The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Autophagy Negatively Regulates Cell Death by Controlling NPR1-Dependent Salicylic Acid Signaling during Senescence and the Innate Immune Response in Arabidopsis
Open accessAbstract
Autophagy is an evolutionarily conserved intracellular process for vacuolar degradation of cytoplasmic components. In higher plants, autophagy defects result in early senescence and excessive immunity-related programmed cell death (PCD) irrespective of nutrient conditions; however, the mechanisms by which cells die in the absence of autophagy have been unclear. Here, we demonstrate a conserved requirement for salicylic acid (SA) signaling for these phenomena in autophagy-defective mutants (atg mutants). The atg mutant phenotypes of accelerated PCD in senescence and immunity are SA signaling dependent but do not require intact jasmonic acid or ethylene signaling pathways. Application of an SA agonist induces the senescence/cell death phenotype in SA-deficient atg mutants but not in atg npr1 plants, suggesting that the cell death phenotypes in the atg mutants are dependent on the SA signal transducer NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1. We also show that autophagy is induced by the SA agonist. These findings imply that plant autophagy operates a novel negative feedback loop modulating SA signaling to negatively regulate senescence and immunity-related PCD.
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Cites
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
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The role of autophagy during the early neonatal starvation period
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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
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“In mammalian cells, autophagy also can be induced by H2O2 via ATG4 protein activity ( Scherz-Shouval et al., 2007 ).”
BackgroundAutophagy: from phenomenology to molecular understanding in less than a decade
Klionsky, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2245 · Cited by 1,934
Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae
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Self-citationA Central Role of Salicylic Acid in Plant Disease Resistance
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Autophagy in cell death: an innocent convict?
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COI1 : An Arabidopsis Gene Required for Jasmonate-Regulated Defense and Fertility
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Cited by
Salicylic acid beyond defence: its role in plant growth and development
Rivas-San Vicente, M., & Plasencia, J. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err031 · Cited by 1,444
Autophagy: Pathways for Self-Eating in Plant Cells
Liu, Y., & Bassham, D. C. (2012) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105441 · Cited by 600
Morphological classification of plant cell deaths
van Doorn, W. G., Beers, E. P., Dangl, J. L., Franklin-Tong, V. E., Gallois, P., Hara-Nishimura, I., Jones, A. M., Kawai-Yamada, M., Lam, E., Mundy, J., et al. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.36 · Cited by 584
Jiang, Y., Liang, G., Yang, S., & Yu, D. (2014) · The Plant Cell · doi:10.1105/tpc.113.117838 · Cited by 484
WRKY54 and WRKY70 co-operate as negative regulators of leaf senescence in Arabidopsis thaliana
Besseau, S., Li, J., & Palva, E. T. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/err450 · Cited by 472
Metadata
- Authors
- Yoshimoto, K., Jikumaru, Y., Kamiya, Y., Kusano, M., Consonni, C., Panstruga, R., Ohsumi, Y., & Shirasu, K.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-09-01
- Volume
- 21
- Issue
- 9
- Pages
- 2914-2927
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2130307437
- Cited by
- 571
- References
- 63
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Autophagy Negatively Regulates Cell Death by Controlling NPR1-Dependent Salicylic Acid Signaling during Senescence and the Innate Immune Response in Arabidopsis. https://app.cochat.ai/papers/10.1105/tpc.109.068635
- The paper
- Yoshimoto, K., Jikumaru, Y., Kamiya, Y., Kusano, M., Consonni, C., Panstruga, R., Ohsumi, Y., & Shirasu, K. (2009). Autophagy Negatively Regulates Cell Death by Controlling NPR1-Dependent Salicylic Acid Signaling during Senescence and the Innate Immune Response in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.109.068635
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