Repair of Endogenous DNA Damage

Rate of depurination of native deoxyribonucleic acid

Lindahl, T. L., & Nyberg, B. (1972) · Biochemistry · doi:10.1021/bi00769a018 · Cited by 1,558

Quality Control by DNA Repair

Lindahl, T. L., & Wood, R. D. (1999) · Science · doi:10.1126/science.286.5446.1897 · Cited by 1,521

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

Bruner, S. D., Norman, D. P. G., & Verdine, G. L. (2000) · Nature · doi:10.1038/35002510 · Cited by 972

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

Klungland, A., Rosewell, I., Hollenbach, S., Larsen, E., Daly, G., Epe, B., Seeberg, E., Lindahl, T., & Barnes, D. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13300 · Cited by 807

Mutagenic deamination of cytosine residues in DNA

Duncan, B. K., & Miller, J. H. (1980) · Nature · doi:10.1038/287560a0 · Cited by 792

Second pathway for completion of human DNA base excision‐repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)

Klungland, A., & Lindahl, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3341 · Cited by 789

Reconstitution of DNA base excision‐repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

Kubota, Y., Nash, R. A., Klungland, A., Schär, P., Barnes, D. E., & Lindahl, T. L. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01056.x · Cited by 776

DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination

Mol, C. D., Izumi, T., MITRA, S. P., & Tainer, J. A. (2000) · Nature · doi:10.1038/35000249 · Cited by 764

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F., & Koonin, E. V. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.1.9034168 · Cited by 746

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368

Mechanisms of DNA damage, repair, and mutagenesis

Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039

Gene regulation and DNA damage in the ageing human brain

Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637

Endogenous DNA damage as a source of genomic instability in cancer

Tubbs, A., & Nussenzweig, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.002 · Cited by 1,452

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

Polo, S. E., & Jackson, S. P. (2011) · Genes & Development · doi:10.1101/gad.2021311 · Cited by 1,092

Role of oxidative stress and DNA damage in human carcinogenesis

Kryston, T. B., Georgiev, A. B., Pissis, P., & Georgakilas, A. G. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.016 · Cited by 952

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

Huang, R., & Zhou, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00648-7 · Cited by 1,015

Targeting DNA damage response pathways in cancer

Groelly, F. J., Fawkes, M., Dagg, R. A., Blackford, A. N., & Tarsounas, M. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00535-5 · Cited by 890

Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753

Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

Rada, C. A., Williams, G. T., Nilsen, H. L., Barnes, D. E., Lindahl, T. L., & Neuberger, M. S. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01215-0 · Cited by 712

ATM and ATR as therapeutic targets in cancer

Weber, A. M., & Ryan, A. J. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.001 · Cited by 676

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-08 · Cited by 591

A Genetic Map of the Response to DNA Damage in Human Cells

Olivieri, M., Cho, T., Álvarez-Quilón, A., Li, K., Schellenberg, M. J., Zimmermann, M., Hustedt, N., Rossi, S. E., Adam, S., Melo, H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.040 · Cited by 551

The cancer–natural killer cell immunity cycle

Huntington, N. D., Cursons, J., & Rautela, J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0272-z · Cited by 595

Chemotherapy Side-Effects: Not All DNA Damage Is Equal

van den Boogaard, W. M. C., Komninos, D. S. J., & Vermeij, W. P. (2022) · Cancers · doi:10.3390/cancers14030627 · Cited by 507

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

Reijns, M. A. M., Rabe, B., Rigby, R. E., Mill, P., Astell, K. R., Lettice, L. A., Boyle, S., Leitch, A., Keighren, M., Kilanowski, F., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.011 · Cited by 466

Base excision repair: A critical player in many games

Wallace, S. S. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.03.030 · Cited by 401

DNA repair mechanisms in cancer development and therapy

Torgovnick, A., & Schumacher, B. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00157 · Cited by 427

Redox Signaling by Reactive Electrophiles and Oxidants

Parvez, S., Long, M. J. C., Poganik, J. R., & Aye, Y. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00698 · Cited by 372

Assembly and function of DNA double-strand break repair foci in mammalian cells

Bekker-Jensen, S., & Mailand, N. (2010) · DNA Repair · doi:10.1016/j.dnarep.2010.09.010 · Cited by 338

Chromatin and nucleosome dynamics in DNA damage and repairPreprint

Hauer, M., & Gasser, S. M. (2017) · Genes & Development · doi:10.1101/gad.307702.117 · Cited by 320

8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification

Hahm, J. Y., Park, J., Jang, E.-S., & Chi, S. W. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00822-z · Cited by 359

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic ReticulumPreprint

Karagöz, G. E., Acosta‐Alvear, D., & Walter, P. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033886 · Cited by 306

Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine

van Loon, B., Markkanen, E., & Hübscher, U. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.03.004 · Cited by 321

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

O'Donovan, P. J., & Livingston, D. M. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq069 · Cited by 307

Functions of PARylation in DNA Damage Repair Pathways

Wei, H., & Yu, X. (2016) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.05.001 · Cited by 316

Cellular functions of the protein kinase ATM and their relevance to human disease

Lee, J., & Paull, T. T. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00394-2 · Cited by 303

DNA repair mechanisms in plants: crucial sensors and effectors for the maintenance of genome integrity

Bray, C. M., & West, C. E. (2005) · New Phytologist · doi:10.1111/j.1469-8137.2005.01548.x · Cited by 287

The circadian clock in cancer development and therapy

Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251

Activation of the ATR kinase by the RPA-binding protein ETAA1

Haahr, P., Hoffmann, S., Tollenaere, M. A. X., Ho, T., Toledo, L. I., Mann, M., Bekker‐Jensen, S., Räschle, M., & Mailand, N. (2016) · Nature Cell Biology · doi:10.1038/ncb3422 · Cited by 272

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases

Mertens, J., Reid, D. A., Lau, S., Kim, Y., & Gage, F. H. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031534 · Cited by 263

Translesion DNA polymerases in eukaryotes: what makes them tick?

Vaisman, A., & Woodgate, R. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1291576 · Cited by 261

DNA Damage: From Threat to Treatment

Carusillo, A., & Mussolino, C. (2020) · Cells · doi:10.3390/cells9071665 · Cited by 263

The role of poly ADP-ribosylation in the first wave of DNA damage response

Liu, C., Vyas, A., Kassab, M. A., Singh, A. K., & Yu, X. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx565 · Cited by 245

8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions

Ba, X., & Boldogh, I. R. (2017) · Redox Biology · doi:10.1016/j.redox.2017.11.008 · Cited by 255

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

Zierhut, C., & Diffley, J. F. X. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.111 · Cited by 234

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

Shanbhag, N. M., Evans, M. D., Mao, W., Nana, A. L., Seeley, W. W., Adame, A., Rissman, R. A., Masliah, E., & Mucke, L. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0723-5 · Cited by 214

5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription

Kellinger, M. W., Song, C., Chong, J. P. C., Lu, X., He, C., & Wang, D. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2346 · Cited by 235

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression

Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S., Hazra, T. K., Hegde, M. L., Radak, Z. O., Bácsi, A., Brasier, A. R., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.751453 · Cited by 203

Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil–DNA glycosylase

Nilsen, H. L., Haushalter, K. A., Robins, P., Barnes, D. E., Verdine, G. L., & Lindahl, T. L. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.4278 · Cited by 197

DNA Damage Response and Immune Defense: Links and Mechanisms

Nakad, R., & Schumacher, B. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00147 · Cited by 207

Cancer Drug Discovery and Development

Humphrey, J. S., Price, K., Gupta, E., Baxter, A. R. W., Bird, J., Sonnichsen, D. S., & Naglich, J. G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-325-5_21 · Cited by 195

Not breathing is not an option: How to deal with oxidative DNA damage

Markkanen, E. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.09.007 · Cited by 205

Comet assay: a versatile but complex tool in genotoxicity testing

Cordelli, E., Bignami, M., & Pacchierotti, F. (2021) · Toxicology Research · doi:10.1093/toxres/tfaa093 · Cited by 202

Clusters of Multiple Mutations: Incidence and Molecular Mechanisms

Chan, K., & Gordenin, D. A. (2015) · Annual Review of Genetics · doi:10.1146/annurev-genet-112414-054714 · Cited by 191

Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells

Berdelle, N., Nikolova, T., Quiros, S., Efferth, T., & Kaina, B. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0534 · Cited by 181

Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing

Maidarti, M., Anderson, R. A., & Telfer, E. E. (2020) · Cells · doi:10.3390/cells9010200 · Cited by 184

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model Organisms

Santos, A. L., Sinha, S., & Lindner, A. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1941285 · Cited by 168

DNA Repair and Genome Maintenance in Bacillus subtilis

Lenhart, J. S., Schroeder, J. W., Walsh, B. W., & Simmons, L. A. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05020-11 · Cited by 179

Autophagy in DNA Damage Response

Czarny, P. L., Pawłowska, E., Białkowska, J., Kaarniranta, K., & Błasiak, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16022641 · Cited by 166

Epigenetic drivers and genetic passengers on the road to cancer

Sawan, C., Vaissière, T., Murr, R., & Herceg, Z. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.03.002 · Cited by 178

Reactive oxygen species and DNA damage response in cancer

Renaudin, X. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.04.001 · Cited by 172

