The DOI matches its Crossref record.
Expression of Neural Proteoglycans Correlates with the Acquisition of Mature Neuronal Properties in the Mammalian Brain
Abstract
The neurons in the mature mammalian central nervous system (CNS) are an enormously diverse group of cells. The acquisition of mature, differentiated neuronal properties takes place over an extended developmental period, through a number of different mechanisms. Some of the very last events in neuronal development occur late in the postnatal period, when the mature set of synapses between neurons and their targets is selected and the adult anatomical and physiological properties of neurons are acquired. Experiments in many different systems have shown that the mature set of synapses is selected from an initial set by selective stabilization of some synapses and elimination of others (for review, see Purves and Lichtman 1985). The process of synapse selection is governed, at least in part, by neuronal activity. Temporal matching of pre-and postsynaptic activity is thought to be critical in determining whether a synapse will be retained or lost. Environmental stimuli (such...
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“A large number of animal studies have shown that PNNs are widely distributed in the brain”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Hockfield et al., 1990
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Lecticans: organizers of the brain extracellular matrix
Yamaguchi, Y. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000690 · Cited by 642
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Carulli, D., Pizzorusso, T., Kwok, J. C. F., Putignano, E., Poli, A., Forostyak, S., Andrews, M. R., Deepa, S. S., Glant, T. T., & Fawcett, J. W. (2010) · Brain · doi:10.1093/brain/awq145 · Cited by 495
“…CSPGs that were previously diffusely distributed are incorporated into specialized structures of condensed and stable matrix around the somata and dendrites of neurons, known as perineuronal nets (PNNs) (Hockfield et al.,1990; Schweizer et al., 1993; Pizzorusso et al., 2002; Galtrey et al., 2008).”
BackgroundExtracellular matrix of the central nervous system: from neglect to challenge
Zimmermann, D. R., & Dours-Zimmermann, M. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0485-9 · Cited by 465
“In addition, the establishment of perineuronal nets seems to stabilize the neuronal circuitry by suppressing the formation of new synaptic contacts (Galtrey and Fawcett 2007; HockWeld et al. 1990; Rauch 2004; Yamaguchi 2000).”
BackgroundExtracellular matrix and perineuronal nets in CNS repair
Kwok, J. C. F., Dick, G., Wang, D., & Fawcett, J. W. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20974 · Cited by 395
“Dark rearing in newborn cats prolongs the critical period in the visual cortex with a concomitant decrease in aggrecan immunostaining (Hockfield et al., 1990; Lander et al., 1997; Pizzurusso et al., 2002), but in developing chicks light deprivation did not prevent PNN formation (Gati et al.”
BackgroundInfluential
Metadata
- Authors
- Hockfield, S., Kalb, R. G., Zaremba, S., & Fryer, H.
- Affiliations
- Yale University (US)
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1990-01-01
- Volume
- 55
- Issue
- 0
- Pages
- 505-514
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2325060126
- Cited by
- 271
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 4 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 13 · 2013: 12 · 2012: 11
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08ns001247-04, 5f32ey005855-02)
- National Eye Institute (EY05855, EY 06511)
- National Institute of Neurological Disorders and Stroke (NS-01247)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- neuronal maturation, postnatal brain development, synaptic pruning, synaptic stabilization, central nervous system development
- MeSH terms
- Animals, Antibodies, Monoclonal, Brain, Cats, Cell Differentiation, Extracellular Matrix, Motor Neurons, Neurons, Chondroitin Sulfate Proteoglycans, Proteoglycans, Spinal Cord, Visual Cortex
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