The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Variability in the Control of Cell Division Underlies Sepal Epidermal Patterning in Arabidopsis thaliana
Open accessAbstract
How growth and proliferation are precisely controlled in organs during development and how the regulation of cell division contributes to the formation of complex cell type patterns are important questions in developmental biology. Such a pattern of diverse cell sizes is characteristic of the sepals, the outermost floral organs, of the plant Arabidopsis thaliana. To determine how the cell size pattern is formed in the sepal epidermis, we iterate between generating predictions from a computational model and testing these predictions through time-lapse imaging. We show that the cell size diversity is due to the variability in decisions of individual cells about when to divide and when to stop dividing and enter the specialized endoreduplication cell cycle. We further show that altering the activity of cell cycle inhibitors biases the timing and changes the cell size pattern as our model predicts. Models and observations together demonstrate that variability in the time of cell division is a major determinant in the formation of a characteristic pattern.
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Cites
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Self-citationGenetic interactions among floral homeotic genes of Arabidopsis
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Cited by
Effects of cell-cycle-dependent expression on random fluctuations in protein levels
Soltani, M., & Singh, A. (2016) · Royal Society Open Science · doi:10.1098/rsos.160578 · Cited by 32
Metadata
- Authors
- Roeder, A. H. K., Chickarmane, V., Cunha, A., Obara, B., Manjunath, B. S., & Meyerowitz, E. M.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-05-11
- Volume
- 8
- Issue
- 5
- Pages
- e1000367
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2111311160
- Cited by
- 309
- References
- 74
- FWCI
- 22.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Roeder, A. H. K., Chickarmane, V., Cunha, A., Obara, B., Manjunath, B. S., & Meyerowitz, E. M. (2010). Variability in the Control of Cell Division Underlies Sepal Epidermal Patterning in Arabidopsis thaliana. PLoS Biology. https://doi.org/10.1371/journal.pbio.1000367
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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