DNA replication fidelity and cancer

Preston, B. D., Albertson, T. M., & Herr, A. J. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.009 · Cited by 160

The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination

Zhao, W., Wiese, C., Kwon, Y., Hromas, R., & Sung, P. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111058 · Cited by 169

A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage

Zou, X., Koh, G. C. C., Nanda, A. S., Degasperi, A., Urgo, K., Roumeliotis, T. I., Agu, C. A., Badja, C., Momen, S., Young, J., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00200-0 · Cited by 164

The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline

Adewoye, A. B., Lindsay, S., Dubrova, Y. E., & Hurles, M. E. (2015) · Nature Communications · doi:10.1038/ncomms7684 · Cited by 155

Epigenetics, DNA damage, and aging

Soto-Palma, C., Niedernhofer, L. J., Faulk, C. D., & Dong, X. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158446 · Cited by 160

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks.

Poulsen, M., Lukas, C., Lukas, J., Bekker-Jensen, S., & Mailand, N. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201109100 · Cited by 146

SIRT6 in DNA repair, metabolism and ageing

Lombard, D. B., Schwer, B., Alt, F. W., & Mostoslavsky, R. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01902.x · Cited by 148

HELB Is a Feedback Inhibitor of DNA End Resection

Tkáč, J., Xu, G., Adhikary, H., Young, J. T. F., Gallo, D., Escribano‐Diaz, C., Krietsch, J., Orthwein, A., Munro, M., Sol, W., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.013 · Cited by 150

Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

Zámborszky, J., Szikriszt, B., Gervai, J. Z., Pipek, O., Póti, Á., Krzystanek, M., Ribli, D., Szalai-Gindl, J. M., Csabai, I., Szállási, Z., et al. (2016) · Oncogene · doi:10.1038/onc.2016.243 · Cited by 149

Base Excision Repair and its Role in Maintaining Genome Stability

Baute, J., & Depicker, A. (2008) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230802309905 · Cited by 140

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding zinc finger

Danielsen, J. R., Povlsen, L. K., Villumsen, B. H., Streicher, W., Nilsson, J., Wikström, M., Bekker-Jensen, S., & Mailand, N. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201106152 · Cited by 133

Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging

Gavia-García, G., Rosado-Pérez, J., Arista-Ugalde, T. L., Aguíñiga-Sánchez, I., Santiago‐Osorio, E., & Mendoza-Núñez, V. M. (2021) · Biology · doi:10.3390/biology10040253 · Cited by 148

Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions

Basourakos, S. P., Li, L., Aparicio, A. M., Corn, P. G., Kim, J., & Thompson, T. C. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666161214114948 · Cited by 136

DNA repair in mammalian embryos

Jaroudi, S., & SenGupta, S. B. (2006) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2006.09.002 · Cited by 131

Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

Shadfar, S., Parakh, S., Jamali, M. S., & Atkin, J. D. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00350-4 · Cited by 148

Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease

Welch, G., & Tsai, L. (2022) · The EMBO Reports · doi:10.15252/embr.202154217 · Cited by 129

The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment

Li, S., Wang, L., Wang, Y., Zhang, C., Hong, Z., & Han, Z. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01360-x · Cited by 141

Going beyond five bases in DNA sequencing

Korlach, J., & Turner, S. W. (2012) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2012.04.002 · Cited by 128

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

Ba, X., Aguilera-Aguirre, L., Rashid, Q. T. A., Bácsi, A., Radak, Z. O., Sur, S., Hosoki, K., Hegde, M. L., & Boldogh, I. R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916975 · Cited by 128

Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes

Tsutakawa, S. E., Shin, D. S., Mol, C. D., Izumi, T., Arvai, A. S., Mantha, A. K., Szczęsny, B., Ivanov, I. N., Hosfield, D. J., Maiti, B., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.422774 · Cited by 115

The capacity of oocytes for DNA repair

Stringer, J. M., Winship, A., Liew, S. H., & Hutt, K. J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2833-9 · Cited by 121

The Intra-S Checkpoint Responses to DNA Damage

Iyer, D., & Rhind, N. (2017) · Genes · doi:10.3390/genes8020074 · Cited by 131

DNA Repair Pathways and Mechanisms

Dexheimer, T. S. (2012) · Springer eBooks · doi:10.1007/978-94-007-4590-2_2 · Cited by 133

Synthetically Lethal Interactions of ATM, ATR, and DNA-PKcs

Kantidze, O. L., Velichko, A. K., Luzhin, A. V., Petrova, N. V., & Razin, S. V. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.09.007 · Cited by 112

Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA

Dunn, A. R., Kad, N. M., Nelson, S. R., Warshaw, D. M., & Wallace, S. S. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr459 · Cited by 118

