynGAP's broad action on dendritic spine signaling arises from its central location in the NMDAR complex and its promiscuous GAP domain that can regulate various small G-proteins.

    “This broad action of SynGAP on dendritic spine signaling arises from its central location in the NMDAR complex (Kennedy et al., 2005) and its endowment with a promiscuous GAP domain that can regulate a variety of small G-proteins (Krapivinsky et al., 2004; Pena et al., 2008).”

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Authors
Kennedy, M. B., Beale, H. C., Carlisle, H. J., & Washburn, L. R.
Affiliations
California Institute of Technology (US)
Corresponding author
Kennedy, Mary B.
Venue
Nature Reviews Neuroscience
Published
2005-06-01
Volume
6
Issue
6
Pages
423-434
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2005797241
Cited by
286
References
127
Citations by year
2025: 3 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 6 · 2016: 10 · 2015: 10 · 2014: 14 · 2013: 14 · 2012: 38
FWCI
2.35
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders
  • John Douglas French Alzheimer's Foundation
  • National Institutes of Health
  • National Institute on Drug Abuse (R01DA030749)
  • National Institute of Neurological Disorders and Stroke (P01NS044306)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
postsynaptic spines, synaptic plasticity, Ras, rap, Rac, small GTPases, excitatory synapses, working memory, long-term memory, signaling pathways
MeSH terms
Animals, Humans, Neuronal Plasticity, Synapses, Signal Transduction, Calcium Signaling, Dendritic Spines

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