The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
SIAMESE, a Plant-Specific Cell Cycle Regulator, Controls Endoreplication Onset in Arabidopsis thaliana
Open accessAbstract
Recessive mutations in the SIAMESE (SIM) gene of Arabidopsis thaliana result in multicellular trichomes harboring individual nuclei with a low ploidy level, a phenotype strikingly different from that of wild-type trichomes, which are single cells with a nuclear DNA content of ∼16C to 32C. These observations suggested that SIM is required to suppress mitosis as part of the switch to endoreplication in trichomes. Here, we demonstrate that SIM encodes a nuclear-localized 14-kD protein containing a cyclin binding motif and a motif found in ICK/KRP (for Interactors of Cdc2 kinase/Kip-related protein) cell cycle inhibitor proteins. Accordingly, SIM was found to associate with D-type cyclins and CDKA;1. Homologs of SIM were detected in other dicots and in monocots but not in mammals or fungi. SIM proteins are expressed throughout the shoot apical meristem, in leaf primordia, and in the elongation zone of the root and are localized to the nucleus. Plants overexpressing SIM are slow-growing and have narrow leaves and enlarged epidermal cells with an increased DNA content resulting from additional endocycles. We hypothesize that SIM encodes a plant-specific CDK inhibitor with a key function in the mitosis-to-endoreplication transition.
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Cites
Floral dip: a simplified method forAgrobacterium‐mediated transformation ofArabidopsis thaliana
Clough, S. J., & Bent, A. F. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00343.x · Cited by 21,934
Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis
Rogers, S., Wells, R., & Rechsteiner, M. (1986) · Science · doi:10.1126/science.2876518 · Cited by 2,537
Binary Agrobacterium vectors for plant transformation
Bevan, M. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.22.8711 · Cited by 2,166
A novel method for real time quantitative RT-PCR.
Gibson, U. E., Heid, C. A., & Williams, P. M. (1996) · Genome Research · doi:10.1101/gr.6.10.995 · Cited by 2,075
Out of Eden: Stem Cells and Their Niches
Watt, F. M., & Hogan, A. B. L. M. (2000) · Science · doi:10.1126/science.287.5457.1427 · Cited by 1,758
A Gene Expression Map of the Arabidopsis Root
Birnbaum, K., Shasha, D. E., Wang, J. Y., Jung, J. W., Lambert, G. M., Galbraith, D. W., & Benfey, P. N. (2003) · Science · doi:10.1126/science.1090022 · Cited by 1,258
An improved PCR method for walking in uncloned genomic DNA
Siebert, P. D., Chenchik, A., Kellogg, D. E., Lukyanov, K. A., & Lukyanov, S. A. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.6.1087 · Cited by 1,014
Inflorescence Commitment and Architecture in Arabidopsis
Bradley, D., Ratcliffe, O., Vincent, C., Carpenter, R., & Coen, E. (1997) · Science · doi:10.1126/science.275.5296.80 · Cited by 879
Edgar, B. A., & Orr-Weaver, T. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00334-8 · Cited by 846
A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis
Zhang, F., Gonzalez, A., Zhao, M., Payne, C. T., & Lloyd, A. (2003) · Development · doi:10.1242/dev.00681 · Cited by 799
Cited by
Roeder, A. H. K., Chickarmane, V., Cunha, A., Obara, B., Manjunath, B. S., & Meyerowitz, E. M. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000367 · Cited by 309
Cyclin dependent kinases and their role in regulation of plant cell cycle
Tank, J. G., & Thaker, V. S. (2011) · Biologia plantarum · doi:10.1007/s10535-011-0031-9 · Cited by 76
Mahalingam, R., Duhan, N., Kaundal, R., Smertenko, A., Nazarov, T., & Bregitzer, P. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1066421 · Cited by 53
Metadata
- Authors
- Churchman, M. L., Brown, M. L., Kato, N., Kirik, V., Hülskamp, M., Inzé, D., De Veylder, L., Walker, J. D., Zheng, Z., Oppenheimer, D. G., Gwin, T., Churchman, J., & Larkin, J. C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11-01
- Volume
- 18
- Issue
- 11
- Pages
- 3145-3157
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2150370714
- Cited by
- 285
- References
- 44
- FWCI
- 18.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Churchman, M. L., Brown, M. L., Kato, N., Kirik, V., Hülskamp, M., Inzé, D., De Veylder, L., Walker, J. D., Zheng, Z., Oppenheimer, D. G., Gwin, T., Churchman, J., & Larkin, J. C. (2006). SIAMESE, a Plant-Specific Cell Cycle Regulator, Controls Endoreplication Onset in Arabidopsis thaliana. The Plant Cell. https://doi.org/10.1105/tpc.106.044834
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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