A constant rate of spontaneous mutation in DNA-based microbes.

Drake, J W

doi:10.1073/pnas.88.16.7160

Cited by 1,199Evolution and Genetic DynamicsRNA and protein synthesis mechanismsGenomics and Phylogenetic Studies

A constant rate of spontaneous mutation in DNA-based microbes.

Open access

Drake, J W·1991·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.88.16.7160PMC PMC52253

Open this paper in CoChat — free account

Abstract

In terms of evolution and fitness, the most significant spontaneous mutation rate is likely to be that for the entire genome (or its nonfrivolous fraction). Information is now available to calculate this rate for several DNA-based haploid microbes, including bacteriophages with single- or double-stranded DNA, a bacterium, a yeast, and a filamentous fungus. Their genome sizes vary by approximately 6500-fold. Their average mutation rates per base pair vary by approximately 16,000-fold, whereas their mutation rates per genome vary by only approximately 2.5-fold, apparently randomly, around a mean value of 0.0033 per DNA replication. The average mutation rate per base pair is inversely proportional to genome size. Therefore, a nearly invariant microbial mutation rate appears to have evolved. Because this rate is uniform in such diverse organisms, it is likely to be determined by deep general forces, perhaps by a balance between the usually deleterious effects of mutation and the physiological costs of further reducing mutation rates.

Integrity signals

Registry

Crossref · 10.1073/pnas.88.16.7160

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Increased tolerance of S. cerevisiae towards lignocellulosic hydrolysates such as acetic acid and furfural was correlated with adaptive changes of the oxidative stress response.
“Increased tolerance of S. cerevisiae towards lignocellulosic hydrolysates such as acetic acid and furfural was correlated with adaptive changes of the oxidative stress response [112].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [112]
Cross-protection towards lignocellulosic hydrolysates can be evolved in S. cerevisiae; several mutants showed increased fitness in the presence of inhibitor combinations but reduced fitness when exposed to individual hydrolysate components.
“A recent study showed that cross-protection towards lignocellulosic hydrolysates can be evolved in S. cerevisiae. Interestingly, several mutants showed increased fitness in the presence of inhibitor combinations but reduced fitness when exposed to individual hydrolysate components [112].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [112]

Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology
Neidhardt, F. C., & Ingraham, J. L. (1987) · Medical Entomology and Zoology · Cited by 4,089 · see citing works
Mutations of bacteria from virus sensitivity to virus resistance
Luria, S. E., & Delbrück, M. (1943) · Genetics · doi:10.1093/genetics/28.6.491 · Cited by 3,894 · see citing works
Outliers in Statistical Data
BARNETT, V. D., Lewis, T., & Abeles, F. F. (1979) · Physics Today · doi:10.1063/1.2995737 · Cited by 2,834 · see citing works
Chemical Mutagens. Principles and Methods for Their Detection.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-439_4 · Cited by 1,456 · see citing works
Nucleotide sequence of bacteriophage λ DNA
Sanger, F., Coulson, A. R., Hong, G. F., Hill, D. F., & Petersen, G. B. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90546-0 · Cited by 1,174 · see citing works
The origin of mutants
Cairns, J., Overbaugh, J., & Miller, S. (1988) · Nature · doi:10.1038/335142a0 · Cited by 1,025 · see citing works
Evolution in bacteria: Evidence for a universal substitution rate in cellular genomes
Ochman, H., & Wilson, A. C. (1987) · Journal of Molecular Evolution · doi:10.1007/bf02111283 · Cited by 780 · see citing works
Sequence of the lacI gene
Farabaugh, P. J. (1978) · Nature · doi:10.1038/274765a0 · Cited by 457 · see citing works
Nucleotide sequence of the filamentous bacteriophage M13 DNA genome: comparison with phage fd
van Wezenbeek, P. M. G. F., Hulsebos, T. J. M., & Schoenmakers, J. G. G. (1980) · Gene · doi:10.1016/0378-1119(80)90093-1 · Cited by 411 · see citing works
A Physical Map of the Escherichia coli K12 Genome
Smith, C. L., Econome, J. G., Schutt, A. D., et al. (1987) · Science · doi:10.1126/science.3296194 · Cited by 401 · see citing works
The Adaptive Responses of Escherichia coli to a Feast and Famine Existence
Koch, A. L. (1971) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60069-7 · Cited by 393 · see citing works
Spontaneous point mutations that occur more often when advantageous than when neutral.
Hall, B. G. (1990) · Genetics · doi:10.1093/genetics/126.1.5 · Cited by 326 · see citing works
The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations.
Kunkel, T. A. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89090-1 · Cited by 316 · see citing works
THE MOLECULAR BASIS OF MUTATION
Drake, J. W., & Flamm, W. G. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-677950-9.50008-8 · Cited by 313 · see citing works
Self-citation
Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene
Schaaper, R. M., Danforth, B. N., & Glickman, B. W. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90509-7 · Cited by 306 · see citing works
Structure and function of the yeast URA3 gene: expression in Escherichia coli
Rose, M. D., Grisafi, P. L., & Botstein, D. (1984) · Gene · doi:10.1016/0378-1119(84)90172-0 · Cited by 302 · see citing works
The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation.
Kunkel, T. A., & Alexander, P. S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42446-x · Cited by 299 · see citing works
An Electrophoretic Karyotype of Neurospora crassa
Orbach, M. J., Vollrath, D., Davis, R. W., & Yanofsky, C. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.4.1469 · Cited by 279 · see citing works
Genetic map of Saccharomyces cerevisiae , edition 10
Mortimer, R., Schild, D., Contopoulou, C. R., et al. (1989) · Yeast · doi:10.1002/yea.320050503 · Cited by 277 · see citing works
Yeast ribosomal DNA genes are located on chromosome XII.
Petes, T. D. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.410 · Cited by 244 · see citing works
Frequency of fixation of adaptive mutations is higher in evolving diploid than haploid yeast populations
Paquin, C., & Adams, J. (1983) · Nature · doi:10.1038/302495a0 · Cited by 239 · see citing works
Spontaneous Mutation: Genetic Control of Mutation Rates in Bacteriophage T4
Drake, J. W., Allen, E. F., Forsberg, S. A., Preparata, R.-M., & Greening, E. O. (1969) · Nature · doi:10.1038/2211128a0 · Cited by 206 · see citing works
Self-citation
Classification and Mapping of Spontaneous and Induced Mutations in The Histidine Operon of Salmonella
Hartman, P. E., Hartman, Z., Stahl, R. C., et al. (1971) · Advances in genetics · doi:10.1016/s0065-2660(08)60352-1 · Cited by 201 · see citing works
Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence.
Hoffmann, W. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39106-8 · Cited by 162 · see citing works
rII cistrons of bacteriophage T4
Pribnow, D. G., Sigurdson, D. C., Gold, L., et al. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90477-0 · Cited by 157 · see citing works
THE CAN1 LOCUS OF SACCHAROMYCES CEREVISIAE: FINE-STRUCTURE ANALYSIS AND FORWARD MUTATION RATES
Whelan, W. L., Gocke, E., & Manney, T. R. (1979) · Genetics · doi:10.1093/genetics/91.1.35 · Cited by 156 · see citing works
Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons
Carlomagno, M. S., Chiariotti, L., Alifano, P., Nappo, A. G., & Bruni, C. B. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90194-5 · Cited by 151 · see citing works
Electron microscope heteroduplex study of sequence relations of T2, T4, and T6 bacteriophage DNAs
Kim, J.-S., & Davidson, N. (1974) · Virology · doi:10.1016/0042-6822(74)90111-1 · Cited by 149 · see citing works
THE FREQUENCY DISTRIBUTION OF SPONTANEOUS BACTERIOPHAGE MUTANTS AS EVIDENCE FOR THE EXPONENTIAL RATE OF PHAGE REPRODUCTIONPreprint
Luria, S. E. (1951) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1951.016.01.033 · Cited by 126 · see citing works
DNA sequence of the bacteriophage λ cI gene
Sauer, R. T. (1978) · Nature · doi:10.1038/276301a0 · Cited by 120 · see citing works
