Cyclin dependent kinases and their role in regulation of plant cell cycle
Open accessAbstract
Plants have capability to optimize its architecture by using CDK pathways. It involves diverse types of cyclin dependent kinase enzymes (CDKs). CDKs are classified in to eight classes (CDKA to CDKG and CKL) based on the recognized cyclin-binding domains. These enzymes require specific cyclin proteins to get activated. They form complex with cyclin subunits and phosphorylate key target proteins. Phosphorylation of these target proteins is essential to drive cell cycle further from one phase to another phase. During cell division, the activity of cyclin dependent kinase is controlled by CDK interactor/inhibitor of CDKs (ICK) and Kip-related proteins (KRPs). They bind with specific CDK/cyclin complex and help in controlling CDKs activity. Since cell cycle can be progressed further only by synthesis and destruction of cyclins, they are quickly degraded using ubiquitination-proteasome pathway. Ubiquitylation reaction is followed by DNA duplication and cell division process. These two processes are regulated by two complexes known as Skp1/cullin/F-box (SCF)-related complex and the anaphase-promoting complex/cyclosome (APC/C). SCF allows cell to enter from G1 to S phase and APC/C allows cell to enter from G2 to M phase. When all these above processes of cell division are going on, genes of cyclin dependent kinases gets activated one by one simultaneously and help in regulation of CDK pathways. How cell cycle is regulated by CDKs is discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The development of plant organs directly depends on the frequency of cell division, parameters of the cell cycle, number, and size of the cells.
“The development of plant organs directly depends on the frequency of cell division, parameters of the cell cycle, number, and size of the cells.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mechanisms Underlying Ubiquitination
Pickart, C. M. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.503 · Cited by 3,731 · see citing works
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
Morgan, D. O. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.261 · Cited by 2,248 · see citing works
Evans, T., Rosenthal, E. T., Youngblom, J., Distel, D. L., & Hunt, T. (1983) · Cell · doi:10.1016/0092-8674(83)90420-8 · Cited by 1,516 · see citing works
S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
Hoyt, M. A., Totis, L., & Roberts, B. T. (1991) · Cell · doi:10.1016/0092-8674(81)90014-3 · Cited by 1,138 · see citing works
The SCF ubiquitin ligase: insights into a molecular machine
Cardozo, T., & Pagano, M. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1471 · Cited by 1,114 · see citing works
Mechanism and function of deubiquitinating enzymes
Amerik, A. Y., & Hochstrasser, M. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.10.003 · Cited by 978 · see citing works
The Anaphase-Promoting Complex
Peters, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00540-3 · Cited by 909 · see citing works
Cell Cycle Regulation in Plant Development
Inzé, D., & Veylder, L. D. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090431 · Cited by 880 · see citing works
Nasmyth, K. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091334 · Cited by 805 · see citing works
Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.
Lohka, M. J., Hayes, M. K., & Maller, J. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.9.3009 · Cited by 644 · see citing works
Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis
Veylder, L. D., Beeckman, T., Beemster, G. T. S., Krols, L., Terras, F. R. G., Landrieu, I., Schueren, E. V. D., Maes, S., Naudts, M., & Inzé, D. (2001) · The Plant Cell · doi:10.1105/tpc.010087 · Cited by 640 · see citing works
Cyclins and cyclin-dependent kinases: a biochemical view
Pines, J. (1995) · Biochemical Journal · doi:10.1042/bj3080697 · Cited by 538 · see citing works
Menges, M., de Jager, S. M., Gruissem, W., & Murray, J. A. H. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2004.02319.x · Cited by 492 · see citing works
Mitotic Regulation of the APC Activator Proteins CDC20 and CDH1
Kramer, E. R., Scheuringer, N., Podtelejnikov, A. V., Mann, M., & Peters, J. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1555 · Cited by 455 · see citing works
Wang, H., Qi, Q., Schorr, P., Cutler, A. J., Crosby, W. L., & Fowke, L. C. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00231.x · Cited by 425 · see citing works
Hemerly, A. S., Engler, J. D. A., Bergounioux, C., et al. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00064.x · Cited by 416 · see citing works
Cullin‐based ubiquitin ligases: Cul3–BTB complexes join the family
Pintard, L., Willems, A. R., & Peter, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600186 · Cited by 413 · see citing works
Cope, G. A., & Deshaies, R. J. (2003) · Cell · doi:10.1016/s0092-8674(03)00722-0 · Cited by 409 · see citing works
The ins and outs of the plant cell cycle
Veylder, L. D., Beeckman, T., & Inzé, D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2227 · Cited by 389 · see citing works
Regulation of APC-Cdc20 by the spindle checkpoint.
