The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Triple Loss of Function of Protein Phosphatases Type 2C Leads to Partial Constitutive Response to Endogenous Abscisic Acid
Open accessAbstract
The phytohormone abscisic acid (ABA) is a key regulator of plant growth and development as well as plant responses to situations of decreased water availability. Protein phosphatases type 2C (PP2Cs) from group A, which includes the ABI1/HAB1 and PP2CA branches, are key negative regulators of ABA signaling. Specifically, HAB1, ABI1, ABI2, and PP2CA have been shown to affect both seed and vegetative responses to ABA. To further understand their contribution to ABA signaling and to unravel possible genetic interactions and functional redundancy among them, we have generated different combinations of double and triple mutants impaired in these PP2Cs. Interestingly, hab1-1pp2ca-1 and abi1-2pp2ca-1 double mutants showed reduced water loss and enhanced resistance to drought stress, which further supports the role of PP2CA in vegetative responses to ABA. Two triple hab1-1abi1-2abi2-2 and hab1-1abi1-2pp2ca-1 mutants were generated, which showed an extreme response to exogenous ABA, impaired growth, and partial constitutive response to endogenous ABA. Thus, transcriptomic analysis revealed a partial up-regulation/down-regulation of a subset of ABA-responsive genes in both triple mutants in the absence of exogenous ABA. Comparison of ABA responses in the different pp2c mutants showed that a progressive increase in ABA sensitivity could be obtained through combined inactivation of these PP2Cs. These results indicate that ABA response is finely tuned by the integrated action of these genes, which is required to prevent a constitutive response to endogenous ABA that might have a deleterious effect on growth and development in the absence of environmental stress.
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Kim, K.-N., Cheong, Y. H., Grant, J. J., Pandey, G. K., & Luan, S. (2003) · The Plant Cell · doi:10.1105/tpc.006858 · Cited by 406
Cited by
Raghavendra, A. S., Gonugunta, V. K., Christmann, A., & Grill, E. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.04.006 · Cited by 1,309
Hubbard, K. E., Nishimura, N., Hitomi, K., Getzoff, E. D., & Schroeder, J. I. (2010) · Genes & Development · doi:10.1101/gad.1953910 · Cited by 667
Self-citationGonzalez-Guzman, M., Pizzio, G. A., Antoni, R., Vera-Sirera, F., Merilo, E., Bassel, G. W., Fernández, M. A., Holdsworth, M. J., Perez-Amador, M. A., Kollist, H., et al. (2012) · The Plant Cell · doi:10.1105/tpc.112.098574 · Cited by 579
Self-citationStructural Mechanism of Abscisic Acid Binding and Signaling by Dimeric PYR1
Nishimura, N., Hitomi, K., Arvai, A. S., Rambo, R. P., Hitomi, C., Cutler, S. R., Schroeder, J. I., & Getzoff, E. D. (2009) · Science · doi:10.1126/science.1181829 · Cited by 494
Self-citationHua, D., Wang, C., He, J., Liao, H., Duan, Y., Zhu, Z., Guo, Y., Chen, Z., & Gong, Z. (2012) · The Plant Cell · doi:10.1105/tpc.112.100107 · Cited by 417
Metadata
- Authors
- Rubio, S., Rodrigues, A., Saez, A., Dizon, M. B., Galle, A., Kim, T.-H., Santiago, J., Flexas, J., Schroeder, J. I., & Rodriguez, P. L.
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05-20
- Volume
- 150
- Issue
- 3
- Pages
- 1345-1355
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- OpenAlex
- W2122828310
- Cited by
- 326
- References
- 3
- FWCI
- 22.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rubio, S., Rodrigues, A., Saez, A., Dizon, M. B., Galle, A., Kim, T.-H., Santiago, J., Flexas, J., Schroeder, J. I., & Rodriguez, P. L. (2009). Triple Loss of Function of Protein Phosphatases Type 2C Leads to Partial Constitutive Response to Endogenous Abscisic Acid. Plant Physiology. https://doi.org/10.1104/pp.109.137174
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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