The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Maize rough sheath2 and Its Arabidopsis Orthologue ASYMMETRIC LEAVES1 Interact with HIRA, a Predicted Histone Chaperone, to Maintain knox Gene Silencing and Determinacy during Organogenesis
Abstract
Plant shoots are characterized by indeterminate growth resulting from the action of a population of stem cells in the shoot apical meristem (SAM). Indeterminacy within the SAM is specified in part by the class I knox homeobox genes. The myb domain proteins rough sheath2 (RS2) and ASYMMETRIC LEAVES1 (AS1) from maize (Zea mays) and Arabidopsis thaliana, respectively, are required to establish determinacy during leaf development. These proteins are part of a cellular memory system that in response to a stem cell–derived signal keeps knox genes in an off state during organogenesis. Here, we show that RS2/AS1 can form conserved protein complexes through interaction with the DNA binding factor ASYMMETRIC LEAVES2, a predicted RNA binding protein (RIK, for RS2-Interacting KH protein), and a homologue of the chromatin-remodeling protein HIRA. Partial loss of HIRA function in Arabidopsis results in developmental defects comparable to those of as1 and causes reactivation of knox genes in developing leaves, demonstrating a direct role for HIRA in knox gene repression and the establishment of determinacy during leaf formation. Our data suggest that RS2/AS1 and HIRA mediate the epigenetic silencing of knox genes, possibly by modulating chromatin structure. Components of this process are conserved in animals, suggesting the possibility that a similar epigenetic mechanism maintains determinacy during both plant and animal development.
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A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis
Long, J. A., Moan, E. I., Medford, J. I., & Barton, M. K. (1996) · Nature · doi:10.1038/379066a0 · Cited by 1,537
Zhang, R., Poustovoitov, M. V., Ye, X., Santos, H. A., Chen, W., Daganzo, S. M., Erzberger, J. P., Serebriiskii, I. G., Canutescu, A. A., Dunbrack, R. L., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.10.019 · Cited by 699
Cited by
Tian, F., Bradbury, P. J., Brown, P. J., Hung, H., Sun, Q., Flint-Garcia, S., Rocheford, T. R., McMullen, M. D., Holland, J. B., & Buckler, E. S. (2011) · Nature Genetics · doi:10.1038/ng.746 · Cited by 1,043
Molecular dissection of formation of senescence-associated heterochromatin foci
Zhang, R., Chen, W., & Adams, P. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02019-06 · Cited by 415
Defining the boundaries: structure and function of LOB domain proteins
Majer, C., & Hochholdinger, F. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2010.09.009 · Cited by 272
Arabidopsis JAGGED LATERAL ORGANS Is Expressed in Boundaries and Coordinates KNOX and PIN Activity
Borghi, L., Bureau, M., & Simon, R. (2007) · The Plant Cell · doi:10.1105/tpc.106.047159 · Cited by 161
Ikezaki, M., Kojima, M., Sakakibara, H., Kojima, S., Ueno, Y., Machida, C., & Machida, Y. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2009.04033.x · Cited by 97
Metadata
- Authors
- Phelps-Durr, T. L., Thomas, J., Vahab, P., & Timmermans, M. C. P.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-10-21
- Volume
- 17
- Issue
- 11
- Pages
- 2886-2898
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2169367914
- Cited by
- 206
- References
- 2
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Maize rough sheath2 and Its Arabidopsis Orthologue ASYMMETRIC LEAVES1 Interact with HIRA, a Predicted Histone Chaperone, to Maintain knox Gene Silencing and Determinacy during Organogenesis. https://app.cochat.ai/papers/10.1105/tpc.105.035477
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- Phelps-Durr, T. L., Thomas, J., Vahab, P., & Timmermans, M. C. P. (2005). Maize rough sheath2 and Its Arabidopsis Orthologue ASYMMETRIC LEAVES1 Interact with HIRA, a Predicted Histone Chaperone, to Maintain knox Gene Silencing and Determinacy during Organogenesis. The Plant Cell. https://doi.org/10.1105/tpc.105.035477
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