The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Contractile Units in Disordered Actomyosin Bundles Arise from F-Actin Buckling
Open accessAbstract
Bundles of filaments and motors are central to contractility in cells. The classic example is striated muscle, where actomyosin contractility is mediated by highly organized sarcomeres which act as fundamental contractile units. However, many contractile bundles in vivo and in vitro lack sarcomeric organization. Here we propose a model for how contractility can arise in bundles without sarcomeric organization and validate its predictions with experiments on a reconstituted system. In the model, internal stresses in frustrated arrangements of motors with diverse velocities cause filaments to buckle, leading to overall shortening. We describe the onset of buckling in the presence of stochastic motor head detachment and predict that buckling-induced contraction occurs in an intermediate range of motor densities. We then calculate the size of the "contractile units" associated with this process. Consistent with these results, our reconstituted actomyosin bundles show contraction at relatively high motor density, and we observe buckling at the predicted length scale.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Stress filaments consist of actin, myosin-II dimers, and associated crosslinkers.
“Stress filaments consist of actin, myosin-II dimers, and associated crosslinkers (Fig. 3c) [32–34].”
From Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis (2026) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Asters, Vortices, and Rotating Spirals in Active Gels of Polar Filaments
Kruse, K., Joanny, J., Jülicher, F., Prost, J., & Sekimoto, K. (2004) · Physical Review Letters · doi:10.1103/physrevlett.92.078101 · Cited by 583
Generic theory of active polar gels: a paradigm for cytoskeletal dynamics
Kruse, K., Joanny, J., Jülicher, F., et al. (2005) · The European Physical Journal E · doi:10.1140/epje/e2005-00002-5 · Cited by 537
Mechanics of the F-actin cytoskeleton
Stricker, J., Falzone, T. T., & Gardel, M. L. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.003 · Cited by 472
Self-citationStiff Chains and Filaments under Tension
Odijk, T. (1995) · Macromolecules · doi:10.1021/ma00124a044 · Cited by 457
Cramer, L. P., Siebert, M. C., & Mitchison, T. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.6.1287 · Cited by 317
Active multistage coarsening of actin networks driven by myosin motors
Silva, M. S. E., Depken, M., Stuhrmann, B., Korsten, M., MacKintosh, F. C., & Koenderink, G. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016616108 · Cited by 227
Instabilities of Isotropic Solutions of Active Polar Filaments
Liverpool, T. B., & Marchetti, M. C. (2003) · Physical Review Letters · doi:10.1103/physrevlett.90.138102 · Cited by 215
Structural Memory in the Contractile Ring Makes the Duration of Cytokinesis Independent of Cell Size
Carvalho, A. X., Desai, A. B., & Oegema, K. (2009) · Cell · doi:10.1016/j.cell.2009.03.021 · Cited by 206
Nonequilibrium Mechanics and Dynamics of Motor-Activated Gels
MacKintosh, F. C., & Levine, A. J. (2008) · Physical Review Letters · doi:10.1103/physrevlett.100.018104 · Cited by 203
Actively Contracting Bundles of Polar Filaments
Kruse, K., & Jülicher, F. (2000) · Physical Review Letters · doi:10.1103/physrevlett.85.1778 · Cited by 186
Reconstitution of Contractile Actomyosin Bundles
Thoresen, T., Lenz, M., & Gardel, M. L. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.04.031 · Cited by 137
Self-citationPolarity and Velocity of Sliding Filaments: Control of Direction by Actin and of Speed by Myosin
Sellers, J. R., & Kachar, B. (1990) · Science · doi:10.1126/science.2377894 · Cited by 122
`Sarcomeres' of smooth muscle: functional characteristics and ultrastructural evidence
Herrera, A. M., McParland, B. E., Bienkowska, A., Tait, R., Paré, P. D., & Seow, C. Y. (2005) · Journal of Cell Science · doi:10.1242/jcs.02368 · Cited by 121
Shape oscillations of non-adhering fibroblast cells
