δ Subunit-containing GABAA receptor prevents overgeneralization of fear in adult mice
Open accessAbstract
The role of δ subunit-containing GABAA receptor (GABAA(δ)R) in fear generalization is uncertain. Here, by using mice with or without genetic deletion of GABAA(δ)R and using protocols in which the conditioned tone stimuli were cross presented with different nonconditioned stimuli, we observed that when the two tone stimuli were largely similar, both genotypes froze similarly to either of them. However, when they differed markedly, the knockout mice froze much more than their wild-type littermates to the nonconditioned but not conditioned stimuli. Thus, GABAA(δ)R may prevent inappropriate fear generalization when the incoming stimuli differ clearly from the learned threat.
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Global knockout of δGABAARs impairs discrimination learning.
“There is some evidence that a global knockout of δGABAARs impairs discrimination learning [68], and that the hippocampal δGABAARs may be involved in state-dependency of learning and memory [82], both of which are suggestive of a role for δGABAARs in handling memory interference.”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [68]
δGABAARs play a role in handling memory interference.
“There is some evidence that a global knockout of δGABAARs impairs discrimination learning [68], and that the hippocampal δGABAARs may be involved in state-dependency of learning and memory [82], both of which are suggestive of a role for δGABAARs in handling memory interference.”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [68]
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- Authors
- Zhang, W.-H., Zhou, J., Pan, H.-Q., Wang, X.-Y., Liu, W.-Z., Zhang, J.-Y., Yin, X.-P., & Pan, B.-X.
- Affiliations
- Nanchang University (CN)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-07-17
- Volume
- 24
- Issue
- 8
- Pages
- 381-384
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC5516689
- OpenAlex
- W2734950459
- Cited by
- 17
- References
- 28
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 1
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Learning & Memory (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Natural Science Foundation of China (31160208, 91332123, 81601179)
- National Basic Research Program of China (2014CB846100)
- Program for New Century Excellent Talents in Universities of China
- “555 project,”
- Scientific Project of Jiangxi Province (20143ACB21002, KJLD14013)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fear generalization, fear conditioning, tone stimuli, freezing behavior, threat learning
- MeSH terms
- Acoustic Stimulation, Animals, Anxiety, Auditory Perception, Exploratory Behavior, Fear, Generalization, Psychological, Male, Mice, Inbred C57BL, Neuropsychological Tests, Receptors, GABA-A, Mice, Knockout, Freezing Reaction, Cataleptic
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