Yeast arginine permease: nucleotide sequence of the CAN1 gene
Ahmad, M., & Bussey, H. (1986) · Current Genetics · doi:10.1007/bf00418125 · Cited by 93 · see citing works
Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and characterization of the CDC24 gene and adjacent regions of the chromosome.
Coleman, K. G., Steensma, H. Y., Kaback, D. B., & Pringle, J. R. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.12.4516 · Cited by 74 · see citing works
Changes in DNA base sequence induced by gamma-ray mutagenesis of lambda phage and prophage.
Tindall, K. R., Stein, J., & Hutchinson, F. (1988) · Genetics · doi:10.1093/genetics/118.4.551 · Cited by 69 · see citing works
Mutagenic action during meiosis and antimutagenic action during mitosis by 5-aminoacridine in yeast
Magni, G. E., von Borstel, R. C., & Sora, S. (1964) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(64)90003-x · Cited by 65 · see citing works
The base-alteration spectrum of spontaneous and ultraviolet radiation-induced forward mutations in the URA3 locus of Saccharomyces cerevisiae
Lee, G. S. F., Savage, E. A., Ritzel, R. G., & von Borstel, R. C. (1988) · Molecular and General Genetics MGG · doi:10.1007/bf00330472 · Cited by 65 · see citing works
DNA base sequence changes induced by bromouracil mutagenesis of lambda phage
Skopek, T. R., & Hutchinson, F. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90029-8 · Cited by 65 · see citing works
An Electrophoretic Karyotype of Neurospora crassa
Orbach, M. J., Vollrath, D., Davis, R. W., et al. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.4.1469-1473.1988 · Cited by 64 · see citing works
A fine structure map of spontaneous and induced mutations in the lambda repressor gene, including insertions of IS elements
Lieb, M. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00352506 · Cited by 62 · see citing works
The 52-protein subunit of T4 DNA topoisomerase is homologous to the gyrA-protein of gyrase.
Huang, W. M. (1986) · PubMed · Cited by 50 · see citing works
Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and analysis of the CEN1-ADE1-CDC15 region.
Steensma, H. Y., Crowley, J. C., & Kaback, D. B. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.1.410 · Cited by 48 · see citing works
Specificity of the mutator effect caused by disruption of the RAD1 excision repair gene of Saccharomyces cerevisiae
Kunz, B. A., Kohalmi, L., Kang, X. L., & Magnusson, K. A. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.6.3009-3014.1990 · Cited by 44 · see citing works
Mutagenic effects of thymine dimers in bacteriophage T4
Meistrich, M. L., & Drake, J. W. (1972) · Journal of Molecular Biology · doi:10.1016/s0022-2836(72)80009-3 · Cited by 43 · see citing works
Self-citation
Ultraviolet Mutagenesis in Bacteriophage T4 I. Irradiation of Extracellular Phage Particles
Drake, J. W. (1966) · Journal of Bacteriology · doi:10.1128/jb.91.5.1775-1780.1966 · Cited by 43 · see citing works
Self-citation
Mutagen specificity and position effects on mutation in T4rII nonsense sites
Ronen, A., & Rahat, A. (1976) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(76)90258-x · Cited by 43 · see citing works
Analysis of yeast retrotransposon Ty insertions at the CAN1 locus.
Wilke, C. M., Heidler, S., Brown, N., et al. (1989) · Genetics · doi:10.1093/genetics/123.4.655 · Cited by 42 · see citing works
Forward and reverse mutation in a histidine-requiring strain of Escherichia coli.
Lieb, M. (1951) · Genetics · doi:10.1093/genetics/36.5.460 · Cited by 31 · see citing works
Sequences and studies of bacteriophage T4 rII mutants
Shinedling, S. T., Singer, B. S., Gayle, M. A., et al. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90176-8 · Cited by 28 · see citing works
Sequence and structure of mtr, an amino acid transport gene of Neurospora crassa
Koo, K., & Stuart, W. D. (1991) · Genome · doi:10.1139/g91-098 · Cited by 28 · see citing works
Ultraviolet Mutagenesis in Bacteriophage T4 II. Photoreversal of Mutational Lesions
Drake, J. W. (1966) · Journal of Bacteriology · doi:10.1128/jb.92.1.144-147.1966 · Cited by 22 · see citing works
Self-citation
[Defective lysogenic bacteria. II. Physiological types resulting from prophage mutations].
Jacob, F., Fuerst, R. G., & El, W. (1957) · PubMed · Cited by 22 · see citing works
Molecular Cloning of Chromosome I DNA from Saccharomyces cerevisiae: Isolation and Characterization of the CDC24 Gene and Adjacent Regions of the Chromosome
Coleman, K. G., Steensma, H. Y., Kaback, D. B., & Pringle, J. R. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.12.4516-4525.1986 · Cited by 19 · see citing works
MUTATORS IN SACCHAROMYCES CEREVISIAE: MUT1–1, MUT1–2 AND MUT2–1
Gottlieb, D. J. C., & von Borstel, R. C. (1976) · Genetics · doi:10.1093/genetics/83.4.655 · Cited by 17 · see citing works
Modulation of mutation rates in bacteriophage T4 by a base-pair change a dozen nucleotides removed
Sugino, A., & Drake, J. W. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90422-4 · Cited by 17 · see citing works
Self-citation
CRYPTIC MUTANTS OF BACTERIOPHAGE T4
Koch, R. E., & Drake, J. W. (1970) · Genetics · doi:10.1093/genetics/65.3.379 · Cited by 17 · see citing works
Self-citation
Molecular Cloning of Chromosome I DNA from Saccharomyces cerevisiae: Isolation and Analysis OF THE CEN1-ADE1-CDC15 Region
Steensma, H. Y., Crowley, J. C., & Kaback, D. B. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.1.410-419.1987 · Cited by 15 · see citing works
The rIIA gene of bacteriophage T4. I. Its DNA sequence and discovery of a new open reading frame between genes 60 and rIIA.
Daegelen, P., & Brody, E. N. (1990) · Genetics · doi:10.1093/genetics/125.2.237 · Cited by 10 · see citing works

