The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Peroxisomal Acyl-CoA Synthetase Activity Is Essential for Seedling Development in Arabidopsis thaliana
Open accessAbstract
In plants and other eukaryotes, long-chain acyl-CoAs are assumed to be imported into peroxisomes for beta-oxidation by an ATP binding cassette (ABC) transporter. However, two genes in Arabidopsis thaliana, LACS6 and LACS7, encode peroxisomal long-chain acyl-CoA synthetase (LACS) isozymes. To investigate the biochemical and biological roles of peroxisomal LACS, we identified T-DNA knockout mutants for both genes. The single-mutant lines, lacs6-1 and lacs7-1, were indistinguishable from the wild type in germination, growth, and reproductive development. By contrast, the lacs6-1 lacs7-1 double mutant was specifically defective in seed lipid mobilization and required exogenous sucrose for seedling establishment. This phenotype is similar to the A. thaliana pxa1 mutants deficient in the peroxisomal ABC transporter and other mutants deficient in beta-oxidation. Our results demonstrate that peroxisomal LACS activity and the PXA1 transporter are essential for early seedling growth. The peroxisomal LACS activity would be necessary if the PXA1 transporter delivered unesterified fatty acids into the peroxisomal matrix. Alternatively, PXA1 and LACS6/LACS7 may act in parallel pathways that are both required to ensure adequate delivery of acyl-CoA substrates for beta-oxidation and successful seedling establishment.
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Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
Mosser, J., Douar, A.-M., Sarde, C.-O., Kioschis, P., Feil, R., Moser, H., Poustka, A.-M., Mandel, J.-L., & Aubourg, P. (1993) · Nature · doi:10.1038/361726a0 · Cited by 1,202
Shani, N., & Valle, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11901 · Cited by 157
Cited by
Molecular Aspects of Seed Dormancy
Finkelstein, R., Reeves, W., Ariizumi, T., & Steber, C. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092740 · Cited by 1,379
Genetic Engineering of Algae for Enhanced Biofuel Production
Radakovits, R., Jinkerson, R. E., Darzins, A., & Posewitz, M. C. (2010) · Eukaryotic Cell · doi:10.1128/ec.00364-09 · Cited by 1,142
De Marcos Lousa, C., van Roermund, C. W. T., Postis, V. L. G., Dietrich, D., Kerr, I. D., Wanders, R. J. A., Baldwin, S. A., Baker, A., & Theodoulou, F. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218034110 · Cited by 158
A role for the human peroxisomal half-transporter ABCD3 in the oxidation of dicarboxylic acids
van Roermund, C. W. T., IJlst, L., Wagemans, T., Wanders, R. J. A., & Waterham, H. R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.12.001 · Cited by 101
Bai, F., Yu, L., Shi, J., Li‐Beisson, Y., & Liu, J. (2022) · New Phytologist · doi:10.1111/nph.17813 · Cited by 45
Metadata
- Authors
- Fulda, M., Schnurr, J., Abbadi, A., Heinz, E., & Browse, J.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01-23
- Volume
- 16
- Issue
- 2
- Pages
- 394-405
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2144462468
- Cited by
- 247
- References
- 2
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fulda, M., Schnurr, J., Abbadi, A., Heinz, E., & Browse, J. (2004). Peroxisomal Acyl-CoA Synthetase Activity Is Essential for Seedling Development in Arabidopsis thaliana. The Plant Cell. https://doi.org/10.1105/tpc.019646
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