Yu, H.-T. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00382-4 · Cited by 379 · see citing works
A human RNA polymerase II complex associated with SRB and DNA-repair proteins
Maldonado, E., Shiekhattar, R., Sheldon, M., Cho, H. K., Drapkin, R., Rickert, P., Lees, E. M., Anderson, C. W., Linn, S., & Reinberg, D. (1996) · Nature · doi:10.1038/381086a0 · Cited by 351 · see citing works
Checkpoint Protein BubR1 Acts Synergistically with Mad2 to Inhibit Anaphase-promoting Complex
Fang, G. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-09-0437 · Cited by 332 · see citing works
NEDD8 Modification of CUL1 Dissociates p120CAND1, an Inhibitor of CUL1-SKP1 Binding and SCF Ligases
Liu, J., Furukawa, M., Matsumoto, T., & Xiong, Y. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00783-9 · Cited by 319 · see citing works
APC/C and SCF: Controlling Each Other and the Cell Cycle
Vodermaier, H. C. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.020 · Cited by 318 · see citing works
Boudolf, V., Vlieghe, K., Beemster, G. T. S., Magyar, Z., Acosta, J. A. T., Maes, S., Schueren, E. V. D., Inzé, D., & Veylder, L. D. (2004) · The Plant Cell · doi:10.1105/tpc.104.024398 · Cited by 294 · see citing works
Churchman, M. L., Brown, M. L., Kato, N., Kirik, V., Hülskamp, M., Inzé, D., Veylder, L. D., Walker, J. D., Zheng, Z., Oppenheimer, D. G., et al. (2006) · The Plant Cell · doi:10.1105/tpc.106.044834 · Cited by 285 · see citing works
CDK-related protein kinases in plants
Joubès, J., Chevalier, C., Dudits, D., Heberle‐Bors, E., Inzé, D., Umeda, M., & Renaudin, J. (2000) · Plant Molecular Biology · doi:10.1023/a:1006470301554 · Cited by 264 · see citing works
The D-Type Cyclin CYCD3;1 Is Limiting for the G1-to-S-Phase Transition inArabidopsis
Menges, M., Samland, A. K., Planchais, S., & Murray, J. A. H. (2006) · The Plant Cell · doi:10.1105/tpc.105.039636 · Cited by 230 · see citing works
The WD40 Propeller Domain of Cdh1 Functions as a Destruction Box Receptor for APC/C Substrates
Kraft, C., Vodermaier, H. C., Maurer‐Stroh, S., Eisenhaber, F., & Peters, J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.04.023 · Cited by 221 · see citing works
Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis
Veylder, L. D. (2001) · The Plant Cell · doi:10.1105/tpc.13.7.1653 · Cited by 216 · see citing works
The von Hippel–Lindau tumor suppressor protein
Ivan, M., & Kaelin, W. G. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00152-0 · Cited by 211 · see citing works
Genschik, P., Criqui, M., Parmentier, Y., et al. (1998) · The Plant Cell · doi:10.1105/tpc.10.12.2063 · Cited by 211 · see citing works
Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC
Schwab, M. G., Neutzner, M., Möcker, D., & Seufert, W. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5165 · Cited by 209 · see citing works
TPR Subunits of the Anaphase-Promoting Complex Mediate Binding to the Activator Protein CDH1
Vodermaier, H. C., Gieffers, C., Maurer‐Stroh, S., Eisenhaber, F., & Peters, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00581-5 · Cited by 208 · see citing works
A plant cyclin-dependent kinase inhibitor gene
Wang, H., Fowke, L. C., & Crosby, W. L. (1997) · Nature · doi:10.1038/386451a0 · Cited by 200 · see citing works
Magyar, Z., Mészáros, T., Miskolczi, P., Deák, M., Fehér, A., Brown, S., Kondorosi, É., Athanasiadis, A., Pongor, S., Bilgin, M., et al. (1997) · The Plant Cell · doi:10.1105/tpc.9.2.223 · Cited by 198 · see citing works
Boudolf, V., Barrôco, R. D. P., Engler, J. D. A., Verkest, A., Beeckman, T., Naudts, M., Inzé, D., & Veylder, L. D. (2004) · The Plant Cell · doi:10.1105/tpc.021774 · Cited by 193 · see citing works
Tang, Z., Li, B., Bharadwaj, R., Zhu, H., Özkan, E., Hakala, K. W., Deisenhofer, J., & Yu, H. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.12.3839 · Cited by 190 · see citing works
Genome-wide expression analysis of plant cell cycle modulated genes
Breyne, P. (2001) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)00149-7 · Cited by 182 · see citing works
A Plant-specific Cyclin-dependent Kinase Is Involved in the Control of G2/M Progression in Plants
Porceddu, A., Stals, H., Reichheld, J., Segers, G., Veylder, L. D., Barrôco, R. D. P., Casteels, P., MONTAGU, M. V., Inzé, D., & Mironov, V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011060200 · Cited by 173 · see citing works
Cell Type-Specific Role of the Retinoblastoma/E2F Pathway during Arabidopsis Leaf Development
Desvoyes, B., Ramírez-Parra, E., Xie, Q., Chua, N., & Gutiérrez, C. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.071027 · Cited by 164 · see citing works
Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.
