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Cited by 295

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

The Arabidopsis Mutant sleepy1gar2-1 Protein Promotes Plant Growth by Increasing the Affinity of the SCFSLY1 E3 Ubiquitin Ligase for DELLA Protein Substrates[W]

Open access
Fu, Xiangdong, Richards, Donald E., Fleck, Barbara, Xie, Daoxin, Burton, Nicolas, Harberd, Nicholas P.·2004·The Plant Cell

Abstract

DELLA proteins restrain the cell proliferation and enlargement that characterizes the growth of plant organs. Gibberellin stimulates growth via 26S proteasome–dependent destruction of DELLAs, thus relieving DELLA-mediated growth restraint. Here, we show that the Arabidopsis thaliana sleepy1gar2-1 (sly1gar2-1) mutant allele encodes a mutant subunit (sly1gar2-1) of an SCFSLY1 E3 ubiquitin ligase complex. SLY1 (the wild-type form) and sly1gar2-1 both confer substrate specificity on this complex via specific binding to the DELLA proteins. However, sly1gar2-1 interacts more strongly with the DELLA target than does SLY1. In addition, the strength of the SCFSLY1–DELLA interaction is increased by target phosphorylation. Growth-promoting DELLA destruction is dependent on SLY1 availability, on the strength of the interaction between SLY1 and the DELLA target, and on promotion of the SCFSLY1–DELLA interaction by DELLA phosphorylation.

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Metadata

Authors
Fu, X., Richards, D. E., Fleck, B., Xie, D., Burton, N., & Harberd, N. P.
Venue
The Plant Cell
Published
2004-06-01
Volume
16
Issue
6
Pages
1406-1418
ISSN
  • 1040-4651 (ISSN-L)
  • 1532-298X
OpenAlex
W2108097646
Cited by
295
References
2
FWCI
20.24
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Arabidopsis Mutant sleepy1gar2-1 Protein Promotes Plant Growth by Increasing the Affinity of the SCFSLY1 E3 Ubiquitin Ligase for DELLA Protein Substrates[W]. https://app.cochat.ai/papers/10.1105/tpc.021386
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Fu, X., Richards, D. E., Fleck, B., Xie, D., Burton, N., & Harberd, N. P. (2004). The Arabidopsis Mutant sleepy1gar2-1 Protein Promotes Plant Growth by Increasing the Affinity of the SCFSLY1 E3 Ubiquitin Ligase for DELLA Protein Substrates[W]. The Plant Cell. https://doi.org/10.1105/tpc.021386

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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