The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Death Don't Have No Mercy and Neither Does Calcium: Arabidopsis CYCLIC NUCLEOTIDE GATED CHANNEL2 and Innate Immunity
Open accessAbstract
Plant innate immune response to pathogen infection includes an elegant signaling pathway leading to reactive oxygen species generation and resulting hypersensitive response (HR); localized programmed cell death in tissue surrounding the initial infection site limits pathogen spread. A veritable symphony of cytosolic signaling molecules (including Ca2+, nitric oxide [NO], cyclic nucleotides, and calmodulin) have been suggested as early components of HR signaling. However, specific interactions among these cytosolic secondary messengers and their roles in the signal cascade are still unclear. Here, we report some aspects of how plants translate perception of a pathogen into a signal cascade leading to an innate immune response. We show that Arabidopsis thaliana CYCLIC NUCLEOTIDE GATED CHANNEL2 (CNGC2/DND1) conducts Ca2+ into cells and provide a model linking this Ca2+ current to downstream NO production. NO is a critical signaling molecule invoking plant innate immune response to pathogens. Plants without functional CNGC2 lack this cell membrane Ca2+ current and do not display HR; providing the mutant with NO complements this phenotype. The bacterial pathogen–associated molecular pattern elicitor lipopolysaccharide activates a CNGC Ca2+ current, which may be linked to NO generation due to buildup of cytosolic Ca2+/calmodulin.
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Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,821
WHITE, P. J. (2003) · Annals of Botany · doi:10.1093/aob/mcg164 · Cited by 2,381
Nitric oxide functions as a signal in plant disease resistance
Delledonne, M., Xia, Y., Dixon, R. A., & Lamb, C. (1998) · Nature · doi:10.1038/29087 · Cited by 1,857
Reactive Oxygen Species Signaling in Response to Pathogens
Torres, M. A., Jones, J. D. G., & Dangl, J. L. (2006) · Plant Physiology · doi:10.1104/pp.106.079467 · Cited by 1,735
Defense gene induction in tobacco by nitric oxide, cyclic GMP, and cyclic ADP-ribose
Durner, J., Wendehenne, D., & Klessig, D. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10328 · Cited by 1,331
Innate immunity in plants and animals: striking similarities and obvious differences
Nürnberger, T., Brunner, F., Kemmerling, B., & Piater, L. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0119.x · Cited by 1,286
Hydrogen peroxide and nitric oxide as signalling molecules in plants
Neill, S. J. (2002) · Journal of Experimental Botany · doi:10.1093/jexbot/53.372.1237 · Cited by 1,225
Delledonne, M., Zeier, J., Marocco, A., & Lamb, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231178298 · Cited by 1,081
ABA‐induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis
Bright, J., Desikan, R., Hancock, J. T., Weir, I. S., & Neill, S. J. (2006) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02615.x · Cited by 1,001
Identification of a Plant Nitric Oxide Synthase Gene Involved in Hormonal Signaling
Guo, F.-Q., Okamoto, M., & Crawford, N. M. (2003) · Science · doi:10.1126/science.1086770 · Cited by 889
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The Language of Calcium Signaling
Dodd, A. N., Kudla, J., & Sanders, D. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-070109-104628 · Cited by 1,317
Calcium Signals: The Lead Currency of Plant Information Processing
Kudla, J., Batistič, O., & Hashimoto, K. (2010) · The Plant Cell · doi:10.1105/tpc.109.072686 · Cited by 1,075
New Insights into Nitric Oxide Signaling in Plants
Besson-Bard, A., Pugin, A., & Wendehenne, D. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092830 · Cited by 801
Coping with Stresses: Roles of Calcium- and Calcium/Calmodulin-Regulated Gene Expression
Reddy, A. S. N., Ali, G. S., Celesnik, H., & Day, I. S. (2011) · The Plant Cell · doi:10.1105/tpc.111.084988 · Cited by 784
Susceptibility Genes 101: How to Be a Good Host
van Schie, C. C. N., & Takken, F. L. W. (2014) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-102313-045854 · Cited by 658
Metadata
- Authors
- Ali, R., Ma, W., Lemtiri-Chlieh, F., Tsaltas, D., Leng, Q., von Bodman, S., & Berkowitz, G. A.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03-01
- Volume
- 19
- Issue
- 3
- Pages
- 1081-1095
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2166498325
- Cited by
- 386
- References
- 56
- FWCI
- 34.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Ali, R., Ma, W., Lemtiri-Chlieh, F., Tsaltas, D., Leng, Q., von Bodman, S., & Berkowitz, G. A. (2007). Death Don't Have No Mercy and Neither Does Calcium: Arabidopsis CYCLIC NUCLEOTIDE GATED CHANNEL2 and Innate Immunity. The Plant Cell. https://doi.org/10.1105/tpc.106.045096
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