The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The Arabidopsis Mutant sleepy1gar2-1 Protein Promotes Plant Growth by Increasing the Affinity of the SCFSLY1 E3 Ubiquitin Ligase for DELLA Protein Substrates[W]
Open accessAbstract
DELLA proteins restrain the cell proliferation and enlargement that characterizes the growth of plant organs. Gibberellin stimulates growth via 26S proteasome–dependent destruction of DELLAs, thus relieving DELLA-mediated growth restraint. Here, we show that the Arabidopsis thaliana sleepy1gar2-1 (sly1gar2-1) mutant allele encodes a mutant subunit (sly1gar2-1) of an SCFSLY1 E3 ubiquitin ligase complex. SLY1 (the wild-type form) and sly1gar2-1 both confer substrate specificity on this complex via specific binding to the DELLA proteins. However, sly1gar2-1 interacts more strongly with the DELLA target than does SLY1. In addition, the strength of the SCFSLY1–DELLA interaction is increased by target phosphorylation. Growth-promoting DELLA destruction is dependent on SLY1 availability, on the strength of the interaction between SLY1 and the DELLA target, and on promotion of the SCFSLY1–DELLA interaction by DELLA phosphorylation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840
Mechanisms Underlying Ubiquitination
Pickart, C. M. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.503 · Cited by 3,184
‘Green revolution’ genes encode mutant gibberellin response modulators
Peng, J., Richards, D. E., Hartley, N. M., Murphy, G. P., Devos, K. M., Flintham, J. E., Beales, J., Fish, L. J., Worland, A. J., Pelica, F., et al. (1999) · Nature · doi:10.1038/22307 · Cited by 2,252
Self-citationStructure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex
Zheng, N., Schulman, B. A., Song, L., Miller, J. J., Jeffrey, P. D., Wang, P., Chu, C., Koepp, D. M., Elledge, S. J., Pagano, M., et al. (2002) · Nature · doi:10.1038/416703a · Cited by 1,507
SCF and Cullin/RING H2-Based Ubiquitin Ligases
Deshaies, R. J. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.435 · Cited by 1,242
The Arabidopsis GAI gene defines a signaling pathway that negatively regulates gibberellin responses
Peng, J., Carol, P., Richards, D. E., King, K. E., Cowling, R. J., Murphy, G. P., & Harberd, N. P. (1997) · Genes & Development · doi:10.1101/gad.11.23.3194 · Cited by 1,153
Self-citationAuxin promotes Arabidopsis root growth by modulating gibberellin response
Fu, X., & Harberd, N. P. (2003) · Nature · doi:10.1038/nature01387 · Cited by 818
Self-citationSilverstone, A. L., Ciampaglio, C. N., & Sun, T.-P. (1998) · The Plant Cell · doi:10.1105/tpc.10.2.155 · Cited by 786
Induction and analysis of gibberellin sensitive mutants in Arabidopsis thaliana (L.) heynh.
Koornneef, M., & van der Veen, J. H. (1980) · Theoretical and Applied Genetics · doi:10.1007/bf00265176 · Cited by 697
The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis
Gagne, J. M., Downes, B. P., Shiu, S.-H., Durski, A. M., & Vierstra, R. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162339999 · Cited by 695
The SCFCOI1 Ubiquitin-Ligase Complexes Are Required for Jasmonate Response in Arabidopsis
Xu, L., Liu, F., Lechner, E., Genschik, P., Crosby, W. L., Ma, H., Peng, W., Huang, D., & Xie, D. (2002) · The Plant Cell · doi:10.1105/tpc.003368 · Cited by 692
Self-citationAccumulation of Phosphorylated Repressor for Gibberellin Signaling in an F-box Mutant
Sasaki, A., Itoh, H., Gomi, K., Ueguchi-Tanaka, M., Ishiyama, K., Kobayashi, M., Jeong, D.-H., An, G., Kitano, H., Ashikari, M., et al. (2003) · Science · doi:10.1126/science.1081077 · Cited by 678
Lee, S., Cheng, H., King, K. E., Wang, W., He, Y., Hussain, A., Lo, J., Harberd, N. P., & Peng, J. (2002) · Genes & Development · doi:10.1101/gad.969002 · Cited by 646
Self-citationThe Arabidopsis SLEEPY1 Gene Encodes a Putative F-Box Subunit of an SCF E3 Ubiquitin Ligase[W]
McGinnis, K. M., Thomas, S. G., Soule, J. D., Strader, L. C., Zale, J. M., Sun, T.-P., & Steber, C. M. (2003) · The Plant Cell · doi:10.1105/tpc.010827 · Cited by 594
