The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Repair of Endogenous DNA Damage
Abstract
The remarkable stability of genes seemed a puzzlingfeature in the early days of molecular biology. It was evensuggested that new laws of physics might emerge to explain biological paradigms such as the resilience of thegenetic information. The complementary sequences inthe DNA double-helical structure provided a partial answer as to how this stability is retained, but it still tookmore than 10 years after the Watson and Crick 1953model to realize that radiation-damaged residues in DNAcould be corrected by a local excision-repair process. Inretrospect, the early concerns were fully justified; mammalian cellular DNA is a constant target of thermal"noise" in the form of spontaneous hydrolysis at 37ºC,and it is also susceptible to damage caused by active oxygen as well as reactive metabolites and coenzymes. Theresulting lesions are generally removed by the base excision repair (BER) pathway, resulting in short replacementpatches within one of the two DNA strands. Consequently, nonreplicating DNA is not absolutely stable butturns over at a relevant, albeit slow, rate in vivo. This endogenous repair is sufficiently accurate and efficient toexplain the apparent stability of the genetic material...
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“the majority ultimately manifest in the form of single‐strand breaks (SSBs)”
From Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease (2022) · cites this paper as Lindahl & Barnes, 2000
In the citing paper
“reactive oxygen species (ROS), which attack DNA to form oxidized bases and abasic sites”
From Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease (2022) · cites this paper as Lindahl & Barnes, 2000
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Cites
1 retracted
Cooper, P. K., Nouspikel, T. P., Clarkson, S. G., & Leadon, S. A. (1997) · Science · doi:10.1126/science.275.5302.990 · Cited by 306
RetractedRate of depurination of native deoxyribonucleic acid
Lindahl, T. L., & Nyberg, B. (1972) · Biochemistry · doi:10.1021/bi00769a018 · Cited by 1,558
Self-citationLindahl, T. L., & Wood, R. D. (1999) · Science · doi:10.1126/science.286.5446.1897 · Cited by 1,521
Self-citationStructural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
Bruner, S. D., Norman, D. P. G., & Verdine, G. L. (2000) · Nature · doi:10.1038/35002510 · Cited by 972
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
Klungland, A., Rosewell, I., Hollenbach, S., Larsen, E., Daly, G., Epe, B., Seeberg, E., Lindahl, T., & Barnes, D. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13300 · Cited by 807
Self-citationMutagenic deamination of cytosine residues in DNA
Duncan, B. K., & Miller, J. H. (1980) · Nature · doi:10.1038/287560a0 · Cited by 792
Klungland, A., & Lindahl, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3341 · Cited by 789
Self-citationKubota, Y., Nash, R. A., Klungland, A., Schär, P., Barnes, D. E., & Lindahl, T. L. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01056.x · Cited by 776
Self-citationDNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination
Mol, C. D., Izumi, T., MITRA, S. P., & Tainer, J. A. (2000) · Nature · doi:10.1038/35000249 · Cited by 764
A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins
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- Nakamura J., 1998, Cancer Res., 58, 222
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The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368
Mechanisms of DNA damage, repair, and mutagenesis
Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039
Gene regulation and DNA damage in the ageing human brain
Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637
Metadata
- Authors
- LINDAHL, T., & BARNES, D. E.
- ORCID
- LINDAHL, T.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-01-01
- Volume
- 65
- Issue
- 0
- Pages
- 127-134
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2010677667
- Cited by
- 714
- References
- 60
- Citations by year
- 2026: 22 · 2025: 33 · 2024: 44 · 2023: 41 · 2022: 57 · 2021: 94 · 2020: 57 · 2019: 45 · 2018: 37 · 2017: 52 · 2016: 39 · 2015: 23 · 2014: 37 · 2013: 26 · 2012: 28
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (F31CA260794)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- DNA repair, endogenous DNA damage, base excision repair, spontaneous hydrolysis, reactive oxygen species, DNA stability, excision repair
- MeSH terms
- Animals, DNA, DNA Damage, DNA Repair, N-Glycosyl Hydrolases, Mice, Knockout, DNA-Formamidopyrimidine Glycosylase, DNA Glycosylases, Mice, Uracil-DNA Glycosidase
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