Salbreux, G., Joanny, J., Prost, J., & Pullarkat, P. A. (2007) · Physical Biology · doi:10.1088/1478-3975/4/4/004 · Cited by 115
Distribution of alpha-actinin in single isolated smooth muscle cells
Fay, F. S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.3.783 · Cited by 96
Self-organization and mechanical properties of active filament bundles
Kruse, K., & Jülicher, F. (2003) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.67.051913 · Cited by 94
Requirements for contractility in disordered cytoskeletal bundles
Lenz, M., Gardel, M. L., & Dinner, A. R. (2012) · New Journal of Physics · doi:10.1088/1367-2630/14/3/033037 · Cited by 70
Self-citationAttachment Conditions Control Actin Filament Buckling and the Production of Forces
Berro, J., Michelot, A., Blanchoin, L., et al. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.094672 · Cited by 61
Mechanical response of active gels
Liverpool, T. B., Marchetti, M. C., Joanny, J., et al. (2009) · Europhysics Letters (EPL) · doi:10.1209/0295-5075/85/18007 · Cited by 56
Motor-induced sliding of microtubule and actin bundles
Zemel, A., & Mogilner, A. (2009) · Physical Chemistry Chemical Physics · doi:10.1039/b818482h · Cited by 46
Super helix formation of actin filaments in an in vitro motile system
Tanaka, Y., Ishijima, A., & Ishiwata, S. (1992) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(92)90079-s · Cited by 43
Bement, W. M., & Capco, D. G. (1991) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970200207 · Cited by 42
Yamada, A., Ishii, N., & Takahashi, K. (1990) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123203 · Cited by 41
Epidermal growth factor receptor and ligands in elongating bovine blastocysts
Kliem, A., Tetens, F., Klonisch, T. C., Grealy, M., & Fischer, B. (1998) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199812)51:4 · Cited by 41
Continuum theory of contractile fibres
Kruse, K., Zumdieck, A., & Jülicher, F. (2003) · Europhysics Letters (EPL) · doi:10.1209/epl/i2003-00618-2 · Cited by 40
Growth of fingerlike protrusions driven by molecular motors
Kruse, K., & Sekimoto, K. (2002) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.66.031904 · Cited by 39
Gilboa, B., Gillo, D., Farago, O., & Bernheim‐Groswasser, A. (2009) · Soft Matter · doi:10.1039/b823400k · Cited by 23
Polarity Patterns of Stress Fibers
Yoshinaga, N., Joanny, J., Prost, J., et al. (2010) · Physical Review Letters · doi:10.1103/physrevlett.105.238103 · Cited by 20
Pattern formation in active cytoskeletal networks
Peter, R., Schaller, V., Ziebert, F., et al. (2008) · New Journal of Physics · doi:10.1088/1367-2630/10/3/035002 · Cited by 15
Cooperative molecular motors moving back and forth
Gillo, D., Gur, B., Bernheim‐Groswasser, A., et al. (2009) · Physical Review E · doi:10.1103/physreve.80.021929 · Cited by 9
Flagged first, then by citations
Research works printed but not linked: 1
- B. Alberts, 1998, Essential Cell Biology
Cited by
Sorted by citations
Broßell, D., Meyer-Plath, A., Gräb, O., Heunisch, E., Kämpf, K., Haase, A., & Wiemann, M. (2026) · Particle and Fibre Toxicology · doi:10.1186/s12989-026-00666-9 · Cited by 2
Metadata
- Authors
- Lenz, M., Thoresen, T., Gardel, M. L., & Dinner, A. R.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Dinner, Aaron R.
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 2012-06-08
- Volume
- 108
- Issue
- 23
- Pages
- 238107-238107
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- PMC
- PMC4447086
- OpenAlex
- W2057427321
- Cited by
- 153
- References
- 30
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 3 · 2023: 4 · 2022: 14 · 2021: 9 · 2020: 5 · 2019: 13 · 2018: 21 · 2017: 17 · 2016: 13 · 2015: 9 · 2014: 12 · 2013: 12 · 2012: 3
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Physical Review Letters (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Funders
- National Science Foundation
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- filament buckling, traffic density, contractility
- MeSH terms
- Actins, Actomyosin, Actin Cytoskeleton, Models, Biological, Muscle Contraction, Muscle, Striated
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
