Phase Diagrams of Quasispecies Theory with Recombination and Horizontal Gene Transfer.
Open accessAbstract
We consider how transfer of genetic information between individuals influences the phase diagram and mean fitness of both the Eigen and the parallel, or Crow-Kimura, models of evolution. In the absence of genetic transfer, these physical models of evolution consider the replication and point mutation of the genomes of independent individuals in a large population. A phase transition occurs, such that below a critical mutation rate an identifiable quasispecies forms. We show how transfer of genetic information changes the phase diagram and mean fitness and introduces metastability in quasispecies theory, via an analytic field theoretic mapping.
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A rigorous consideration of the single peak fitness landscape with the simplest version of recombination in [49] proves that recombination does not change the mean fitness error threshold for the long genome and hence could not solve the error paradox.
“A rigorous consideration of the single peak fitness landscape with the simplest version of recombination in [49] proves that the recombination does not change the (mean fitness) error threshold for the long genome and hence could not solve the error paradox.”
From Lethal mutants and truncated selection together solve a paradox of the origin of life (2011) · cites this paper as [49]
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- Authors
- Park, J.-M., & Deem, M. W.
- Affiliations
- Rice University (US)
- ORCID
- Deem, M. W.
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 2007-01-29
- Volume
- 98
- Issue
- 5
- Pages
- 058101-058101
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- OpenAlex
- W2078219342
- Cited by
- 69
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 8 · 2014: 5 · 2013: 4 · 2012: 4
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- green
- arxiv.org
- Locations
- Physical Review Letters (publishedVersion)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Mathematics › Mathematical Physics › Stochastic processes and statistical mechanics
- Physical Sciences › Physics and Astronomy › Condensed Matter Physics › Theoretical and Computational Physics
- Keywords
- quasispecies theory, phase diagram, horizontal gene transfer, recombination, Eigen model, mean fitness, phase transitions, metastability
- MeSH terms
- Biophysics, Biological Evolution, Models, Genetic, Mutation, Recombination, Genetic, Models, Statistical, Gene Transfer, Horizontal, Biophysical Phenomena
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