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Gaussian Dynamics of Folded Proteins
Abstract
Vibrational dynamics of folded proteins is studied using a Gaussian model in which the protein is viewed as a network, residues representing the junctions, and the connectivity being established by a single parameter harmonic potential. Application to seven proteins showed that the local packing density plays a major role in determining the vibrational spectrum at time scales of picoseconds. At later times, the secondary structure and tertiary context of each residue comes into play. The vibrational frequencies obey a universal distribution, confirming previous normal mode analyses.
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Citations
Cited by
Dynamic personalities of proteins
Henzler-Wildman, K., & Kern, D. (2007) · Nature · doi:10.1038/nature06522 · Cited by 2,545
Global dynamics of proteins: bridging between structure and function
Bahar, I., Lezon, T. R., Yang, L.-W., & Eyal, E. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.093008.131258 · Cited by 610
Self-citationYang, L.-W., & Bahar, I. (2005) · Structure · doi:10.1016/j.str.2005.03.015 · Cited by 273
Self-citationControlling Allosteric Networks in Proteins
Dokholyan, N. V. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00544 · Cited by 260
Protein elastic network models and the ranges of cooperativity
Yang, L., Song, G., & Jernigan, R. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902159106 · Cited by 260
Metadata
- Authors
- Haliloglu, T., Bahar, I., & Erman, B.
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 1997-10-20
- Volume
- 79
- Issue
- 16
- Pages
- 3090-3093
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- OpenAlex
- W2108700551
- Cited by
- 772
- References
- 0
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haliloglu, T., Bahar, I., & Erman, B. (1997). Gaussian Dynamics of Folded Proteins. Physical Review Letters. https://doi.org/10.1103/physrevlett.79.3090
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