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Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

Pearson, Gray, Robinson, Fred, Beers Gibson, Tara, Xu, Bing-e, Karandikar, Mahesh, Berman, Kevin, Cobb, Melanie H.·2001·Endocrine Reviews
DOI 10.1210/edrv.22.2.0428
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Abstract

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.

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Metadata

Authors
Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.-E., Karandikar, M., Berman, K., & Cobb, M. H.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2001-04-01
Volume
22
Issue
2
Pages
153-183
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv.22.2.0428
OpenAlex
W1990065094
Cited by
4,034
References
24
FWCI
47.66
Type
journal article
Language
en
Open access
closed

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Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.-E., Karandikar, M., Berman, K., & Cobb, M. H. (2001). Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*. Endocrine Reviews. https://doi.org/10.1210/edrv.22.2.0428

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