Extracellular matrix of the central nervous system: from neglect to challenge

Zimmermann, Dieter R.; Dours-Zimmermann, María T.

doi:10.1007/s00418-008-0485-9

Cited by 466Proteoglycans and glycosaminoglycans researchNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

Extracellular matrix of the central nervous system: from neglect to challenge

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Zimmermann, Dieter R., Dours-Zimmermann, María T.·2008·Histochemistry and Cell Biology

DOI 10.1007/s00418-008-0485-9

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Abstract

The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal growth and thus, actively participate in the development and maturation of the nervous system, has in recent years gained rapidly expanding experimental support. The swift assembly and remodeling of these matrices have been associated with axonal guidance functions in the periphery and with the structural stabilization of myelinated fiber tracts and synaptic contacts in the maturating central nervous system. Particular interest has been focused on the putative role of chondroitin sulfate proteoglycans in suppressing central nervous system regeneration after lesions. The axon growth inhibitory properties of several of these chondroitin sulfate proteoglycans in vitro, and the partial recovery of structural plasticity in lesioned animals treated with chondroitin sulfate degrading enzymes in vivo have significantly contributed to the increased awareness of this long time neglected structure.

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During development, the ECM and CSPGs regulate neuronal migration, axon outgrowth, synaptogenesis and synaptic maturation.
“During development, the ECM, and CSPGs in particular, regulate neuronal migration, axon outgrowth, synaptogenesis and synaptic maturation.23, 27, 28, 29, 30, 31”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [29]
PNNs are mainly composed of hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins.
“The main components are hyaluronan (Figure 1), chondroitin sulfate proteoglycans (CSPGs) (i.e. aggrecan, brevican, neurocan, versican and phosphocan) (Figure 2), tenascins (Figure 3), and link proteins”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Zimmermann and Dours-Zimmermann, 2008
The perinodal net, a PNN-like structure, is commonly associated with the node of Ranvier.
“the perinodal-matrix or peridonal net, a PNN-like structure (Dours-Zimmermann et al., 2009; Zimmermann and Dours-Zimmermann, 2008), is commonly associated with the node of Ranvier”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Zimmermann and Dours-Zimmermann, 2008

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A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase β
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Chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of nervous tissue: developmental changes of neurocan and phosphacan
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Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures
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“are in vitro primarily astrocyte-derived (John et al. 2006), although perineuronal net-like structures develop apparently also in the virtual absence of glial cells (Miyata et al.”
Background
6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons
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Distribution and metabolism of glycoproteins and glycosaminoglycans in subcellular fractions of brain
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Versican V2 Is a Major Extracellular Matrix Component of the Mature Bovine Brain
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No Obvious Abnormality in Mice Deficient in Receptor Protein Tyrosine Phosphatase β
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Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets☆
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Human glioblastomas overexpress ADAMTS-5 that degrades brevican
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Isolation and Partial Characterization of a Glial Hyaluronate-binding Protein
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Adamts9 is widely expressed during mouse embryo development
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ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein
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The Fibrinogen-like Globe of Tenascin-C Mediates Its Interactions with Neurocan and Phosphacan/Protein-tyrosine Phosphatase-ζ/β
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Fetal Brain Extracellular Matrix Boosts Neuronal Network Formation in 3D Bioengineered Model of Cortical Brain Tissue
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Authors: Zimmermann, D. R., & Dours-Zimmermann, M. T.
Affiliations: University Hospital Zurich (CH)
Corresponding author: Zimmermann, Dieter R.
Venue: Histochemistry and Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-08-12
Volume: 130
Issue: 4
Pages: 635-653
ISSN: 0948-6143 (ISSN-L)
1432-119X
DOI: 10.1007/s00418-008-0485-9
OpenAlex: W2146369085
Cited by: 465
References: 240
Citations by year: 2026: 16 · 2025: 20 · 2024: 29 · 2023: 27 · 2022: 31 · 2021: 30 · 2020: 30 · 2019: 31 · 2018: 35 · 2017: 18 · 2016: 28 · 2015: 27 · 2014: 42 · 2013: 22 · 2012: 18
FWCI: 1.63
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/2.0 (tdm)
creativecommons.org/licenses/by-nc/2.0 (vor)
Locations: Histochemistry and Cell Biology (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
reroDoc Digital Library (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Funders: National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Universität Zürich
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: extracellular matrix, central nervous system, hyaluronic acid, chondroitin sulfate proteoglycans, aggrecan, versican, neurocan, brevican, phosphacan, tenascin, axon guidance, axon growth, myelination, synapse maturation, central nervous system regeneration, lesion recovery, structural plasticity
MeSH terms: Animals, Axons, Central Nervous System, Extracellular Matrix, Humans, Chondroitin Sulfate Proteoglycans

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Extracellular matrix of the central nervous system: from neglect to challenge

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