Cited by 264Photosynthetic Processes and MechanismsMitochondrial Function and PathologyPlant nutrient uptake and metabolism

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Mitochondrial Malate Dehydrogenase Lowers Leaf Respiration and Alters Photorespiration and Plant Growth in Arabidopsis

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Tomaz, Tiago, Bagard, Matthieu, Pracharoenwattana, Itsara, Lindén, Pernilla, Lee, Chun Pong, Carroll, Adam J., Ströher, Elke, Smith, Steven M., Gardeström, Per, Millar, A. Harvey·2010·Plant Physiology

DOI 10.1104/pp.110.161612PMC PMC2971595

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Abstract

Malate dehydrogenase (MDH) catalyzes a reversible NAD+-dependent-dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments. To explore the role of mitochondrial MDH (mMDH) in Arabidopsis (Arabidopsis thaliana), knockout single and double mutants for the highly expressed mMDH1 and lower expressed mMDH2 isoforms were constructed and analyzed. A mmdh1mmdh2 mutant has no detectable mMDH activity but is viable, albeit small and slow growing. Quantitative proteome analysis of mitochondria shows changes in other mitochondrial NAD-linked dehydrogenases, indicating a reorganization of such enzymes in the mitochondrial matrix. The slow-growing mmdh1mmdh2 mutant has elevated leaf respiration rate in the dark and light, without loss of photosynthetic capacity, suggesting that mMDH normally uses NADH to reduce oxaloacetate to malate, which is then exported to the cytosol, rather than to drive mitochondrial respiration. Increased respiratory rate in leaves can account in part for the low net CO2 assimilation and slow growth rate of mmdh1mmdh2. Loss of mMDH also affects photorespiration, as evidenced by a lower postillumination burst, alterations in CO2 assimilation/intercellular CO2 curves at low CO2, and the light-dependent elevated concentration of photorespiratory metabolites. Complementation of mmdh1mmdh2 with an mMDH cDNA recovered mMDH activity, suppressed respiratory rate, ameliorated changes to photorespiration, and increased plant growth. A previously established inverse correlation between mMDH and ascorbate content in tomato (Solanum lycopersicum) has been consolidated in Arabidopsis and may potentially be linked to decreased galactonolactone dehydrogenase content in mitochondria in the mutant. Overall, a central yet complex role for mMDH emerges in the partitioning of carbon and energy in leaves, providing new directions for bioengineering of plant growth rate and a new insight into the molecular mechanisms linking respiration and photosynthesis in plants.

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Genevestigator V3: A Reference Expression Database for the Meta‐Analysis of Transcriptomes
Hrúz, T., Laule, O., Szabo, G., Wessendorp, F., Stefan Bleuler, A., Oertle, L., Widmayer, P., Gruissem, W., & Philip Zimmermann, B. (2008) · Advances in Bioinformatics · doi:10.1155/2008/420747 · Cited by 1,910
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Heazlewood, J. L., Tonti‐Filippini, J., Gout, A. M., Day, D. A., Whelan, J., & Millar, A. H. (2004) · The Plant Cell · doi:10.1105/tpc.016055 · Cited by 575
Self-citation
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Show all 52 references

Research works printed but not linked: 1

Palmer, 1984, The mechanism and regulation of malate oxidation in isolated plant mitochondria, Physiol Veg, 22, 665

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Authors: Tomaz, T., Bagard, M., Pracharoenwattana, I., Lindén, P., Lee, C. P., Carroll, A. J., Ströher, E., Smith, S. M., Gardeström, P., & Millar, A. H.
Affiliations: Australian National University (AU)
ORCID: Bagard, Matthieu
Lindén, Pernilla
Lee, Chun Pong
Carroll, Adam J.
Ströher, Elke
Smith, Steven M.
Gardeström, Per
Millar, A. Harvey
Venue: Plant Physiology
Publisher: Oxford University Press (OUP)
Published: 2010-09-27
Volume: 154
Issue: 3
Pages: 1143-1157
ISSN: 0032-0889 (ISSN-L)
1532-2548
DOI: 10.1104/pp.110.161612
PMC: PMC2971595
OpenAlex: W2039278227
Cited by: 264
References: 52
Citations by year: 2026: 9 · 2025: 10 · 2024: 22 · 2023: 19 · 2022: 18 · 2021: 22 · 2020: 28 · 2019: 17 · 2018: 18 · 2017: 16 · 2016: 21 · 2015: 17 · 2014: 13 · 2013: 12 · 2012: 11
FWCI: 4.43
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor, 3773 d)
Locations: PLANT PHYSIOLOGY (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eCite Digital Repository (University of Tasmania) (submittedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Figshare (submittedVersion, cc-by)
ANU Open Research (Australian National University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
Keywords: mitochondrial malate dehydrogenase, leaf respiration, photorespiration, carbon assimilation, vitamin C, redox homeostasis, carbon allocation, plant growth rate, Arabidopsis thaliana
MeSH terms: Carbon Dioxide, Genetic Complementation Test, Malate Dehydrogenase, Mutation, Photosynthesis, Mutagenesis, Insertional, Arabidopsis, Plant Leaves, Cell Respiration, Mitochondrial Proteins, Arabidopsis Proteins, Gene Knockout Techniques

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Mitochondrial Malate Dehydrogenase Lowers Leaf Respiration and Alters Photorespiration and Plant Growth in Arabidopsis

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