PreprintCited by 714DNA Repair MechanismsDNA and Nucleic Acid ChemistryCarcinogens and Genotoxicity Assessment

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Repair of Endogenous DNA Damage

LINDAHL, T., BARNES, D.E.·2000·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.2000.65.127

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Abstract

The remarkable stability of genes seemed a puzzlingfeature in the early days of molecular biology. It was evensuggested that new laws of physics might emerge to explain biological paradigms such as the resilience of thegenetic information. The complementary sequences inthe DNA double-helical structure provided a partial answer as to how this stability is retained, but it still tookmore than 10 years after the Watson and Crick 1953model to realize that radiation-damaged residues in DNAcould be corrected by a local excision-repair process. Inretrospect, the early concerns were fully justified; mammalian cellular DNA is a constant target of thermal"noise" in the form of spontaneous hydrolysis at 37ºC,and it is also susceptible to damage caused by active oxygen as well as reactive metabolites and coenzymes. Theresulting lesions are generally removed by the base excision repair (BER) pathway, resulting in short replacementpatches within one of the two DNA strands. Consequently, nonreplicating DNA is not absolutely stable butturns over at a relevant, albeit slow, rate in vivo. This endogenous repair is sufficiently accurate and efficient toexplain the apparent stability of the genetic material...

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Authors: LINDAHL, T., & BARNES, D. E.
ORCID: LINDAHL, T.
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 2000-01-01
Volume: 65
Issue: 0
Pages: 127-134
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.2000.65.127
OpenAlex: W2010677667
Cited by: 714
References: 60
Citations by year: 2026: 22 · 2025: 33 · 2024: 44 · 2023: 41 · 2022: 57 · 2021: 94 · 2020: 57 · 2019: 45 · 2018: 37 · 2017: 52 · 2016: 39 · 2015: 23 · 2014: 37 · 2013: 26 · 2012: 28
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (F31CA260794)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: DNA repair, endogenous DNA damage, base excision repair, spontaneous hydrolysis, reactive oxygen species, DNA stability, excision repair
MeSH terms: Animals, DNA, DNA Damage, DNA Repair, N-Glycosyl Hydrolases, Mice, Knockout, DNA-Formamidopyrimidine Glycosylase, DNA Glycosylases, Mice, Uracil-DNA Glycosidase

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Repair of Endogenous DNA Damage

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