The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering of Arabidopsis
Open accessAbstract
The CCT (for CONSTANS, CONSTANS-LIKE, TOC1) domain is found in 45 Arabidopsis thaliana proteins involved in processes such as photoperiodic flowering, light signaling, and regulation of circadian rhythms. We show that this domain exhibits similarities to yeast HEME ACTIVATOR PROTEIN2 (HAP2), which is a subunit of the HAP2/HAP3/HAP5 trimeric complex that binds to CCAAT boxes in eukaryotic promoters. Moreover, we demonstrate that CONSTANS (CO), which promotes Arabidopsis flowering, interacts with At HAP3 and At HAP5 in yeast, in vitro, and in planta. Mutations in CO that delay flowering affect residues highly conserved between CCT and the DNA binding domain of HAP2. Taken together, these data suggest that CO might replace At HAP2 in the HAP complex to form a trimeric CO/At HAP3/At HAP5 complex. Flowering was delayed by overexpression of At HAP2 or At HAP3 throughout the plant or in phloem companion cells, where CO is expressed. This phenotype was correlated with reduced abundance of FLOWERING LOCUS T (FT) mRNA and no change in CO mRNA levels. At HAP2 or At HAP3 overexpression may therefore impair formation of a CO/At HAP3/At HAP5 complex leading to reduced expression of FT. During plant evolution, the number of genes encoding HAP proteins was greatly amplified, and these proteins may have acquired novel functions, such as mediating the effect of CCT domain proteins on gene expression.
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Cites
Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana
Alonso, J. M., Stepanova, A. N., Leisse, T. J., Kim, C. J., Chen, H., Shinn, P., Stevenson, D. K., Zimmerman, J., Barajas, P., Cheuk, R., et al. (2003) · Science · doi:10.1126/science.1086391 · Cited by 5,102
FD, a bZIP Protein Mediating Signals from the Floral Pathway Integrator FT at the Shoot Apex
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Self-citationActivation Tagging of the Floral Inducer FT
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CONSTANS mediates between the circadian clock and the control of flowering in Arabidopsis
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Self-citationDistinct Roles of CONSTANS Target Genes in Reproductive Development of Arabidopsis
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A Pair of Related Genes with Antagonistic Roles in Mediating Flowering Signals
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Andrés, F., & Coupland, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3291 · Cited by 1,538
Self-citationLi, W.-X., Oono, Y., Zhu, J., He, X.-J., Wu, J.-M., Iida, K., Lu, X.-Y., Cui, X., Jin, H., & Zhu, J.-K. (2008) · The Plant Cell · doi:10.1105/tpc.108.059444 · Cited by 915
Breeze, E., Harrison, E., McHattie, S., Hughes, L., Hickman, R., Hill, C., Kiddle, S., Kim, Y.-S., Penfold, C. A., Jenkins, D., et al. (2011) · The Plant Cell · doi:10.1105/tpc.111.083345 · Cited by 868
Yan, W.-H., Wang, P., Chen, H.-X., Zhou, H.-J., Li, Q.-P., Wang, C.-R., Ding, Z.-H., Zhang, Y.-S., Yu, S.-B., Xing, Y.-Z., et al. (2011) · Molecular Plant · doi:10.1093/mp/ssq070 · Cited by 585
Metadata
- Authors
- Wenkel, S., Turck, F., Singer, K., Gissot, L., Le Gourrierec, J., Samach, A., & Coupland, G.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11-01
- Volume
- 18
- Issue
- 11
- Pages
- 2971-2984
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2167637196
- Cited by
- 622
- References
- 56
- FWCI
- 24.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering of Arabidopsis. https://app.cochat.ai/papers/10.1105/tpc.106.043299
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- Wenkel, S., Turck, F., Singer, K., Gissot, L., Le Gourrierec, J., Samach, A., & Coupland, G. (2006). CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering of Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.106.043299
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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