Flagged first, then by citations

Sorted by citations

Rates of spontaneous mutation
Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932 · see citing works
Self-citation
Genome evolution and adaptation in a long-term experiment with Escherichia coli
Barrick, J. E., Yu, D. S., Yoon, S. H., Jeong, H., Oh, T. K., Schneider, D., Lenski, R. E., & Kim, J. F. (2009) · Nature · doi:10.1038/nature08480 · Cited by 1,184 · see citing works
Mutation rates among RNA viruses
Drake, J. W., & Holland, J. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13910 · Cited by 1,143 · see citing works
Self-citation
Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli
Blount, Z. D., Borland, C. Z., & Lenski, R. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803151105 · Cited by 840 · see citing works
Adaptive laboratory evolution—Principles and applications for biotechnology
Dragosits, M., & Mattanovich, D. (2013) · Microbial Cell Factories · doi:10.1186/1475-2859-12-64 · Cited by 827 · see citing works
DNA Replication Fidelity
Kunkel, T. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400006200 · Cited by 754 · see citing works
Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing
Lee, H., Popodi, E., Tang, H., & Foster, P. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210309109 · Cited by 681 · see citing works
Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance
Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-08 · Cited by 591 · see citing works
Long-term survival during stationary phase: evolution and the GASP phenotype
Finkel, S. E. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1340 · Cited by 508 · see citing works
Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptation
Moxon, R., Bayliss, C., & Hood, D. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090442 · Cited by 438 · see citing works
The emergence of antibiotic resistance by mutation
Woodford, N., & Ellington, M. J. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01492.x · Cited by 417 · see citing works
Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant
Levy, S. F., Ziv, N., & Siegal, M. L. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001325 · Cited by 371 · see citing works
Estimating the Per-Base-Pair Mutation Rate in the Yeast Saccharomyces cerevisiae
Lang, G. I., & Murray, A. W. (2008) · Genetics · doi:10.1534/genetics.107.071506 · Cited by 344 · see citing works
Methods for determining spontaneous mutation rates
Foster, P. L. (2006) · Methods in Enzymology · doi:10.1016/s0076-6879(05)09012-9 · Cited by 302 · see citing works
Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.
Schaaper, R. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80446-3 · Cited by 305 · see citing works
Stress Alters Rates and Types of Loss of Heterozygosity in Candida albicans
Forche, A., Abbey, D., Pisithkul, T., Weinzierl, M. A., Ringstrom, T., Bruck, D., Petersen, K., & Berman, J. (2011) · mBio · doi:10.1128/mbio.00129-11 · Cited by 234 · see citing works
Evolutionary and Population Genomics of the Cavity Causing Bacteria Streptococcus mutans
Cornejo, O. E., Lefébure, T., Pavinski Bitar, P. D., Lang, P., Richards, V. P., Eilertson, K., Do, T., Beighton, D., Zeng, L., Ahn, S.-J., et al. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mss278 · Cited by 198 · see citing works
The Surprising Creativity of Digital Evolution: A Collection of Anecdotes from the Evolutionary Computation and Artificial Life Research Communities
Lehman, J., Clune, J., Misevic, D., Adami, C., Altenberg, L., Beaulieu, J., Bentley, P. J., Bernard, S., Beslon, G., Bryson, D. M., et al. (2020) · Artificial Life · doi:10.1162/artl_a_00319 · Cited by 181 · see citing works
Adaptive Evolution ofEscherichia coliK-12 MG1655 during Growth on a Nonnative Carbon Source,<scp>l</scp>-1,2-Propanediol
Lee, D.-H., & Palsson, B. Ø. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00373-10 · Cited by 160 · see citing works
Culture History and Population Heterogeneity as Determinants of Bacterial Adaptation: the Adaptomics of a Single Environmental Transition
Ryall, B., Eydallin, G., & Ferenci, T. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05028-11 · Cited by 160 · see citing works
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes
Ivarsson, Y., Arnold, R., McLaughlin, M., Nim, S., Joshi, R., Ray, D., Liu, B., Teyra, J., Pawson, T., Moffat, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312296111 · Cited by 135 · see citing works
Evolution of competitive fitness in experimental populations of E. coli: What makes one genotype a better competitor than another?
Lenski, R. E., Mongold, J. A., Sniegowski, P. D., Travisano, M., Vasi, F., Gerrish, P. J., & Schmidt, T. M. (1998) · Antonie van Leeuwenhoek · doi:10.1023/a:1000675521611 · Cited by 152 · see citing works
Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast.
Lang, G. I., Parsons, L., & Gammie, A. E. (2013) · G3 Genes Genomes Genetics · doi:10.1534/g3.113.006429 · Cited by 107 · see citing works
Potential role of phenotypic mutations in the evolution of protein expression and stability
Goldsmith, M., & Tawfik, D. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809506106 · Cited by 81 · see citing works
The role of themutTgene ofEscherichia coliin maintaining replication fidelity
Fowler, R. G., & Schaaper, R. M. (1997) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1997.tb00344.x · Cited by 100 · see citing works
Phase Diagrams of Quasispecies Theory with Recombination and Horizontal Gene Transfer.
Park, J.-M., & Deem, M. W. (2007) · Physical Review Letters · doi:10.1103/physrevlett.98.058101 · Cited by 69 · see citing works
DNA precursor asymmetries, replication fidelity, and variable genome evolution
Mathews, C. K., & Ji, J. (1992) · BioEssays · doi:10.1002/bies.950140502 · Cited by 69 · see citing works
Mechanisms of genetic variation in polioviruses
Savolainen‐Kopra, C., & Blomqvist, S. (2010) · Reviews in Medical Virology · doi:10.1002/rmv.663 · Cited by 67 · see citing works
Adaptive Evolution of the Lactose Utilization Network in Experimentally Evolved Populations of Escherichia coli
Quan, S., Ray, J. C. J., Kwota, Z., Duong, T., Balázsi, G., Cooper, T. F., & Monds, R. D. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002444 · Cited by 59 · see citing works
Genetic Code Evolution Reveals the Neutral Emergence of Mutational Robustness, and Information as an Evolutionary Constraint
Massey, S. (2015) · Life · doi:10.3390/life5021301 · Cited by 38 · see citing works
“This analysis is an extension the observed inverse relationship between μ and genome size in a range of microbes [163].”
Background
Dissecting the Fidelity of Bacteriophage RB69 DNA Polymerase: Site-Specific Modulation of Fidelity by Polymerase Accessory Proteins
Bebenek, A., Carver, G. T., Dressman, H. K., Kadyrov, F. A., Haseman, J. K., Petrov, V., Konigsberg, W. H., Karam, J. D., & Drake, J. W. (2002) · Genetics · doi:10.1093/genetics/162.3.1003 · Cited by 39 · see citing works
Self-citation
Suppressors of Escherichia coli mutT: antimutators for DNA replication errors
Schaaper, R. M. (1996) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(95)00086-0 · Cited by 27 · see citing works
Inference of the Demographic Histories and Selective Effects of Human Gut Commensal Microbiota Over the Course of Human History
Mah, J. C., Lohmueller, K. E., & Garud, N. R. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf010 · Cited by 11 · see citing works

Authors: Drake, J. W.
Affiliations: National Institutes of Health (US)
Corresponding author: Drake, J W
ORCID: Drake, J W
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1991-08-15
Volume: 88
Issue: 16
Pages: 7160-7164
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.88.16.7160
PMC: PMC52253
OpenAlex: W1977852064
Cited by: 1,199
References: 56
Citations by year: 2026: 20 · 2025: 19 · 2024: 50 · 2023: 47 · 2022: 26 · 2021: 41 · 2020: 41 · 2019: 38 · 2018: 50 · 2017: 45 · 2016: 41 · 2015: 38 · 2014: 53 · 2013: 37 · 2012: 51
FWCI: 9.14
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: spontaneous mutation rate, genome size, haploid organisms, bacteriophages, yeast, filamentous fungi, mutation rate evolution
MeSH terms: Base Composition, Coliphages, DNA, Bacterial, DNA, Fungal, DNA, Viral, Escherichia coli, Biological Evolution, Genes, Bacterial, Genes, Fungal, Genes, Viral, Mutation, Neurospora crassa, Bacteriophage lambda, Saccharomyces cerevisiae, Species Specificity, T-Phages

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A constant rate of spontaneous mutation in DNA-based microbes.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks