The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nucleocytoplasmic Shuttling of BZR1 Mediated by Phosphorylation Is Essential in Arabidopsis Brassinosteroid Signaling
Open accessAbstract
Phytohormone brassinosteroids (BRs) play critical roles in plant growth and development. BR acts by modulating the phosphorylation status of two key transcriptional factors, BRI1 EMS SUPPRESSOR1 and BRASSINAZOLE RESISTANT1 (BZR1), through the action of BRASSINOSTEROID INSENSITIVE1/BRI1 ASSOCIATED RECEPTOR KINASE1 receptors and a GSK3 kinase, BRASSINOSTEROID INSENSITIVE2 (BIN2). It is still unknown how the perception of BR at the plasma membrane connects to the expression of BR target genes in the nucleus. We show here that BZR1 functions as a nucleocytoplasmic shuttling protein and GSK3-like kinases induce the nuclear export of BZR1 by modulating BZR1 interaction with the 14-3-3 proteins. BR-activated phosphatase mediates rapid nuclear localization of BZR1. Besides the phosphorylation domain for 14-3-3 binding, another phosphorylation domain in BZR1 is required for the BIN2-induced nuclear export of BZR1. Mutations of putative phosphorylation sites in two distinct domains enhance the nuclear retention of BZR1 and BR responses in transgenic plants. We propose that the spatial redistribution of BZR1 is critical for proper BR signaling in plant growth and development.
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Citations
Cites
BRI1/BAK1, a Receptor Kinase Pair Mediating Brassinosteroid Signaling
Nam, K. H., & Li, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00814-0 · Cited by 1,217
Cited by
Kim, T.-W., Guan, S., Sun, Y., Deng, Z., Tang, W., Shang, J.-X., Sun, Y., Burlingame, A. L., & Wang, Z.-Y. (2009) · Nature Cell Biology · doi:10.1038/ncb1970 · Cited by 693
Yu, X., Li, L., Zola, J., Aluru, M., Ye, H., Foudree, A., Guo, H., Anderson, S., Aluru, S., Liu, P., et al. (2011) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04449.x · Cited by 666
PP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1
Tang, W., Yuan, M., Wang, R., Yang, Y., Wang, C., Oses-Prieto, J. A., Kim, T.-W., Zhou, H.-W., Deng, Z., Gampala, S. S., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2151 · Cited by 494
Choi, J., Huh, S. U., Kojima, M., Sakakibara, H., Paek, K.-H., & Hwang, I. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.011 · Cited by 473
Self-citationBreakspear, A., Liu, C., Roy, S., Stacey, N., Rogers, C., Trick, M., Morieri, G., Mysore, K. S., Wen, J., Oldroyd, G. E. D., et al. (2014) · The Plant Cell · doi:10.1105/tpc.114.133496 · Cited by 377
Metadata
- Authors
- Ryu, H., Kim, K., Cho, H., Park, J., Choe, S., & Hwang, I.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09-01
- Volume
- 19
- Issue
- 9
- Pages
- 2749-2762
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2156541025
- Cited by
- 335
- References
- 1
- FWCI
- 18.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ryu, H., Kim, K., Cho, H., Park, J., Choe, S., & Hwang, I. (2007). Nucleocytoplasmic Shuttling of BZR1 Mediated by Phosphorylation Is Essential in Arabidopsis Brassinosteroid Signaling. The Plant Cell. https://doi.org/10.1105/tpc.107.053728
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