Current Perspective in the Discovery of Anti-aging Agents from Natural Products

Ding, A., Zheng, S., Huang, X., Xing, T.-K., Wu, G.-S., Sun, H., Qi, S., & Luo, H. (2017) · Natural Products and Bioprospecting · doi:10.1007/s13659-017-0135-9 · Cited by 115

Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair

Nair, N., Shoaib, M., & Sørensen, C. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071486 · Cited by 117

Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

Andersen, S. B. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh347 · Cited by 114

Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation

Sakai, D., Dixon, J., Achilleos, A., Dixon, M. J., & Trainor, P. A. (2016) · Nature Communications · doi:10.1038/ncomms10328 · Cited by 117

Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis

Kalisperati, P., Spanou, E., Pateras, I. S., Korkolopoulou, P. A., Varvarigou, A. A., Karavokyros, I., Gorgoulis, V. G., Vlachoyiannopoulos, P. G., & Sougioultzis, S. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00020 · Cited by 115

Occupational pesticide exposure, impaired DNA repair, and diseases

Kaur, R., & Kaur, K. (2018) · Indian Journal of Occupational and Environmental Medicine · doi:10.4103/ijoem.ijoem_45_18 · Cited by 110

The Intertwined Roles of Transcription and Repair Proteins

Fong, Y. W., Cattoglio, C., & Tjian, R. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.018 · Cited by 106

The roles of base excision repair enzyme OGG1 in gene expression

Wang, R., Hao, W., Pan, L., Boldogh, I. R., & Ba, X. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2887-8 · Cited by 110

The ubiquitin‐ and SUMO‐dependent signaling response to DNA double‐strand breaks

Bekker‐Jensen, S., & Mailand, N. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.056 · Cited by 115

qDRIP: a method to quantitatively assess RNA–DNA hybrid formation genome-wide

Crossley, M. P., Bocek, M. J., Hamperl, S., Swigut, T., & Cimprich, K. A. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa500 · Cited by 102

The Structural Location of DNA Lesions in Nucleosome Core Particles Determines Accessibility by Base Excision Repair Enzymes

Rodriguez, Y., & Smerdon, M. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.441444 · Cited by 98

Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases

Nelson, S. R., Dunn, A. R., Kathe, S. D., Warshaw, D. M., & Wallace, S. S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400386111 · Cited by 97

A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation—and Beyond?

Schreiner, S., & Nassal, M. (2017) · Viruses · doi:10.3390/v9050125 · Cited by 105

OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos

Wang, R., Li, C., Qiao, P., Xue, Y., Zheng, X., Chen, H., Zeng, X., Liu, W., Boldogh, I. R., & Ba, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0680-0 · Cited by 101

DNA Break Mapping Reveals Topoisomerase II Activity Genome-Wide

Baranello, L., Kouzine, F., Wójtowicz, D., Cui, K., Przytycka, T. M., Zhao, K., & Levens, D. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150713111 · Cited by 92

Sirtuin 6: a review of biological effects and potential therapeutic properties

Beauharnois, J. M., Bolívar, B. E., & Welch, J. T. (2013) · Molecular BioSystems · doi:10.1039/c3mb00001j · Cited by 94

Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response

McCann, E., O'Sullivan, J. N., & Marcone, S. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100905 · Cited by 89

Chemical Insights into Oxidative and Nitrative Modifications of DNA

Andrés, C. M. C., de la Lastra, J. M. P., Andrés, C., Plou, F. J., & Pérez‐Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015240 · Cited by 96

Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability

Gorini, F., Scala, G., Cooke, M. S., Majello, B., & Amente, S. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.103027 · Cited by 96

Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens

Awwad, S. W., Serrano-Benítez, A., Thomas, J. C., Gupta, V., & Jackson, S. P. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00571-x · Cited by 93

Direct Detection and Sequencing of Damaged DNA Bases

Clark, T. A., Spittle, K. E., Turner, S. W., & Korlach, J. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-10 · Cited by 88

Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753

The Croonian Lecture, 1996: Endogenous damage to DNA

Lindahl, T. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0139 · Cited by 100

Suppression of spontaneous mutagenesis in human cells by DNA base excision–repair

Lindahl, T. L. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00024-7 · Cited by 214

Why Is DNA Double Stranded? The Discovery of DNA Excision Repair Mechanisms

Strauss, B. S. (2018) · Genetics · doi:10.1534/genetics.118.300958 · Cited by 13

Repair Enzyme suggested by Mammalian Endonuclease Activity specific for Ultraviolet-irradiated DNA

Brent, T. P. (1972) · Nature New Biology · doi:10.1038/newbio239172a0 · Cited by 51