Gibberellin regulates Arabidopsis floral development via suppression of DELLA protein function
Cheng, H., Qin, L., Lee, S., Fu, X., Richards, D. E., Cao, D., Luo, D., Harberd, N. P., & Peng, J. (2004) · Development · doi:10.1242/dev.00992 · Cited by 590
Self-citationThe ubiquitin/26S proteasome pathway, the complex last chapter in the life of many plant proteins
Vierstra, R. (2003) · Trends in Plant Science · doi:10.1016/s1360-1385(03)00014-1 · Cited by 545
Richards, D. E., King, K. E., Ait-ali, T., & Harberd, N. P. (2001) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.52.1.67 · Cited by 515
Self-citationItoh, H., Ueguchi-Tanaka, M., Sato, Y., Ashikari, M., & Matsuoka, M. (2002) · The Plant Cell · doi:10.1105/tpc.010319 · Cited by 513
Skp2 is oncogenic and overexpressed in human cancers
Gstaiger, M., Jordan, R., Lim, M., Catzavelos, C., Mestan, J., Slingerland, J., & Krek, W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081474898 · Cited by 505
Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis
Patton, E. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01473-5 · Cited by 500
The DELLA motif is essential for gibberellin-induced degradation of RGA
Dill, A., Jung, H.-S., & Sun, T.-P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251534098 · Cited by 482
Repressing a Repressor: Gibberellin-Induced Rapid Reduction of the RGA Protein in Arabidopsis
Silverstone, A. L., Jung, H.-S., Dill, A., Kawaide, H., Kamiya, Y., & Sun, T.-P. (2001) · The Plant Cell · doi:10.1105/tpc.010047 · Cited by 472
Dill, A., & Sun, T.-P. (2001) · Genetics · doi:10.1093/genetics/159.2.777 · Cited by 465
A Role for Brassinosteroids in Germination in Arabidopsis
Steber, C. M., & McCourt, P. (2001) · Plant Physiology · doi:10.1104/pp.125.2.763 · Cited by 461
Association of dwarfism and floral induction with a grape ‘green revolution’ mutation
Boss, P. K., & Thomas, M. R. (2002) · Nature · doi:10.1038/416847a · Cited by 456
Achard, P., Vriezen, W. H., Van Der Straeten, D., & Harberd, N. P. (2003) · The Plant Cell · doi:10.1105/tpc.015685 · Cited by 454
Self-citationDegradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
Busino, L., Donzelli, M., Chiesa, M., Guardavaccaro, D., Ganoth, D., Valerio Dorrello, N., Hershko, A., Pagano, M., & Draetta, G. F. (2003) · Nature · doi:10.1038/nature02082 · Cited by 447
Arabidopsis RGL1 Encodes a Negative Regulator of Gibberellin Responses
Wen, C.-K., & Chang, C. (2002) · The Plant Cell · doi:10.1105/tpc.010325 · Cited by 358
Jacobsen, S. E., Binkowski, K. A., & Olszewski, N. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9292 · Cited by 355
A gibberellin insensitive mutant of Arabidopsis thaliana
Koorneef, M., Elgersma, A., Hanhart, C. J., van Loenen‐Martinet, E. P., van Rijn, L., & Zeevaart, J. A. D. (1985) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1985.tb02355.x · Cited by 340
Gibberellins: perception, transduction and responses
Hooley, R. (1994) · Plant Molecular Biology · doi:10.1007/bf00016489 · Cited by 319
Mutants at the Slender1 Locus of Barley cv Himalaya. Molecular and Physiological Characterization
Chandler, P. M., Marion-Poll, A., Ellis, M., & Gubler, F. (2002) · Plant Physiology · doi:10.1104/pp.010917 · Cited by 305
Gibberellin Signaling in Barley Aleurone Cells. Control of SLN1 and GAMYB Expression
Gubler, F., Chandler, P. M., White, R. G., Llewellyn, D. J., & Jacobsen, J. V. (2002) · Plant Physiology · doi:10.1104/pp.010918 · Cited by 297
Gomi, K., Sasaki, A., Itoh, H., Ueguchi‐Tanaka, M., Ashikari, M., Kitano, H., & Matsuoka, M. (2004) · The Plant Journal · doi:10.1111/j.1365-313x.2003.01990.x · Cited by 291
Gibberellin-Mediated Proteasome-Dependent Degradation of the Barley DELLA Protein SLN1 Repressor
Fu, X., Richards, D. E., Ait-ali, T., Hynes, L. W., Ougham, H., Peng, J., & Harberd, N. P. (2002) · The Plant Cell · doi:10.1105/tpc.006197 · Cited by 289
