Which Organic Compounds Could Have Occurred on the Prebiotic Earth?

Miller, S.L.

doi:10.1101/sqb.1987.052.01.005

Cited by 182Origins and Evolution of LifeRNA and protein synthesis mechanismsPaleontology and Stratigraphy of Fossils

Which Organic Compounds Could Have Occurred on the Prebiotic Earth?

Miller, S.L.·1987·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.1987.052.01.005

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Abstract

In the past three decades, a wide variety of experiments have been designed to simulate conditions on the primitive earth and to demonstrate how organic compounds that made up the first living organisms were synthesized. This paper reviews this work and indicates the status of such syntheses. There is too much material to review in detail, and the reader is directed to a number of more complete discussions (Miller and Orgel 1974; Kenyon and Steinman 1969; Lemmon 1970).

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Aspartic acid is one of the more abundant amino acids found in meteorites and synthesized in Miller-Urey type prebiotic simulations.
“It is notable that aspartic acid is one of the more abundant amino acids found in meteorites and synthesized in Miller-Urey type prebiotic simulations [62,63].”
From The eightfold path to non-enzymatic RNA replication (2012) · cites this paper as [63]

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Prebiotic synthesis of organic compounds: A review and new results
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Self-citation
Pre-biotic organic synthesis: laboratory simulation experiments and their significance for the origin of life in the solar system
Engel, M. H. (2011) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.890456 · Cited by 4 · see citing works
Miller-Urey and Beyond: What Have We Learned About Prebiotic Organic Synthesis Reactions in the Past 60 Years?
McCollom, T. M. (2013) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev-earth-040610-133457 · Cited by 135 · see citing works
Prebiotic Organic Synthesis and the Emergence of Life: From the Miller Experiment to the Start of Biological Evolution
Delaye, L., Becerra, A., Velasco, A. M., Islas, S., & Lazcano, A. (2004) · Cellular origin and life in extreme habitats · doi:10.1007/978-94-007-1003-0_16 · Cited by 1 · see citing works

Authors: Miller, S. L.
Affiliations: University of California San Diego (US)
Corresponding author: Miller, S.L.
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 1987-01-01
Volume: 52
Issue: 0
Pages: 17-27
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.1987.052.01.005
OpenAlex: W2017119083
Cited by: 182
References: 0
Citations by year: 2026: 4 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 10 · 2015: 6 · 2013: 7 · 2012: 10
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Aeronautics and Space Administration
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Physical Sciences › Earth and Planetary Sciences › Paleontology › Paleontology and Stratigraphy of Fossils
Keywords: prebiotic chemistry, origin of life, organic synthesis, Miller-Urey experiment, early Earth, nucleotides
MeSH terms: Origin of Life, Amino Acids, Catalysis, Purines, Pyrimidines, Radiation Effects, Thermodynamics

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Which Organic Compounds Could Have Occurred on the Prebiotic Earth?

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