Rickert, P., Seghezzi, W., Shanahan, F., Cho, H. K., & Lees, E. M. (1996) · PubMed · Cited by 160 · see citing works
Identification of two cell-cycle-controlling cdc2 gene homologs in Arabidopsis thaliana
Hirayama, T., Yoshiro, I., Anai, T., et al. (1991) · Gene · doi:10.1016/0378-1119(91)90146-3 · Cited by 151 · see citing works
Segers, G., Gadisseur, I., Bergounioux, C., et al. (1996) · The Plant Journal · doi:10.1046/j.1365-313x.1996.10040601.x · Cited by 139 · see citing works
Novák, B., Csikász‐Nagy, A., Györffy, B., Chen, K., & Tyson, J. J. (1998) · Biophysical Chemistry · doi:10.1016/s0301-4622(98)00133-1 · Cited by 135 · see citing works
Wang, W., & Chen, X. (2004) · Development · doi:10.1242/dev.01187 · Cited by 127 · see citing works
The APC Subunit Doc1 Promotes Recognition of the Substrate Destruction Box
Carroll, C. W., Enquist-Newman, M., & Morgan, D. O. (2005) · Current Biology · doi:10.1016/j.cub.2004.12.066 · Cited by 124 · see citing works
The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts.
Hahn, S., Pinkham, J. L., Wei, R., et al. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.2.655 · Cited by 121 · see citing works
There's the Rub: a novel ubiquitin-like modification linked to cell cycle regulationPreprint
Hochstrasser, M. (1998) · Genes & Development · doi:10.1101/gad.12.7.901 · Cited by 120 · see citing works
Lui, H., Wang, H., DeLong, C. M. O., et al. (2000) · The Plant Journal · doi:10.1046/j.1365-313x.2000.00688.x · Cited by 116 · see citing works
Control of Cell Division and Transcription by Cyclin-dependent Kinase-activating Kinases in Plants
Umeda, M., Shimotohno, A., & Yamaguchi, M. (2005) · Plant and Cell Physiology · doi:10.1093/pcp/pci170 · Cited by 115 · see citing works
Cyclin-Dependent Kinase Inhibitors in Maize Endosperm and Their Potential Role in Endoreduplication
Coelho, C. M., Dante, R. A., Sabelli, P. A., Sun, Y., Dilkes, B. P., Gordon-Kamm, W. J., & Larkins, B. A. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.063917 · Cited by 110 · see citing works
Conserved structural motifs in cyclins identified by sequence analysis
Nugent, J. H. A., Alfa, C. E., Young, T., et al. (1991) · Journal of Cell Science · doi:10.1242/jcs.99.3.669 · Cited by 109 · see citing works
Dißmeyer, N., Nowack, M. K., Pusch, S., et al. (2007) · The Plant Cell · doi:10.1105/tpc.107.050401 · Cited by 105 · see citing works
Boruc, J., Mylle, E., Duda, M., Clercq, R. D., Rombauts, S., Geelen, D., Hilson, P., Inzé, D., Damme, D. V., & Russinova, E. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.148643 · Cited by 103 · see citing works
Cell cycle function of a rice B2‐type cyclin interacting with a B‐type cyclin‐dependent kinase
Lee, J., Das, A., Yamaguchi, M., et al. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01736.x · Cited by 103 · see citing works
Zhou, Y., Fowke, L. C., & Wang, H. (2002) · Plant Cell Reports · doi:10.1007/s00299-001-0434-8 · Cited by 101 · see citing works
Mészáros, T., Miskolczi, P., Ayaydin, F., et al. (2000) · Plant Molecular Biology · doi:10.1023/a:1006412413671 · Cited by 93 · see citing works
The developmental context of cell-cycle control in plants
de Jager, S. M., Maughan, S. C., Dewitte, W., Scofield, S., & Murray, J. A. H. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.02.004 · Cited by 90 · see citing works
Bisbis, B., Delmas, F., Joubès, J., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506587200 · Cited by 86 · see citing works
Stals, H., Bauwens, S., Traas, J. A., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01368-9 · Cited by 70 · see citing works
Fülöp, K., Pettkó‐Szandtner, A., Magyar, Z., et al. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02421.x · Cited by 68 · see citing works
Hirt, H., Páy, A., Bögre, L., et al. (1993) · The Plant Journal · doi:10.1046/j.1365-313x.1993.04010061.x · Cited by 67 · see citing works
Zhou, Y., Li, G., Brandizzí, F., Fowke, L. C., & Wang, H. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01821.x · Cited by 62 · see citing works
