The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
MdCOP1 Ubiquitin E3 Ligases Interact with MdMYB1 to Regulate Light-Induced Anthocyanin Biosynthesis and Red Fruit Coloration in Apple
Open accessAbstract
MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species.
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Cites
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Activation Tagging Identifies a Conserved MYB Regulator of Phenylpropanoid Biosynthesis
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Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10
Espley, R. V., Hellens, R. P., Putterill, J., Stevenson, D. E., Kutty‐Amma, S., & Allan, A. C. (2007) · The Plant Journal · doi:10.1111/j.1365-313x.2006.02964.x · Cited by 1,392
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Light-Induced Expression of a MYB Gene Regulates Anthocyanin Biosynthesis in Red Apples
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Cited by
Zhou, H., Lin‐Wang, K., Wang, H., Gu, C., Dare, A. P., Espley, R. V., He, H., Allan, A. C., & Han, Y. (2015) · The Plant Journal · doi:10.1111/tpj.12792 · Cited by 522
An, J.-P., Wang, X.-F., Li, Y.-Y., Song, L.-Q., Zhao, L.-L., You, C.-X., & Hao, Y.-J. (2018) · Plant Physiology · doi:10.1104/pp.18.00068 · Cited by 299
Self-citationHao, X., Zhong, Y., N�tzmann, H.-W., Fu, X., Yan, T., Shen, Q., Chen, M., Ma, Y., Zhao, J., Osbourn, A., et al. (2019) · Plant and Cell Physiology · doi:10.1093/pcp/pcz084 · Cited by 121
Metadata
- Authors
- Li, Y.-Y., Mao, K., Zhao, C., Zhao, X.-Y., Zhang, H.-L., Shu, H.-R., & Hao, Y.-J.
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-08-01
- Volume
- 160
- Issue
- 2
- Pages
- 1011-1022
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- OpenAlex
- W2045733785
- Cited by
- 489
- References
- 43
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Li, Y.-Y., Mao, K., Zhao, C., Zhao, X.-Y., Zhang, H.-L., Shu, H.-R., & Hao, Y.-J. (2012). MdCOP1 Ubiquitin E3 Ligases Interact with MdMYB1 to Regulate Light-Induced Anthocyanin Biosynthesis and Red Fruit Coloration in Apple. Plant Physiology. https://doi.org/10.1104/pp.112.199703
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