The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
NPS6, Encoding a Nonribosomal Peptide Synthetase Involved in Siderophore-Mediated Iron Metabolism, Is a Conserved Virulence Determinant of Plant Pathogenic Ascomycetes
Open accessAbstract
NPS6, encoding a nonribosomal peptide synthetase, is a virulence determinant in the maize (Zea mays) pathogen Cochliobolus heterostrophus and is involved in tolerance to H2O2. Deletion of NPS6 orthologs in the rice (Oryza sativa) pathogen, Cochliobolus miyabeanus, the wheat (Triticum aestivum) pathogen, Fusarium graminearum, and the Arabidopsis thaliana pathogen, Alternaria brassicicola, resulted in reduced virulence and hypersensitivity to H2O2. Introduction of the NPS6 ortholog from the saprobe Neurospora crassa to the Δnps6 strain of C. heterostrophus restored wild-type virulence to maize and tolerance to H2O2, demonstrating functional conservation in filamentous ascomycete phytopathogens and saprobes. Increased sensitivity to iron depletion was identified as a conserved phenotype of Δnps6 strains. Exogenous application of iron enhanced the virulence of Δnps6 strains of C. heterostrophus, C. miyabeanus, F. graminearum, and A. brassicicola to each host. NPS6 is responsible for the biosynthesis of extracellular siderophores by C. heterostrophus, F. graminearum, and A. brassicicola. Application of the extracellular siderophore of A. brassicicola restored wild-type virulence of the ΔAbnps6 strain to Arabidopsis. It is proposed that the role of extracellular siderophores in fungal virulence to plants is to supply an essential nutrient, iron, to their producers in planta and not to act as phytotoxins, depriving their hosts of iron.
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Schrettl, M., Bignell, E., Kragl, C., Joechl, C., Rogers, T., Arst, H. N., Haynes, K., & Haas, H. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041242 · Cited by 493
Self-citationBearden, S. W., & Perry, R. D. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01360.x · Cited by 254
Cited by
Distinct Roles for Intra- and Extracellular Siderophores during Aspergillus fumigatus Infection
Schrettl, M., Bignell, E., Kragl, C., Sabiha, Y., Loss, O., Eisendle, M., Wallner, A., Arst, H. N., Haynes, K., & Haas, H. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030128 · Cited by 405
Self-citationFungal siderophore metabolism with a focus on Aspergillus fumigatus
Haas, H. (2014) · Nat. Prod. Rep. · doi:10.1039/c4np00071d · Cited by 324
Self-citationHapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus
Schrettl, M., Beckmann, N., Varga, J., Heinekamp, T., Jacobsen, I. D., Jöchl, C., Moussa, T. A., Wang, S., Gsaller, F., Blatzer, M., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001124 · Cited by 284
Self-citationVerbon, E. H., Trapet, P. L., Stringlis, I. A., Kruijs, S., Bakker, P. A. H. M., & Pieterse, C. M. J. (2017) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080516-035537 · Cited by 241
Interaction of HapX with the CCAAT‐binding complex—a novel mechanism of gene regulation by iron
Hortschansky, P., Eisendle, M., Al‐Abdallah, Q., Schmidt, A. D., Bergmann, S., Thön, M., Kniemeyer, O., Abt, B., Seeber, B., Werner, E. R., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601752 · Cited by 232
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Metadata
- Authors
- Oide, S., Moeder, W., Krasnoff, S., Gibson, D., Haas, H., Yoshioka, K., & Turgeon, B. G.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-01
- Volume
- 18
- Issue
- 10
- Pages
- 2836-2853
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2126134985
- Cited by
- 351
- References
- 2
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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