The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Resistance against Herbicide Isoxaben and Cellulose Deficiency Caused by Distinct Mutations in Same Cellulose Synthase Isoform CESA6
Open accessAbstract
Isoxaben is a pre-emergence herbicide that inhibits cellulose biosynthesis in higher plants. Two loci identified by isoxaben-resistant mutants (ixr1-1,ixr1-2, and ixr2-1) in Arabidopsis have been reported previously. IXR1 was recently shown to encode the cellulose synthase catalytic subunit CESA3 (W.-R. Scheible, R. Eshed, T. Richmond, D. Delmer, and C. Somerville [2001] Proc Natl Acad Sci USA 98: 10079–10084). Here, we report on the cloning of IXR2, and show that it encodes another cellulose synthase isoform, CESA6. ixr2-1 carries a mutation substituting an amino acid close to the C terminus of CESA6 that is highly conserved among CESA family members. Transformation of wild-type plants with the mutated gene and not with the wild-type gene conferred increased resistance against the herbicide. The simplest interpretation for the existence of these two isoxaben-resistant loci is that CESA3 and CESA6 have redundant functions. However, loss of functionprocuste1 alleles of CESA6 were previously shown to have a strong growth defect and reduced cellulose content in roots and dark-grown hypocotyls. This indicates that in these mutants, the presence of CESA3 does not compensate for the absence of CESA6 in roots and dark-grown hypocotyls, which argues against redundant functions for CESA3 and CESA6. Together, these observations are compatible with a model in which CESA6 and CESA3 are active as a protein complex.
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Cites
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Cited by
Visualization of Cellulose Synthase Demonstrates Functional Association with Microtubules
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Signals that control plant vascular cell differentiation
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Metadata
- Authors
- Desprez, T., Vernhettes, S., Fagard, M., Refrégier, G., Desnos, T., Aletti, E., Py, N., Pelletier, S., & Höfte, H.
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-02-01
- Volume
- 128
- Issue
- 2
- Pages
- 482-490
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- OpenAlex
- W2147608991
- Cited by
- 313
- References
- 23
- FWCI
- 14.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Desprez, T., Vernhettes, S., Fagard, M., Refrégier, G., Desnos, T., Aletti, E., Py, N., Pelletier, S., & Höfte, H. (2002). Resistance against Herbicide Isoxaben and Cellulose Deficiency Caused by Distinct Mutations in Same Cellulose Synthase Isoform CESA6. Plant Physiology. https://doi.org/10.1104/pp.010822
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