The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Activation of the Cannabinoid Receptor Type 1 Decreases Glutamatergic and GABAergic Synaptic Transmission in the Lateral Amygdala of the Mouse
Open accessAbstract
The endogenous cannabinoid system has been shown recently to play a crucial role in the extinction of aversive memories. As the amygdala is presumably involved in this process, we investigated the effects of the cannabinoid receptor agonist WIN 55,212-2 (WIN-2) on synaptic transmission in the lateral amygdala (LA) of wild-type and cannabinoid receptor type 1 (CB1)-deficient mice. Extracellular field potential recordings and patch-clamp experiments were performed in an in vitro slice preparation. We found that WIN-2 reduces basal synaptic transmission and pharmacologically isolated AMPA receptor- and GABA(A) receptor-mediated postsynaptic currents in wild-type, but not in CB1-deficient mice. These results indicate that, in the LA, cannabinoids modulate both excitatory and inhibitory synaptic transmission via CB1. WIN-2-induced changes of paired-pulse ratio and of spontaneous and miniature postsynaptic currents suggest a presynaptic site of action. Inhibition of G(i/o) proteins and blockade of voltage-dependent and G protein-gated inwardly rectifying K(+) channels inhibited WIN-2 action on basal synaptic transmission. In contrast, modulation of the adenylyl cyclase-protein kinase A pathway, and blockade of presynaptic N- and P/Q- or of postsynaptic L- and R/T-type voltage-gated Ca(2+) channels did not affect WIN-2 effects. Our results indicate that the mechanisms underlying cannabinoid action in the LA partly resemble those observed in the nucleus accumbens and differ from those described for the hippocampus.
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“Although activation of CB1R in the BLA causes a decrease in both glutamatergic and GABAergic transmission, there is typically a net reduction in neuronal excitability on application of CB1R agonists, probably due to CB1R-mediated presynaptic inhibition of glutamate release [48,49].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [48]
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Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., et al. (1999) · Science · doi:10.1126/science.283.5400.401 · Cited by 3,628
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728
Self-citationEndogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310
Endocannabinoid Signaling in the Brain
Wilson, R. I., & Nicoll, R. A. (2002) · Science · doi:10.1126/science.1063545 · Cited by 1,280
Molecular Diversity of K+ Channels
COETZEE, W. A., AMARILLO, Y., CHIU, J., CHOW, A., LAU, D., McCORMACK, T., MORENA, H., NADAL, M. S., OZAITA, A., POUNTNEY, D., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11293.x · Cited by 1,095
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,078
Marsicano, G., & Lutz, B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00847.x · Cited by 937
Self-citationKreitzer, A. C., & Regehr, W. G. (2001) · Neuron · doi:10.1016/s0896-6273(01)00246-x · Cited by 899
Ohno‐Shosaku, T., Maejima, T., & Kano, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00247-1 · Cited by 874
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THE EFFECT OF CAABIS SATIVA LEAVES AQUEOUS AD ALCOHOLIC EXTRACTS OCA1 EUROAL DESITY IRATS
Kehtarpour, M., & Tehranipour, M. (2011)
Verdurand, M., Nguyen, V. H., Stark, D., Zahra, D., Grégoire, M., Greguric, I. D., & Zavitsanou, K. (2011)
Changes of CB1 cannabinoid receptor distribution in temporal lobe epilepsy
Karlócai, M. R. (2012) · Semmelweis University Repository (Semmelweis University) · doi:10.14753/se.2013.1784
Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?
Zavala‐Tecuapetla, C., & Rocha, L. (2016) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4939-6355-3_5
Plasticity and Memory in Cerebral Cortex
Finnie, P. S. B., Bear, M. F., & Cooke, S. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21079-1
An integrative overview of the cannabinergic system and mental health
Prospero-Garcia, O. E., Laboratorio de Cannabinoides, D. D. F., Rueda‐Orozco, P. E., Belmont, O. A., Ruiz‐Contreras, A. E., Méndez‐Díaz, M., Departamento de Neurofisiología del Desarrollo y Neurofisiología, I. D. N., & Laboratorio de Neurogenómica Cognitiva, C. D. P. Y. N. (2017) · Salud Mental · doi:10.17711/sm.0185-3325.2017.015
Khan, A. U. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2019.tde-29042019-162811
Phenylethylamine and anandamide – natural psychostimulants
Rać, M. E., Bartoszewicz, M., Safranow, K., Dziedziejko, V., Puchałowicz, K., & Chlubek, D. (2018) · Farmacja Polska · doi:10.32383/farmpol/118764
(2019) · Elsevier eBooks · doi:10.1016/b978-3-437-21882-8.00017-7
(2022) · Elsevier eBooks · doi:10.1016/b978-3-437-21884-2.00033-7
Ostos‐Valverde, A., Sánchez‐Zavaleta, R., Téllez-Vega, E. D., Aguilar-Dorado, A., Herrera-Solís, A., Ruiz‐Contreras, A. E., & García, Ó. P. (2026) · Revista Internacional de Investigación en Adicciones · doi:10.28931/riiad.2026.396
McFadden, M. H. (2018) · theses.fr (ABES) · doi:10.70675/036294d9z53a4z495ez9221ze4fba667c298
Cannabinoid Control of Fear Responses
Landgraf, N. F., Sangroniz-Beltrán, L., Ceprián, M., Reyes-Velásquez, P. A., Huguet, J. E., & Gómez, E. S. (2026) · Springer eBooks · doi:10.1007/978-3-032-12239-1_6
Luan, Y., Wang, S., Gao, Y., Kong, Q., Ma, Z., & Luan, C. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1915122
de Medeiros, P. S., Medeiros, A. C., Macacare, O. T., Silva, W. C. C., Acunha, R. M., Bendaña-Córdoba, F. R., Ullah, F., Ferreira, S. H., de Freitas, R. L., & Coimbra, N. C. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150598
Gawłowska-Sawosz, M., & Rabe‐Jabłońska, J. (2010) · DOAJ (DOAJ: Directory of Open Access Journals)
Metadata
- Authors
- Azad, S. C., Eder, M., Marsicano, G., Lutz, B., Zieglgänsberger, W., & Rammes, G.
- Affiliations
- LMU Klinikum (DE)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-03-01
- Volume
- 10
- Issue
- 2
- Pages
- 116-128
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC196665
- OpenAlex
- W2134429437
- Cited by
- 220
- References
- 51
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 7
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cannabinoid receptor type 1, WIN 55,212-2, lateral amygdala, synaptic transmission, AMPA receptors, GABAA receptor, presynaptic modulation, G protein signaling, inwardly rectifying potassium channels, voltage-gated calcium channels, endocannabinoid system
- MeSH terms
- Amygdala, Analgesics, Animals, Electrophysiology, gamma-Aminobutyric Acid, Male, Mice, Inbred C57BL, Mice, Transgenic, Morpholines, Naphthalenes, Neural Inhibition, Synaptic Transmission, Receptors, Drug, Receptors, GABA-A, Calcium Channels, Potassium Channels, Receptors, AMPA, Patch-Clamp Techniques, Glutamic Acid, Excitatory Postsynaptic Potentials, Receptors, Cannabinoid, Benzoxazines, Mice
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