Self-citationKing, K. E., Moritz, T., & Harberd, N. P. (2001) · Genetics · doi:10.1093/genetics/159.2.767 · Cited by 286
Self-citationZhou, P., & Howley, P. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80156-2 · Cited by 256
Hedden, P., & Graebe, J. E. (1985) · Journal of Plant Growth Regulation · doi:10.1007/bf02266949 · Cited by 235
The diverse roles of ubiquitin and the 26S proteasome in the life of plants
Sullivan, J. A., Shirasu, K., & Deng, X. W. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1228 · Cited by 235
Isolation of the GA-Response Mutant sly1 as a Suppressor of ABI1-1 in Arabidopsis thaliana
Steber, C. M., Cooney, S. E., & McCourt, P. (1998) · Genetics · doi:10.1093/genetics/149.2.509 · Cited by 220
Lisztwan, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.368 · Cited by 203
Chemical regulation of vegetative growth∗
Davis, T. D., Curry, E. A., & Steffens, G. L. (1991) · Critical Reviews in Plant Sciences · doi:10.1080/07352689109382310 · Cited by 187
Jackson, P. K., & Eldridge, A. G. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00538-5 · Cited by 154
Phenotypic Suppression of the Gibberellin-Insensitive Mutant (gai) of Arabidopsis
Wilson, R. N., & Somerville, C. R. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.2.495 · Cited by 125
Zhao, D., Ni, W., Feng, B., Han, T., Petrasek, M. G., & Mā, H. (2003) · PLANT PHYSIOLOGY · doi:10.1104/pp.103.024703 · Cited by 125
The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development
Liu, F., Ni, W., Griffith, M. E., Huang, Z., Chang, C., Peng, W., Mā, H., & Xie, D. (2003) · The Plant Cell · doi:10.1105/tpc.017772 · Cited by 124
Self-citationHarberd, N. P. (2003) · Science · doi:10.1126/science.1083217 · Cited by 111
Self-citationExpression of Arabidopsis GAI in Transgenic Rice Represses Multiple Gibberellin Responses
Fu, X., Sudhakar, D., Peng, J., Richards, D. E., Christou, P., & Harberd, N. P. (2001) · The Plant Cell · doi:10.1105/tpc.010020 · Cited by 97
Self-citationFleck, B., & Harberd, N. P. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01478.x · Cited by 89
Self-citationPeng, J., Richards, D. E., Möritz, T., Caño‐Delgado, A. I., & Harberd, N. P. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.119.4.1199 · Cited by 86
Self-citationSwain, S. M., Tseng, T., Thornton, T. M., Gopalraj, M., & Olszewski, N. E. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.020002 · Cited by 83
Hershko, A. (1998) · Springer eBooks · doi:10.1007/978-1-4899-1922-9_1 · Cited by 37
Cited by
Molecular Aspects of Seed Dormancy
Finkelstein, R., Reeves, W., Ariizumi, T., & Steber, C. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092740 · Cited by 1,379
Coordinated regulation of Arabidopsis thaliana development by light and gibberellins
Feng, S., Martinez, C., Gusmaroli, G., Wang, Y., Zhou, J., Wang, F., Chen, L., Yu, L., Iglesias-Pedraz, J. M., Kircher, S., et al. (2008) · Nature · doi:10.1038/nature06448 · Cited by 1,115
Self-citationGibberellin signaling in plants
Davière, J.-M., & Achard, P. (2013) · Development · doi:10.1242/dev.087650 · Cited by 908
Gibberellin-induced DELLA recognition by the gibberellin receptor GID1
Murase, K., Hirano, Y., Sun, T.-P., & Hakoshima, T. (2008) · Nature · doi:10.1038/nature07519 · Cited by 786
Global Analysis of DELLA Direct Targets in Early Gibberellin Signaling in Arabidopsis
Zentella, R., Zhang, Z.-L., Park, M., Thomas, S. G., Endo, A., Murase, K., Fleet, C. M., Jikumaru, Y., Nambara, E., Kamiya, Y., et al. (2007) · The Plant Cell · doi:10.1105/tpc.107.054999 · Cited by 678
Metadata
- Authors
- Fu, X., Richards, D. E., Fleck, B., Xie, D., Burton, N., & Harberd, N. P.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-06-01
- Volume
- 16
- Issue
- 6
- Pages
- 1406-1418
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2108097646
- Cited by
- 295
- References
- 52
- FWCI
- 20.24
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