Orménèse, S. (2004) · Annals of Botany · doi:10.1093/aob/mch077 · Cited by 60 · see citing works
Wyrzykowska, J., Schorderet, M., Pien, S., Gruissem, W., & Fleming, A. J. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.083022 · Cited by 60 · see citing works
Criqui, M., Weingartner, M., Capron, A., et al. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.01180.x · Cited by 58 · see citing works
Activation of an alfalfa cyclin‐dependent kinase inhibitor by calmodulin‐like domain protein kinase
Pettkó‐Szandtner, A., Mészáros, T., Horváth, G. V., Bakó, L., Csordás‐Tóth, É., Blastyák, A., Zhiponova, M., Miskolczi, P., & Dudits, D. (2006) · The Plant Journal · doi:10.1111/j.1365-313x.2006.02677.x · Cited by 58 · see citing works
The cdc2Ms Kinase Is Differently Regulated in the Cytoplasm and in the Nucleus
Bögre, L., Zwerger, K., Meskiene, I., et al. (1997) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.3.841 · Cited by 55 · see citing works
Jasinski, S., Perennes, C., Catherine Bergounioux, A., & Glab, N. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.008573 · Cited by 55 · see citing works
The mitotic spindle checkpoint
Gorbsky, G. J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00609-1 · Cited by 54 · see citing works
Uemukai, K., Iwakawa, H., Kosugi, S., de Uemukai, S., Kato, K., Kondorosi, É., Murray, J. A. H., Ito, M. A., Shinmyō, A., & Sekine, M. (2005) · Plant Molecular Biology · doi:10.1007/s11103-004-6601-x · Cited by 49 · see citing works
Erratum: A human RNA polymerase II complex associated with SRB and DNA-repair proteins
Maldonado, E., Shiekhattar, R., Sheldon, M., Cho, H. K., Drapkin, R., Rickert, P., Lees, E. E., Anderson, C. W., Linn, S., & Reinberg, D. (1996) · Nature · doi:10.1038/384384a0 · Cited by 49 · see citing works
CDK-related protein kinases in plants
Joubès, J., Chevalier, C., Dudits, D., et al. (2000) · Springer eBooks · doi:10.1007/978-94-010-0936-2_6 · Cited by 39 · see citing works
The Electronic Plant Gene Register
(1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.120.1.339 · Cited by 35 · see citing works
Hendil, K. B., & Hartmann‐Petersen, R. (2004) · Current Protein and Peptide Science · doi:10.2174/1389203043379747 · Cited by 34 · see citing works
Jasinski, S., Leite, C. S., Domenichini, S., et al. (2003) · Plant Physiology and Biochemistry · doi:10.1016/s0981-9428(03)00082-2 · Cited by 29 · see citing works
Genschik, P., Criqui, M., Parmentier, Y., et al. (1998) · The Plant Cell · doi:10.2307/3870784 · Cited by 29 · see citing works
Zhiponova, M., Pettkó‐Szandtner, A., Stelkovics, É., Neer, Z., Bottka, S., Krenács, T., Dudits, D., Fehér, A., & Szilák, L. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.072173 · Cited by 27 · see citing works
Mews, M., Sek, F. J., Volkmann, D., et al. (2000) · PROTOPLASMA · doi:10.1007/bf01282924 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Magwanga, R. O., Lu, P., Kirungu, J. N., Cai, X., Zhou, Z., Wang, X., Diouf, L., Xu, Y., Hou, Y., Hu, Y., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092625 · Cited by 88 · see citing works
Tamirisa, S., Vudem, D. R., & Khareedu, V. R. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00165 · Cited by 40 · see citing works
- Authors
- Tank, J. G., & Thaker, V. S.
- Affiliations
- Saurashtra University (IN)
- Venue
- Biologia plantarum
- Publisher
- Institute of Experimental Botany
- Published
- 2011-06-01
- Volume
- 55
- Issue
- 2
- Pages
- 201-212
- ISSN
- 0006-3134 (ISSN-L)
- 1573-8264
- OpenAlex
- W1983074504
- Cited by
- 76
- References
- 80
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 5 · 2023: 11 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 11 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biologia Plantarum (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- cyclin-dependent kinases, cyclin-dependent kinase inhibitors, SCF ubiquitin ligase, anaphase-promoting complex, cyclin degradation, cell division, G1/S transition, G2/M transition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
