The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Heavy Metal Stress. Activation of Distinct Mitogen-Activated Protein Kinase Pathways by Copper and Cadmium
Open accessAbstract
Excessive amounts of heavy metals adversely affect plant growth and development. Whereas some regions naturally contain high levels of heavy metals, anthropogenic release of heavy metals into the environment continuously increases soil contamination. The presence of elevated levels of heavy metal ions triggers a wide range of cellular responses including changes in gene expression and synthesis of metal-detoxifying peptides. To elucidate signal transduction events leading to the cellular response to heavy metal stress we analyzed protein phosphorylation induced by elevated levels of copper and cadmium ions as examples for heavy metals with different physiochemical properties and functions. Exposure of alfalfa (Medicago sativa) seedlings to excess copper or cadmium ions activated four distinct mitogen-activated protein kinases (MAPKs): SIMK, MMK2, MMK3, and SAMK. Comparison of the kinetics of MAPK activation revealed that SIMK, MMK2, MMK3, and SAMK are very rapidly activated by copper ions, while cadmium ions induced delayed MAPK activation. In protoplasts, the MAPK kinase SIMKK specifically mediated activation of SIMK and SAMK but not of MMK2 and MMK3. Moreover, SIMKK only conveyed MAPK activation by CuCl2 but not by CdCl2. These results suggest that plants respond to heavy metal stress by induction of several distinct MAPK pathways and that excess amounts of copper and cadmium ions induce different cellular signaling mechanisms in roots.
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Cites
Oxidative mechanisms in the toxicity of metal ions
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Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
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Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
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P HYTOCHELATINS AND M ETALLOTHIONEINS : Roles in Heavy Metal Detoxification and Homeostasis
Cobbett, C., & Goldsbrough, P. (2002) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.53.100301.135154 · Cited by 2,518
Copper toxicity, oxidative stress, and antioxidant nutrients
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Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
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“MAPKs are part of a phosphorylation cascade that is composed of three sequentially activated protein kinases: MAPKKK, MAPK kinase (MAPKK), and MAPK (Schaeffer and Weber, 1999; Widmann et al., 1999).”
BackgroundFunctional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants
Kovtun, Y., Chiu, W.-L., Tena, G., & Sheen, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2940 · Cited by 1,530
Cited by
Heavy Metal Contamination in Agricultural Soil: Environmental Pollutants Affecting Crop Health
Rashid, A., Schutte, B. J., Ulery, A., Deyholos, M. K., Sanogo, S., Lehnhoff, E. A., & Beck, L. (2023) · Agronomy · doi:10.3390/agronomy13061521 · Cited by 837
Emerging MAP kinase pathways in plant stress signalling
Nakagami, H., Pitzschke, A., & Hirt, H. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.05.009 · Cited by 676
Self-citationCadmium stress in plants: A critical review of the effects, mechanisms, and tolerance strategies
El Rasafi, T., Oukarroum, A., Haddioui, A., Song, H., Kwon, E. E., Bolan, N., Tack, F. M. G., Sebastian, A., Prasad, M. N. V., & Rinklebe, J. (2022) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2020.1835435 · Cited by 601
Shahzad, B., Tanveer, M., Che, Z., Rehman, A., Cheema, S. A., Sharma, A., Song, H., Rehman, S. U., & Zhaorong, D. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2017.09.066 · Cited by 325
Plant Adaptation and Phytoremediation
(2010) · Springer eBooks · doi:10.1007/978-90-481-9370-7 · Cited by 308
Metadata
- Authors
- Jonak, C., Nakagami, H., & Hirt, H.
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-10-01
- Volume
- 136
- Issue
- 2
- Pages
- 3276-3283
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- OpenAlex
- W2139202993
- Cited by
- 432
- References
- 44
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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